<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02370

Description Uncharacterized protein
SequenceMTSRPNVGQRPPPRSLSANLLQRPAAPPSPSRRNHDTYADVTFDGPDAVLPRYGLPPKMAGSRLKLETSRDSQSADIGETAKSSTLEVPPIWRHPRGRPQLHFDVPSISNPGPRAAQDGDRPDGAINPMPLPIRPGHHPRPTVDRPRGEPANAQKKDSRPKPYTLEVPAAAARYSQNGYADFFPWTGNHPEDKFSENAIRQGFYDKAQLTQNETGSGKSSILPPLKHKSGLQTLSSLFTNVLAQRRAHGQITSNSTFKPPPRVTVTDTKREMWLKDLANPTISLRRLSRSIPHGIRGKVLLDQSLSKNIPIERAVWLAKCVGANELRSFRRKGASGLPMVGEAKWIREFTVCVEQFVESIVETCGDKDFRGRVNYALRLAAQFHSEHLLDRDHYLDWLVSALENCPQAKLPIWLLITQIYWKDILKSRKFGRRLSAALLSQWAQTLVHPDVDILAPLSDRLKMLLKQLMTFNPESFISSKAWAAHRAAITSTLAAEDARFAAILSSIDRRNGRFILSDAEKNPSPRTRLILLLDTTFSKPFTGDLLENCWRIDDDKDMLLRTILEWSTSSYRPGTAKIYVAARLFRHSAMSGTDITQAILSFLDSDVCEIGRSKSALYHLVSELSRSEHFSIPMYLQWLIARGGLYNAAEVSWDGPCATRLLVELPTYSLTESMDALRRTLLSRAGYSTDDEDELARAYMARLSKRLPGMQASMDSELETEMDIANDGHDSAFTLSRGNMSEVVRHTLEDIQDFSILADVLKIVSSSNDAEVLASCTDTVNLHLDSFAAIGAVKGLFEILTSRLQSLAEDDSFPRVLLVSLSQLAARIPGQDDVARKLVQELSRSDRKTAADACSPVSDHMVGVTQTTEADFNDEIEKVLASGNSMDQATLERLFQRIMNRLEETWEKPSDQYRSCGLLLTRLRAFDPQPFDVLMTAWVARFFQMEHRPSMARVLGPLISFGCVSLQDVTMKSISMVEADTLLENHTQSRLSEEALALLVDSSDNLDTMTSEEVYRLRIYQTNMQRDRPLDILSVIRRSLTAESNDTMAKFGAPQSEKSNPALHEFLERLVLLDTESVIQMLILPLLTSSNTKISSTISVFVDRLLMGDGDKDVESIPIDLVLNLADDFTLPFCQVKLASIFIPGQSIPRTAESAEDADMEDSRLLQAFDIAIDSAVAARNTAWTCIIPLLDISIARHLRQRAESQFVAIFPSAKGSSATELHTLQGGIEQATNLLYIIDATVYSISNTASTPSLAPEIVSMLNSTWYLLSSSQASFQDVKEVVITKWLPLLLSFATVHISSFGQTKAGHEHRSKALLALAAIILELQARDDSMEGMNAIIEETFDLALHLIDALPGDMRQQCTTSLREVSNRRISYLFSITKDPSDWLVLSQKERINVSGTAERRATVLEKEKLAPYPLRRWEMLGEPTPNIGENDTSLSLTLFGARKFFLR
Length1453
PositionKinase
OrganismOidiodendron maius Zn
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Leotiomycetes incertae sedis> Myxotrichaceae> Oidiodendron.
Aromaticity0.07
Grand average of hydropathy-0.255
Instability index45.64
Isoelectric point6.08
Molecular weight162022.65
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02370
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     155.61|      52|     286|     477|     532|       1
---------------------------------------------------------------------------
  477-  532 (78.66/61.05)	ISSKAWAAHRAAITSTLAAEDARFAAIlSSIdrrNGRF.ILSD.....AEKNPSPRTRLILL
  764-  821 (76.95/47.65)	VSSSNDAEVLASCTDTVNLHLDSFAAI.GAV...KGLFeILTSrlqslAEDDSFPRVLLVSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.46|      26|     116|     537|     584|       2
---------------------------------------------------------------------------
  557-  584 (38.26/65.09)	DMLLRTILE...WSTSSyRPGTAKIYVaARL
  675-  703 (40.19/14.06)	DALRRTLLSragYSTDD.EDELARAYM.ARL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     139.23|      37|     239|     348|     404|       3
---------------------------------------------------------------------------
  348-  384 (66.08/29.38)	EFTVCVEQFVESIVETCGDKDFRG.RVNYALRLAAQFH
  594-  619 (42.91/13.81)	DITQAILSFLDS..DVC...EI.G.RSKSAL.....YH
 1101- 1129 (30.23/ 7.97)	........FVDRLLMGDGDKDVESiPIDLVLNLADDF.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.55|      19|     239|     385|     404|       4
---------------------------------------------------------------------------
  385-  404 (32.17/23.92)	SEHlLDRDHYLDWLVS..ALEN
  627-  647 (32.39/19.24)	SEH.FSIPMYLQWLIArgGLYN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     243.26|      50|     118|       4|      53|       5
---------------------------------------------------------------------------
    4-   51 (82.89/47.82)	......RPNVGQRP..P....PRSLSANLLQ...RP.....A.APPSPSRRNHDTYADVTFDGPD.AV....LP
   52-   87 (33.57/14.57)	RY............glP....PK.MAGSRLK...LE.....T.SRDSQSADIGETAKSSTLE............
   89-  132 (33.19/14.32)	.............P..PiwrhPRGRPQLHFD...VP.....SiSNPGP.RAAQDG......DRPDgAInpmpLP
  134-  182 (37.19/17.02)	RPghhpRPTVDR.........PRGEPANAQKkdsRPkpytlE.VPAAAARYSQNGYADF...............
  184-  223 (56.43/29.98)	.......PWTGNHP..E....DK.FSENAIR...QG.....F.YDKAQLTQNE......TGSGKS.SI....LP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     144.15|      46|     118|     706|     753|       6
---------------------------------------------------------------------------
  706-  753 (70.56/55.68)	RLPGmQASMDSELETEMDiANDGHDSAFTLS..RGNMSEVVRHTLEDIQD
  827-  874 (73.59/48.30)	RIPG.QDDVARKLVQELS.RSDRKTAADACSpvSDHMVGVTQTTEADFND
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     226.92|      74|     283|    1021|    1100|       7
---------------------------------------------------------------------------
 1021- 1100 (108.25/80.89)	QT...NMQRDRPLDILSVIRRSLTAEsNDTMAKFGAPQSEKSNPALHeFLERLvlldTESVIQMLILPLLTSSNTKISSTISV
 1305- 1381 (118.67/71.67)	QTkagHEHRSKALLALAAIILELQAR.DDSMEGMNAIIEETFDLALH.LIDAL....PGDMRQQCTTSLREVSNRRISYLFSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.56|      26|     436|     431|     476|       8
---------------------------------------------------------------------------
  273-  303 (36.32/ 6.79)	WLKDLANPTISLrrLSrsiPHGIRGKVLLDQ
  442-  467 (46.24/51.34)	WAQTLVHPDVDI..LA...PLSDRLKMLLKQ
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02370 with Med12 domain of Kingdom Fungi
Unable to open file!