<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02349

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMAHHGHTLLVSRLKLPPLCTISYVLFKGPLDAIELARRSIPSRNTSGSLLESLFESVQLSPEPLLYIFRLHSAPAPVDLFATLHFPGLTRVEFSSFTPPTVSSLLPNSHDRTPLSHFYQAALQEWLPNLPRIYFLRLGIQVHHKVFFSYSSDGSPSHLVLHPTLLPTPFLDIASSLPLPPGTPITLLPYATPAYFLATYNGPTAGLITRFHSSLQGIGPGLWDSISPTFIIAWIKVENKQGEDKGITIIYPTALCLSYIPLSTSRSPLDYIPELPAPLQPSPQVAPAVLSISQNLDSPRSYPPRPSLFSSPTSDSLQLFRGLTLSKANDLRQVATEVGSYVDAVARERERERERLKRERETGASTAASPKLTRTSATTPASVPTPISTDSSVIIPQSYIPPPPPPPPSQLQPAISIQSFYPSPPHTVPNTVPALEGKTSPVDESSHAQPMAIPLSTVPEPASQEPSTTNGAYDLFNMDSYNMGMDLDLDDIGIDFDMNMGSMLTTGSSAGATYAPAQGGSMGMEYEDAFTDEDFSFFDAPTRSAPTSASGPHFPPSNRIPSGGTPAHAHTRSTSSGGNISHLLDTLSGPSQQPMMWTPGIEGFTPRSVDHHDSSAADHLLSPGQTPFANATRHDEEDAMHAPASSTSFTPTPLPNVHLERIANRSSSSSSHPTTAAATNHFEPIPFSKYHRDADGKYAVGKFAFSLPSPPPEEDDEHDNEKEKETLLTKGDVTPTTGQPASWMSRSRPKRWRWRPPILRMRSTPVLDATTTAPWSPTGSGGGAAAGVVDVDGGGGGGWRFRYNAATDPRIGVVRKLIGVKRKAPHALAERNLKRTKSMSWPDDDDWGAASTRRLREGADVQSTVAESEEEEEEDEDEEEEEEDIESPMLSRPTTPPPAYLPLGPTLLHTQFQHAHLLPLSTPLRPPGAAVAPINLSHPTAHPPPSVPTPVSPAATMGAANEKSKSLETAAFAIATEVVENPIWGETWRASAVGAKPTPELWSADYRAVASLLEGVPGLESRVSMEDFFELGTPDVSKPLQPLEAPMLSIGKGEAIIQVQPPALRFWEKLGLNPKSGKKDVSAIAIFEDDGEQGQSHVESWLSNVCSAYQGKHYGTMSLGKSGFCAKDGLFPLRFDSTFRKNLASFLTNLVPPQPTLVIFLILPLTVMSLSSPVLRQILSVSKKVLATYRTNNQFCLQFVPQQHLFFGHDRLSAYDSALDLLCSSVYNRILIPVDRIISRRQRLHRGDEKDNIRRYFMGPSFTLARPLYNKVSYVRAAHTSLDVMDRHTLLHVGYHLTACGRWILACCVDQRGEAHDLGVWLTQSPAAAADHEGDGGGGEVLSDEEYAVKRVWDFAVQFAKRTDVEWRVVFTRLGVMTEPELNAWTAHFAARVVPSREQPPLHHTLACVVPDAPWSVLSMVAPPPSRTTSSGRSPSSSKQQTFFTDITSSTYAVFPKNYIPISVPPSHHDLGLSQSMIPEPSTPAISSPSSPAPQLVPHATPFNPPSTAHSSTTCPELSASLNALPHPITILPPHTSILIRVPHASSTSAITMTQIHLLHTSHSASYTQSLQATSSARVPDNAQLLVDVTRNFHELAVLSRVRFKLDGMGGGNRGLPFHLAAVDAMRVALDRDWERLEGGADL
Length1642
PositionKinase
OrganismHebeloma cylindrosporum h7
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Agaricomycetidae> Agaricales> Cortinariaceae> Hebeloma.
Aromaticity0.07
Grand average of hydropathy-0.297
Instability index57.66
Isoelectric point6.01
Molecular weight178439.13
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02349
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     200.81|      44|      44|    1455|    1498|       2
---------------------------------------------------------------------------
  540-  569 (38.08/10.77)	.........PTRSAPTSA..SgPH...FP...............................PSNRIPSGGT.PAH..........A.....H
  886-  937 (32.30/ 7.82)	........SPMLSRPTTP..P.PAY..LPlgptllhtqfqhaH....................LLPLSTPlRPP......gaavAPINLSH
 1418- 1474 (60.76/22.33)	SMVA.PPPSRTTSSGRSP..S.SS...................kqqtfftditsstyavfPKNYIPISVP.PSH..........HDLGLSQ
 1475- 1498 (34.16/ 8.77)	SMIP.EPSTPAISSPSSP..A.PQL..VP.............H................................................
 1501- 1562 (35.51/ 9.45)	...PfNPPSTAHSSTTCPelS.ASLnaLP.............H...........pitilpPHTSILIRVP.HASstsaitmtqiHLLHTSH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     168.11|      41|      44|     595|     635|       3
---------------------------------------------------------------------------
  595-  635 (72.90/34.35)	MWTP.GIEGFTPRSVDH.HDS....SAADHLLSPGQTP.FANATRHDE
  639-  682 (55.43/24.03)	MHAPaSSTSFTPTPLPNvHLE....RIANRSSSSSSHPtTAAATNHFE
  684-  719 (39.78/14.78)	..........IPFSKYH.RDAdgkyAVGKFAFSLPSPP.PEEDDEHDN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     122.36|      33|     303|     727|     798|       4
---------------------------------------------------------------------------
  148-  180 (60.81/11.31)	SYSSDGSPSHLVLHPTLL...PTPFLDIASSLPLPP
  741-  776 (61.55/61.76)	SWMSRSRPKRWRWRPPILrmrSTPVLDATTTAPWSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.50|      15|      15|     988|    1002|       5
---------------------------------------------------------------------------
  988- 1002 (28.20/17.46)	RASAVGAKPTPELWS
 1006- 1020 (23.29/12.80)	RAVASLLEGVPGLES
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     206.11|      63|     539|     785|     865|       6
---------------------------------------------------------------------------
  785-  865 (106.03/89.47)	AGVVDVDGGGGGG.............WRF..RYNAATDPRIGVVRKLIGVkrkaphalaernlkrtksMSWPDDDDWGAASTRRL...REGADVQSTVA
 1326- 1406 (100.08/57.71)	AAAADHEGDGGGGevlsdeeyavkrvWDFavQFAKRTDVEWRVVFTRLGV..................MTEPELNAWTAHFAARVvpsREQPPLHHTLA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.53|      26|     306|      98|     130|       7
---------------------------------------------------------------------------
   98-  128 (38.37/22.33)	PPTVSSLLPNshdrTPLSHFYQAAlQEWLPN
  404-  429 (51.16/24.55)	PPPPSQLQPA....ISIQSFYPSP.PHTVPN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      98.25|      23|     306|     264|     286|       8
---------------------------------------------------------------------------
   27-   47 (30.65/13.46)	.KGPLDAI.ELARRSIPSRNTSG
   60-   76 (24.60/ 9.04)	SPEPLLYIFRLHSAPAP......
  264-  286 (43.00/22.51)	SRSPLDYIPELPAPLQPSPQVAP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02349 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DLGLSQSMIPEPSTPAISSPSSPAPQLVPHATPFNPPSTAHSSTTCPELS
2) EDFSFFDAPTRSAPTSASGPHFPPSNRIPSGGTPAHAHTRSTSSGGNISHLLDTLSGPSQQPMMWTPGIEGFTPRSVDHHDSSAADHLLSPGQTPFANATRHDEEDAMHAPASSTSFTPTPLPNVHLERIANRSSSSSSHPTTAAATNHFEPIPFSKY
3) EVGSYVDAVARERERERERLKRERETGASTAASPKLTRTSATTPASVPTPISTDSSVIIPQSYIPPPPPPPPSQLQPAISIQSFYPSPPHTVPNTVPALEGKTSPVDESSHAQPMAIPLSTVPEPASQEPSTTNGAYDLF
4) GKFAFSLPSPPPEEDDEHDNEKEKETLLTKGDVTPTTGQPASWMSRSRP
5) HAHLLPLSTPLRPPGAAVAPINLSHPTAHPPPSVPTPVSPAATMGAANEK
6) PHALAERNLKRTKSMSWPDDDDWGAASTRRLREGADVQSTVAESEEEEEEDEDEEEEEEDIESPMLSRPTTPPPAYLPLGPT
7) STPVLDATTTAPWSPTGSGGGAAAGVVDVDGGGGGGWRFRYNA
1469
532
336
700
913
824
762
1518
689
475
748
962
905
804










Molecular Recognition Features






MoRF SequenceStartStop




1) KRWRWR
749
754