<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02337

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSTHKRVQRFKGGFVFGRHPTLASRNSYPIPRYIPDFYSMGAVKLRLRPLIFCHLQVLLASPRDHSPCLVIHPILTITPYLPLDQTLPLPSGTPIILLPYGTPAYFRTTYEGPTSSLVAQFKTALHGLGVSDWENTWHDDGSSRQGGDVRRPMFIIAQLTIENKQGVDKGLLVIYPTALCLSFSPSTSSLCQPSAHMLDLPTPLQPSPQVPPAIPTQDKPYGIYSSTSDSLQRIRLFTLSSHRDIHRVADEVGSYIEAVAREREKERERLKREREEGASSSPSLSRVVAPTPITRSSTSSVDALDQLPLQSAPSFQSSFYPSPPLANTNAMDAQTSPGADDSPHLGDANDTLGADNIPVEPVSEDPFDNIESSWAQSSQEYMGMDLDFDIGMSLGIAQGSNERDVYVDVRHSMDFEDAFTDDDFSFFDQPSRSVPPAFVAPTATPAVIPDPPSDVFLKGMSKAERTVIKAEEHSTPFEHHTADALPWTHADTLFSPIHLDTELPELSPPSGQTPEADSSPTTPDVQLDPSVVIRDTTGTSTSLLASPFDPIPFASHHRTSDGKYLHGKFALSSPKRQDFSGSRADSGLLDPSSPTQEEGWKAQYDAITDPRIGVVLKLKKKREPSQTTNNELCSPSWMQEEEHVMVLPDEDASSEEESDGVDPGFSPPGTPPPPHLPLGPTLLCTHFEHALLLTIGVSLRSSDSANTTLSNPVIPISVPTPVSPAATLGALAERLRSLEAVVNAVASEMVENSVWAEAWRSIIPSSQLSQSDVWPSEIKYASQLLTLVSESGAISNLSSLFDICECPQALHFVGIPKRLTAASLKPLESPHIAIGKGENVIHALPTALRFWEKLGLCPRGGKKEVSVFVLYDKEGDGNQRELQIDSWLESIKASYTVRRTPSYGNLNLGRCHHGHHGSKDGHFPIRYDTSLRKSIASIFSNLAPAEYHYIFLFLIPNSIMTFTSPVLRQAIAAMKKGLKDHAEINAIYELVPEHLVFGPLHSPSEHELFITNICSSIYNKTPSIVSRFTSRNLLGSYTIRGRIEEPDFTLARPLPYKVSFTREAQASLDVADQCTLVHVGYQMSACGKWLVAACIDQRGEAHDVGVWLTRTSSDVDEVEVSDEAYIVGKIWEFTQSFTKTADLRWRIVITKYGAMGEDELDAWIHHLENEMDRFSRPLWHASILCTEVNAPWCIPNIRRDSSNPHPPSSNSATLTKDSIFIDISSQTYMLCSQKRFPLSLPINTSFRHSVIAESSSDALTESELVSSEKTEEKVRIPHPVTLLPRSSTKLIRIPSSSATISMLDIHLLYITPSHPDLPDESKFNQEITRNFYELSLLAALRWKLNANPILPFHLGAVEVMRLALERDGELLEAVLDG
Length1377
PositionKinase
OrganismAmanita muscaria Koide BX008
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Agaricomycetidae> Agaricales> Amanitaceae> Amanita.
Aromaticity0.08
Grand average of hydropathy-0.281
Instability index55.73
Isoelectric point5.40
Molecular weight151933.61
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02337
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.76|      13|      15|      49|      62|       1
---------------------------------------------------------------------------
   49-   62 (19.92/14.25)	PLIFCHlQVLLASP
   67-   79 (24.84/13.43)	PCLVIH.PILTITP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.48|      27|     102|     182|     208|       2
---------------------------------------------------------------------------
  182-  208 (54.18/26.27)	SFSPSTSSLCQP......SAHMLDL..PTPLQ..........PSP
  279-  323 (30.30/11.57)	SSSPSLSRVVAPtpitrsSTSSVDAldQLPLQsapsfqssfyPSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     159.42|      43|     101|    1118|    1160|       3
---------------------------------------------------------------------------
  560-  579 (20.74/ 7.02)	...SDGKYLHGK...FALSSPKRQDF..................
 1118- 1160 (73.02/42.84)	VEVSDEAYIVGKIWEFTQSFTKTADLRWRIVI.TKYGAMGEDEL
 1221- 1264 (65.66/37.79)	IDISSQTYMLCSQKRFPLSLPINTSFRHSVIAeSSSDALTESEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     305.97|      66|      76|     415|     480|       5
---------------------------------------------------------------------------
  415-  476 (99.01/48.65)	..................FED..AFTDDDFSFFDQPSRSVPPAFVAP.T............................................ATPAVIPDPPS..............DVFLKGMSKAERTVIKAEEHSTP
  477-  552 (96.53/47.22)	F.EHHtadalpwthadtlFSP..IHLDTELPELSPPSGQTPEADSSP.T.............................................TPDVQLDP................SVVIRDTTGTSTSLLASPFDPIP
  553-  635 (34.84/11.69)	FaSHH............................................rtsdgkylhgkfalsspkrqdfsgsradsglldpssptqeegwkAQYDAITDPRI..............GVVLKLKKKREPSQTTNNELCSP
  640-  716 (75.59/35.16)	E.EEH................vmVLPDEDAS.SEEESDGVDPGFSPPgT............................................PPPPHLPLGPTllcthfehallltiGVSLRSSDSANTT.LSNPVIPI.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.63|      20|     687|      27|      48|       6
---------------------------------------------------------------------------
   27-   48 (33.18/23.89)	SYPIPryIPDFYSMGAVKLRLR
  717-  736 (34.46/18.00)	SVPTP..VSPAATLGALAERLR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     146.73|      61|     175|     784|     897|      11
---------------------------------------------------------------------------
  784-  830 (46.79/28.02)	...................................................LLTLVSE..SGAISNL.SSLFDICECpQALHFVgIPKRLTaasLKPLESP
  854-  872 (14.91/65.13)	LGLCPRG..GKKEVSVFVLYD................................................................................
  908- 1003 (85.03/42.70)	LGRCHHGhhGSKDGHFPIRYDtslrksiasifsnlapaeyhyiflflipnsIMTFTSPvlRQAIAAMkKGLKDHAEI.NAIYEL.VPEHLV...FGPLHSP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02337 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) APSFQSSFYPSPPLANTNAMDAQTSPGADDSPHLGDANDTLGADNIPVEPVSEDPFDNIESSWAQ
2) HLDTELPELSPPSGQTPEADSSPTTPDVQLDPSVVIRDT
3) IEAVAREREKERERLKREREEGASSSPSLSRVVAPTPITRSSTSSVDALDQLP
4) PKRQDFSGSRADSGLLDPSSPTQEEGWKAQYD
5) VLKLKKKREPSQTTNNELCSPSWMQEEEHVMVLPDEDASSEEESDGVDPGFSPPGTPPPPHLPLGP
312
498
256
574
615
376
536
308
605
680










Molecular Recognition Features






MoRF SequenceStartStop




NANANA