<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02366

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMYLADLTRNSFQSGISATKWLALCKLLLSKMPAISLEGSGKVATNLSNSVLVLYRSYPGDPGLQDYLKAAIQDGILPVSTFVATLLQAARSSELHIPATLDTLCRIALDAHYSSGQPPIGSVVPFSEPSNVTLGTVQDGLALLRTAYSLPISHFHQLTASVSELVILLFSCVSDLSQLSTAQAMVYFEDVNYLLTNYRLTADLRQVLDTFLVSLTLLIGDDAKSARDAQLSHTIQFSLNKGDILGPSSDTDIISLGLLLNHLVTKLFSLLPLFLTYLFFPSLSFSLFFFKVTYRAHNFGAGDITNSVALLVSSFRWSSWTPTVYYTQLLLSAFTCLSQSGGNSRLWKAFIVGRLPVLLAKFAEVVTADKATNTDLNGALHAGLTAIFRRPDIIIQGDHALSRDANLDPSLDEDISRSFSREFLQQLVKHNLVVQQLAVQLDPMLFSDSPPKWHVEANDVGLELAAYLEAKLMQESNVGDAKVWIDRIWRDPGSHAIFANLVLKRFTSSVTLMEVDSLGHLCKILHTYEHGLDIVALHERIKDLLFLALQFLEDYDCETVGDPQTAFSHLGDVVLFVQYTFTRFKFENKEITKNGRTVSPGYIVDTDVVVHPLARSPEDMASLNAWFKALFDSNSEGIEDNILRSTKLRILLRIAPPLITNAIQMTAVHKMERDVLTNGVSYFTGPLLNWTLVNVIKSLIKEIQSRQFAAPSHYDTVQTLILSPSCPRSVLALCSPKFMILLADKKRQPNSFNVSAIRKTVADAIGVKGNGDSLATNMSGGQIWHQQVHQAFQRVFGLARSQKAPYLDIQRCLKTLPPIKFLQLFWSEVLVAASQGELEACRRISTFVLTTPQDSNMPPVLPIFLHIILPSLIVEADKQPPPEQTMSVDLMVAIISSVLNAAIHLEWAMKSALGEDRLVLGQSSTGASRRLALDLRRNRKSNVSNMIMQRLSSSQSFVANFPVFKSELGT
Length969
PositionTail
OrganismHebeloma cylindrosporum h7
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Agaricomycetidae> Agaricales> Cortinariaceae> Hebeloma.
Aromaticity0.08
Grand average of hydropathy0.151
Instability index44.32
Isoelectric point6.67
Molecular weight107173.35
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02366
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     242.03|      88|     494|     321|     436|       1
---------------------------------------------------------------------------
  150-  262 (125.11/79.03)	PISHFHQLtasvselVILLFSCVSDL...SQLSTAqamVYFEDVNYLLTNYR..LTA......DLRQVLDTFLVSL....TLLI.GDDAKSaRDAQlshtiqfslnkgdiLGPSSDTDI............ISLGLLLNHL
  321-  436 (116.92/133.94)	PTVYYTQL.......LLSAFTCLSQSggnSRLWKA...FIVGRLPVLLAKFAevVTAdkatntDLNGALHAGLTAIfrrpDIIIqGDHALS.RDAN..............LDPSLDEDIsrsfsreflqqlVKHNLVVQQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.93|      26|     295|     279|     304|       2
---------------------------------------------------------------------------
  279-  304 (46.58/29.37)	FPSLSFSLFFFKVTYRAHNFGAGDIT
  566-  591 (45.35/28.41)	FSHLGDVVLFVQYTFTRFKFENKEIT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     208.99|      68|     728|      33|     105|       4
---------------------------------------------------------------------------
   33-  105 (109.76/71.56)	AISLEGSG.KVATNLSNSVL...VLYRSYPGDPGLQDYLKAAIQD.....GILPVSTFVATLLqaarsSELHIPATLDTL..CR
  763-  841 (99.23/55.86)	AIGVKGNGdSLATNMSGGQIwhqQVHQAFQRVFGLARSQKAPYLDiqrclKTLPPIKFLQLFW.....SEVLVAASQGELeaCR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.69|      22|     587|     107|     131|       5
---------------------------------------------------------------------------
  107-  131 (33.04/37.29)	ALDAHYSSGQPPIGSvvPfSEPSNV
  708-  729 (41.65/31.52)	AAPSHYDTVQTLILS..P.SCPRSV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02366 with Med5 domain of Kingdom Fungi
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