<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02368

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGAIMENGAGSYTNHDRDQRQNGVNGSGYSMEKVQDRGSERVEQQQKMAPPNSVHRAVFTNPPDLQEQINKLPPEIAHITQGYMSLSTLLKRLSARTHEDLKAKVLQLSQMPIPSSALNMNGSQITSVDDNSPENLSKKLALLNFAQSTHADWVKALVITNWSRRSEDVSKTIDLKIYLDRQKSMYESAIHEMSEVKRSLPYARMPNPDLKTALQVLSTGKAPWMPELGYILPPPLMSCDVLNTLENLNTLLSIRLNLHEYDNIPLQFKDYTIKSGRVTFKVAGEFEIDLTIADEDPEKQFWFIDLRFLFSPAVLELPTHLRYYIESRVNAVLLTDGLPGCYKLLHEMVLTHKISEFRRQASELARGKWVESLKIEALNRAVSIQYWLDRYGAKGPKSWIVLGVHSGRRKDGRFDPKSASHLFVRWFRDGKEIKDADIRFDTVSLSAEALLKTVIAKHVAYILKAIHEKLQSKPLFAGNEMALEITTSIDEPSETVLKVQVTSKQTISVSVEPITGRFIVGPGSLHNMRAEYGFNSKSTDPANDGHSYIEQLRCDTAADEITTHGLSVGWSRIRRPDLKADDLKQVLPKDTLQVAWFRRPGWRKEWFIAVSLSMGGDRWWLIETLNQPPELTITSHLEIPIRASAPAPTYNFLSTLGIFAAAVVSHYANLKALHSQHAFYVLKSSKTSSSISLPSIFLKLSELLPSRNRLKRTRKPWAKDIVKVTFQGLESTPPAAVPASPSQLELPASTPAPDAIEAPKKEDQEGTLITVTEARIVVPVPATLSILKERVDQDIAFHAESGTFACRLRSRVGESVIPVLTERAIRIERLVEFVEVLHKHSTTLRCDSISLGKIILLYGTSTGSLVEAGDSIGAVIPQYKAVVDFGAVSSTMTISFEKGNPHLLIADRLARVLNGNEGLNGVAQLLPLTLPALRALDTIEEAWTSLSDKGDVLVFVRAVDWYRFSYSLLPTSIQVSSTTSPRKVVFDLKLQQRKGEPWWFVRRVDHPGKEGDDIDALLKPVWNSSGEGYRGMRVNAVAQPNGIEELLGKLDDVLRAFASGYKPMHTIGQGQASHTPRQVVPVATMAQAQAKSNRPVMSIPKQRQQPTPNQTQSQGMSHSSQMEVVEID
Length1129
PositionTail
OrganismOidiodendron maius Zn
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Leotiomycetes incertae sedis> Myxotrichaceae> Oidiodendron.
Aromaticity0.07
Grand average of hydropathy-0.281
Instability index45.23
Isoelectric point8.77
Molecular weight125903.61
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02368
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.41|      10|      15|    1064|    1073|       1
---------------------------------------------------------------------------
 1064- 1073 (20.38/16.22)	PMHTIGQGQA
 1082- 1091 (18.02/13.36)	PVATMAQAQA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     182.03|      68|     301|     547|     632|       2
---------------------------------------------------------------------------
  547-  630 (86.54/95.64)	HSYIEQLRCDTAAdeITTH..GLSVGWSR..............IRRPDLKAdDLKQVLP.KDTLQVAwfRRPgWRKEwfiAVSLSMGGdrwwlIETlnQPP
  651-  735 (95.49/50.73)	YNFLSTLGIFAAA..VVSHyaNLKALHSQhafyvlkssktsssISLPSIFL.KLSELLPsRNRLKRT..RKP.WAKD...IVKVTFQG.....LES..TPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.35|      15|      17|     397|     413|       3
---------------------------------------------------------------------------
  397-  413 (25.51/20.82)	PKSWIVLGVHSGRrkDG
  417-  431 (30.84/18.41)	PKSASHLFVRWFR..DG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.14|      12|     110|     636|     649|       4
---------------------------------------------------------------------------
  636-  649 (19.90/18.56)	SHLEIPirASAPAP
  743-  754 (24.24/14.79)	SQLELP..ASTPAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     170.56|      59|     110|      87|     146|       6
---------------------------------------------------------------------------
   87-  146 (93.45/64.61)	LSTLLKRLS.AR.THEDLKA..KVLQLSQMP.IPSSALNMnGSQITSVD.DNSPENLSKKLAL.LNF
  194-  259 (77.11/48.15)	MSEVKRSLPyARmPNPDLKTalQVLSTGKAPwMPELGYIL.PPPLMSCDvLNTLENLNTLLSIrLNL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.24|      13|      17|    1009|    1021|       9
---------------------------------------------------------------------------
 1009- 1021 (22.42/15.38)	GKEGDDIDALLKP
 1029- 1041 (23.82/16.82)	GYRGMRVNAVAQP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02368 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MHTIGQGQASHTPRQVVPVATMAQAQAKSNRPVMSIPKQRQQPTPNQTQSQGMSHSSQMEVVEID
2) MPGAIMENGAGSYTNHDRDQRQNGVNGSGYSMEKVQDRGSERVEQQQKMAPPNSVHRAVFTNPPDLQEQINKLPP
1065
1
1129
75










Molecular Recognition Features






MoRF SequenceStartStop




NANANA