<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02362

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMNQDRPTELVVDALHSSPKPLANNDQHLGISEPTLEELERELPVVYDGQIPLGDLLSRVVQSVYAELLELVETLPNMSDSARKRTLADWVVKTKKQVVKLYAVAKWSRDAATIQKCMNITAFLMTQNHQFEESIRGLNYAKESLDPARLRNHDLLTSLDVLTTGSYLRLPTIIKKMAIPSTPLTDAEVAQTLFDMEETIRYRLRLEEIIPVEMSRYHIADGRVHFNVPKLFNTSFCLRGGDKNDGWFFVHVEFLITVGGDLTGLQEFPRVPSGMIKRHITDEADARLAFYLHLQPEQAPPPEIPPRPQLPQGVVDAPLVRVFNFLQMMSLSYQLEIMWYQAERMRSLGWGDYLSIKMSPDRKTLMASYWIRAPVPQIPNRPRSKIPLLGGILTIAIIETRGPPQTGPGPARTSRQRAIARLQQKSKLGNARPSDDVEGLRFNVHWEPAKGALGINISLNDLALPPGVVQVDPDNLDFEHMLRTVIQKHSTAILTSFSNQLQHGPNKVFSRPGVVSLILDDETQALRVYLCADQVLIITIDTRTGRLCLRDTGDLASAGGGPRFSLVSDKLNENPSILMDALCRLRLSTIMDLAEQKAKYLGLQCHRRRNIAPEEMAKLGSEARGMLYIQLANFPNHYLVLVVTDERFQYALITTSVIADSMFGSMILEDIAWLNFDRIHDKANILVMDGDSTRREGINHRLEDESSSSLGKNQSNGFNLDIQGLRELYIYCSARVAYINVERQFKIRGIPFTHVNPTLGSLPSPELAQMQSSLARSVPALCVQSKHILSGAPAAEAAMPNIRVIPLNWWSNEKAQVVTCVKLKYVQQPMGKTASGSAVIRPSKRIIYDTTEAVVSFLSENVNTCVDEFLEEWARVSKMVVIAREVAQMSKHTKWHDVRLLSFDLQTVEFAYSRDYTVSISCQDQLSPSGGTFDLEFSRTPPRNGMDMDAEMDNFNPHEDAEPFLRDILRHAHGRLAPSLHCLVTLLRETLPIVVVLEAIRQEAKKNGMILDVFPKAAGWYRLLYTDLKHALDFRLLSNQRIAVLDASHSLFDVQMPGKAVEKDYLVLQPIPQIRDIVTDVVRDGLAGGDLTTGKVAAIDIGVICDAGGVDPLARAIHTQVLKHLKG
Length1126
PositionTail
OrganismHebeloma cylindrosporum h7
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Agaricomycetidae> Agaricales> Cortinariaceae> Hebeloma.
Aromaticity0.07
Grand average of hydropathy-0.165
Instability index45.44
Isoelectric point6.51
Molecular weight126162.79
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02362
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.37|      31|     422|     143|     173|       1
---------------------------------------------------------------------------
  143-  173 (51.90/30.48)	SLDPARLRNHDLLTSL.DVLTTGSY.LRLPTII
  177-  209 (42.47/23.71)	AIPSTPLTDAEVAQTLfDMEETIRYrLRLEEII
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.09|      13|     423|     372|     387|       4
---------------------------------------------------------------------------
  298-  310 (29.37/17.42)	APPPEIP..PRPQLP
  372-  386 (22.72/26.18)	APVPQIPnrPRSKIP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     139.45|      34|     423|     548|     581|       5
---------------------------------------------------------------------------
  548-  581 (56.35/32.97)	LRDTGDLASAGG..GPRFSLVSDKLNEN.P.SILMDAL
  931-  961 (47.03/26.32)	...TFDLEFSRT..PPRNGMDMDAEMDN.F.NPHEDAE
  964-  999 (36.07/18.48)	LRDI..LRHAHGrlAPSLHCLVTLLRETlPiVVVLEAI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     151.99|      39|      40|     766|     804|       7
---------------------------------------------------------------------------
  733-  761 (37.98/20.60)	........AR.VAYINVERQFKIR..GIPFTHVN...PTLGSL
  766-  804 (62.73/38.50)	LAQMQSSLARSVPALCVQSKHILS..GAPAAEAAM..PNIRVI
  806-  846 (51.28/30.22)	LNWWSNEKAQVV..TCVKLKYVQQpmGKTASGSAVirPSKRII
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.58|      16|     148|     902|     917|       8
---------------------------------------------------------------------------
  902-  917 (29.19/19.89)	FDLQTVEFAYSRDYTV
 1051- 1066 (29.39/20.07)	FDVQMPGKAVEKDYLV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     172.68|      53|     772|      46|     100|       9
---------------------------------------------------------------------------
   46-  100 (81.90/70.55)	YDGQIPLGDLLSRVVQSVYAELLELVETLPNMSDSARKrtLADWVVKTKKQVVKL
  847-  899 (90.78/70.99)	YDTTEAVVSFLSENVNTCVDEFLEEWARVSKMVVIARE..VAQMSKHTKWHDVRL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02362 with Med14 domain of Kingdom Fungi
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