<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02361

Description Uncharacterized protein
SequenceMRENSDEKHSENLPVYESHPPAWLPKVHATADLGYVGFHPPRPGQDEDSLSENNVKNGFILGQPVAVEAFSAQAMINESLHSIDTLSKLERLMNDVFIHRADRIPIIPPSTFRIPMRVTLNDAKRQAWFADLANPDVPLHKLGKSVPHGAKGHDLLDLLHSNNVAIPRAVWFLRVFGANETAGLRNKPTYIPTQYSVDWANVVTGYMKKQLVEIALPSAPRLGLNIKQTFKGVLADTDTRDRWMSRFTYCLKLLRTFYAEDLIDHKTFLTWLVQQMITCNLAQAGFLTPLSDEYLDDIMVSRALTRPLVESCLNKLFEIRSTSAHDFLKVTEQLLKLLIQRVCLALPDALVSPKLWNSYSMLLDEIVFEGSASLPHDRYMEQNITDLRYLLSENLSDARERNRALSFYGPITQPSDRLGTAVSDVKLLNSISGDTDMNSITYFREDINDPSFKEKLDMLLTWSVTPLQYGDHRPFAAVTLICIWRNKAHARASKRAITKPNDFLQDQLFDWLDTSEIAGEANSIRDVALLYGKLVKHEIFSYSAYIQRLIARGEPGVCYAEEPASRHRQILNWIPLFKSSSSLINQRKVTLHGARARETPEDVAEREIRKEIRAVLPELFGVAAISKQTSTTLSERCKRLMAATRFEQVRTFRQWLLPFFKTCFLRTDVDGSVLLKSYLVVTELMTFTKCFHSMLDLTLSMLEHCVDAESMDSLLNTFCRHITIWNCMNVMPAIVKALDTAHQVWKLRGVQCRPLLALIMRFDNSRHLSEASRERIESDLAAFTLALRPIVEHAEPIPDLSELLDLLNDDDPNAPSAYANRLWIKYRTSLDWASKVWDSTVTTLRHISEKAFDTEIRRNCALRCGAFLWKVDQHLPNGIDGDVLQWLVGPGRVVVASLNAATWDVLAFVLIYLVVHGALKTTTILRGLIYPAWHMGAGTANQPLISETHLSAANVLCSRLLLGKAESDEMPLFDAQSIRTKRQEVYDEPHFSLLVSSIPTLISLEINKELPESLRLESTSLRCQLCQESGFRQGAYRNLDIIREAFENSPYLIDEDPTSENLSKRAIAGLRMILCDSTDEANIYDWPEVTCLLSPWKIAATTVQMQLQVKKLGRALSQESTSEFATTNLNKLISMLFHHTKTAEEAYYVGEMARGTDTNVASKFINRGFQCMIDLFTEHPSNSTTSVQECFQRVGELLRVLVHISLTFRDSPASSLIVEPQVQDAFIATLENKFKAIEPQALSENNMDSLLLNQQLVLLSRLLQFVLSFRCCWTPQSKDACINLSALLFRLTLRFAIEDNSGMNNYSILIDTLLVLFDELSHDSKSITFDPFRYYPNYTATDIPTDIPPHRRKQIISLLAHLLPASAVTNLVNAHRDSQGNTVYGTPVVNKPWEWIENLGEPSAVDPKDEEKERLHLRYLVKNSGSLSLDTFGARITGDGVKQEMLNEGGQLEGYLRPFEDGMSENVFIRDWRETRWDTEPLSEATIRLRSEHESGAFAGSESSTAHTLRASPSSSVISHSSTQATGSSRQQPSPAQAVRSRPEVIDLDVVQVSSGSVKGKETMKRKASAMTISDDEIEIIEGPVIVRTNTTTKKQKAGKAPAAGKSRGRKK
Length1612
PositionKinase
OrganismHebeloma cylindrosporum h7
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Agaricomycetidae> Agaricales> Cortinariaceae> Hebeloma.
Aromaticity0.08
Grand average of hydropathy-0.225
Instability index42.76
Isoelectric point6.24
Molecular weight181725.53
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02361
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.69|      14|      17|    1501|    1514|       2
---------------------------------------------------------------------------
 1501- 1514 (22.98/12.93)	SESSTAHTLRASPS
 1521- 1534 (23.71/13.57)	SSTQATGSSRQQPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.72|      12|      18|     902|     916|       3
---------------------------------------------------------------------------
  902-  916 (11.17/16.78)	TwdVLAfVLIYLVVH
  923-  934 (24.56/13.47)	T..ILR.GLIYPAWH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.66|      12|      17|     968|     980|       6
---------------------------------------------------------------------------
  968-  980 (18.51/12.81)	DEmPLFD..AQSIRT
  987- 1000 (19.15/ 8.19)	DE.PHFSllVSSIPT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     132.32|      40|      83|     399|     440|       7
---------------------------------------------------------------------------
  399-  440 (63.20/48.70)	RERNRALSFYGPITQPSDRLGTAVSDVKLLNSISGDTdmNSI
  485-  524 (69.12/46.23)	RNKAHARASKRAITKPNDFLQDQLFDWLDTSEIAGEA..NSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      68.68|      14|      17|     286|     299|       8
---------------------------------------------------------------------------
  268-  281 (24.19/13.00)	FLTWLVQQMITCNL
  286-  299 (23.16/12.13)	FLTPLSDEYLDDIM
  304-  317 (21.33/10.61)	LTRPLVESCLNKLF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.00|      13|      19|    1283|    1300|       9
---------------------------------------------------------------------------
 1283- 1295 (21.43/20.83)	NLSALLFRLTLRF
 1305- 1317 (21.57/ 6.80)	NYSILIDTLLVLF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02361 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DVVQVSSGSVKGKETMKRKASAMTISDDEIEIIEGPVIVRTNTTTKKQKAGKAPAAGKSRGRKK
2) EPLSEATIRLRSEHESGAFAGSESSTAHTLRASPSSSVISHSSTQATGSSRQQPSPAQAVRSRPEVID
1549
1480
1612
1547










Molecular Recognition Features






MoRF SequenceStartStop




1) TTTKKQKAGKAPAAGKSRGRKK
1591
1612