<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02373

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMEPGDYFTNVLSSNNYGSIQYEYFESQTSSSAGIWKHLQRVEAKWRKEGILVHCDPFKDGIWIYQNAAGSAPSSQEPIATTSTIVDTSTMDLVLRDKGTYEPASLSKNKLLSATSISASSVNSSPSSLENSIRNVQSINSRAIQVNSNYNVVNEPPTPPPGTRSIASAGESYPYLKHIHDCFISAVLGSVVYFLCRDYGYIPLNSRTLLLASPKFSPRQCHKHNQMEGGNTITLATLDISLTTLGALVVKASSDTAPGLLSVASSPVPPSGSYPNISPGTALWLAPGGNAAKFFGTQQEKKLSANLLISHLQANTVDHRQHGFNGATIQSWQTKCLEWLAEKGLNTTELEEGGWVLVQVLSGSSPYFNSDFQGNPMLEALTIVPWPALLCFQTTNTSNREFHPIAAKNSQLDPLSFAEEWFTNKDERANVITRRQKERQLAEARAKEQADVDARNLQSITQSPAALRRGSVSGAVYPTPPDAVHNPLGATPSLDGGVSTPGNPNQLFTNELDTTSTNAIPGTAGQDSDVWDSSDKIERGATNMNFHGNDNDNDVLFRDATADLFGDVTDADFSFFDEPDMIQVDPQTTSPGNMALGIQETRQEQEISALDSEDASFSNAPRAILDANDDVSSAQHEKPESPMKINVPNGPAEHEISENTLETSEAAINPPIQEPFNKEAVFQRLFQGERLQKQSSTPRRLSAFNAVDFESSLISVNKKYGSTGRFRFSEKGKRLQHVASPSIPKTDYLSRRRKLTHNENEWINLAKLLHQEESGILDHPPEDDQSMLYLVDIDHTSVTSEQDDTSHTTDDLSLALKPGIKRKWAMDEDRDDMTSSFDALLMDYPQSASTPLSISGSQIPLLEGDPADWSLTTYFNSPEPDIQSTALTDLEYIATAQILGDQAVSGTVKIPGSSSLGNDLQLSDLRVAATRTLMHSLATSTNACLGDISNCTLRSFLEIQGIPVLNHGLRLPPRPNTNHKGAVVDHLRASNPFPITSPQLEVRRADSKLSVLPSAVSFWENLSLSPSCGSKDVNAVCVFPNFDGVAGNAAIFLDQMRSVYESSRLGGHDKVSCKDVSDGLVPYNTDAGQQTSKMHHLTALKEATARLGRALASLSVEEKNFVVYFVYPVDNSALLVHICSAFQHLFNMYRKALSDRKISVANELVLQLVPLDFVASHTCLVVPSPTEYARLAMEVFDRCIDFTSASSNPGILLEQPLPKNIDFKLNVNPSASLLQENSCLHIAYAQSIDDRWITAAWTDNRGTQQMTASYCLGRKNEQISMAFPAVAHEIWETTLEIISGKKIHWRIMIARVGVMDPSEVEFWAGLASTESNVPVNLTLVTVQTDPSLRLLPAPSTLSPVSNAPQAVVTPVSTPQTAPAAVLSPEAVGTPSREPASAATPIDGNAEPDSDARLLDYTDQSWGAVLSHRLNNSNSLLELNPALISGYLIKNGGTNSDDQPVVMEVNIVYSEIAGNPRTFHENLLREILGYYRNLGTLARVRGVVDSVKDIRPWHIAAAEKAVKALYMLM
Length1527
PositionKinase
OrganismOidiodendron maius Zn
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Leotiomycetes incertae sedis> Myxotrichaceae> Oidiodendron.
Aromaticity0.07
Grand average of hydropathy-0.320
Instability index44.68
Isoelectric point5.11
Molecular weight166577.38
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02373
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     107.00|      33|      41|    1031|    1071|       1
---------------------------------------------------------------------------
 1031- 1065 (53.74/52.89)	DVNAVCVFPNFDgvAGNAAIFLDQMRSVYE.SSRLG
 1074- 1107 (53.26/30.63)	DVSDGLVPYNTD..AGQQTSKMHHLTALKEaTARLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.63|      21|      25|     525|     549|       2
---------------------------------------------------------------------------
  509-  529 (33.75/12.59)	NELDTTSTNAIPGTAGQDSDV
  534-  554 (35.88/23.67)	DKIERGATNMNFHGNDNDNDV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     124.54|      38|      46|     569|     607|       3
---------------------------------------------------------------------------
  569-  607 (62.83/41.44)	DADFSFFDEPDMIQvDPQTTSP.GNMALGIQETRQEQEIS
  618-  656 (61.71/36.41)	NAPRAILDANDDVS.SAQHEKPeSPMKINVPNGPAEHEIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.63|      30|      47|     892|     921|       5
---------------------------------------------------------------------------
  892-  921 (49.43/29.35)	IATA..QILGDQA...VSGTVKIPGSSSLGNDLQL
  936-  970 (41.20/23.27)	LATStnACLGDISnctLRSFLEIQGIPVLNHGLRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.99|      14|      19|    1363|    1378|       6
---------------------------------------------------------------------------
 1363- 1376 (25.96/15.94)	PQAVVTPVSTPQTA
 1383- 1396 (26.03/ 9.07)	PEAVGTPSREPASA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      78.20|      19|      19|    1190|    1208|       7
---------------------------------------------------------------------------
 1190- 1208 (33.84/24.88)	LAME.VFDRCIDFTSASSNP
 1210- 1228 (25.03/16.15)	ILLEqPLPKNIDF.KLNVNP
 1232- 1246 (19.33/10.50)	LLQE...NSCLHIAYAQS..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.12|      25|      46|     323|     348|       8
---------------------------------------------------------------------------
  323-  348 (41.63/27.90)	FNGATIQSWQTkCLEWLAEKGLNTTE
  371-  395 (46.48/27.06)	FQGNPMLEALT.IVPWPALLCFQTTN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.58|      29|     571|     837|     866|       9
---------------------------------------------------------------------------
  837-  866 (49.23/28.97)	DALLMDY.PQSASTPLS..ISGSQiPLLEGDPA
 1409- 1440 (43.35/21.21)	DARLLDYtDQSWGAVLShrLNNSN.SLLELNPA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     360.24|      88|      98|      85|     173|      10
---------------------------------------------------------------------------
    2-   72 (98.59/59.74)	................EPGDYFTNVLSSNNygSIQYEYFESQTSSSAGIWKHLQRVEAK...WRK.EGILVHCDPF.KDGIWIYQNA....AGSAP
   85-  173 (137.93/91.59)	VDTSTMDLVLRDKGtYEPASLSKNKLLSAT..SISASSVNSSPSSLENSIRNVQSINSRAIQVNS.NYNVVNEPPTPPPGTRSIASA....GESYP
  186-  274 (123.73/77.49)	VLGSVVYFLCRDYG.YIPLN.SRTLLLASP..KFSPRQCHKH.NQMEGG..NTITLATLDISLTTlGALVVKASSDTAPGLLSVASSpvppSGSYP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.70|      15|     301|    1007|    1026|      11
---------------------------------------------------------------------------
 1012- 1026 (28.62/23.31)	PSAVSFWENLSLSPS
 1316- 1330 (28.08/10.98)	PSEVEFWAGLASTES
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.99|      22|      25|     782|     803|      15
---------------------------------------------------------------------------
  782-  803 (34.91/23.61)	DDQSMLYLVDIDHT.SVTSEQDD
  809-  831 (29.08/18.28)	DDLSLALKPGIKRKwAMDEDRDD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.54|      29|      42|    1108|    1138|      16
---------------------------------------------------------------------------
 1108- 1138 (44.79/36.50)	RALASLSVEEKNFVVYFVYPVDNSAllVHIC
 1150- 1178 (47.75/32.40)	KALSDRKISVANELVLQLVPLDFVA..SHTC
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02373 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) APAAVLSPEAVGTPSREPASAATPIDGNAEPDSDARL
2) FFDEPDMIQVDPQTTSPGNMALGIQETRQEQEISALDSEDASFSNAPRAILDANDDVSSAQHEKPESPMKINVPNGPAEHEISENTLETSEAAINPPIQE
3) ITRRQKERQLAEARAKEQADVDARNLQSITQSPA
4) RRGSVSGAVYPTPPDAVHNPLGATPSLDGGVSTPGNPNQLFTNELDTTSTNAIPGTAGQDSDVWDSSDKIERGATNMNFHGNDNDNDVLFRDAT
1376
574
431
467
1412
673
464
560










Molecular Recognition Features






MoRF SequenceStartStop




1) IKRKWA
819
824