<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02320

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMQPTLSSTEDIGSTKTNGHTKHEEINGKPLNAVQETVKDEQDERVVLPVEMASMVPLKVLIGKLIHKAHADLVTLSETLPSMGDVEKKRQILTYTTFVRKQFLKLLVLVKWAENADDIQMCQVIRDAARLRNFDIPTAVDVLTTGTYQRMPTKIKDMLTPTPLTDEEVLETFQNMNDVIRMRMITTEVLPAPMRKYRIENGRIYFSVQNEFEVALTLMGHSSNRRWWIVSLDVFVQATSVGGASSEDVDISLNDSQKQHLRVNAQKQLVPPNADEPTRLFFPLVNMYDYLHLCCLNMQIEILYIQAAMLAKTRWMNQLKVQMNQDRTKLTVVYWRGGSPAAHWARPQANSKANQSTVVEICVSHSDQQPPQPENVAVAVRDELKGLIQKAGIGASITLSDLTANEQPRVLSLLKYPKNCLDVFWDDSSSLHTKEKLLDSSNLNLEQLVLHVTNYHGKCIIDKFRELLIAQKDFLEENGLQLADDDTSVSPQSAALDENRTKRPSLVVRYRHQRYISIECDARTGNVKASEASDGCSEGDFKLRGLEERLNNDPEDIARHLLWLRSEVVVREIISLAKQLNLQPYHPSQMNLRPEDLQKLFGDILTDSATATTTAANNTKYPSHCMFLQFSQFEDWYFVIATVRNKFKAWLCCINKTYDQNGLYQAIVDLAHFDCNQVWKDQFIEKSTNKNIDASATNTHNKRKIDAEEEDGPSINDDVKRRRMSLRKDDNESISLAKVDNLSIDLRFLAKLDSLCRAYITNRMIELQLQAFKGSLKYHMRPLLQSLSSMETQVMNHPAADKMEVVCVSQRDLLKACAYHLAEDGTKREKPLETIPWIEKILPSMKNDVLIRSFGWWDCGRGDCYVVVQDKFDWKHLELQDSDLGDNISLDKTTNVLSFTYPNIDTCIDKFLMDWERIFMMANLTRQMASVWLKKYKDELSFNPTNLQELSFSYAKASLLSIKEYAFDPSKLIRLQDFKCTIKWSSTGKGHPRQYNIELDTTDDTTKAKATALPRLNSRNPHWRIASFLRDVLNEKKDLIHFVQTLPLMACLERLEVECAQKGEIGKVSIIPRAYDSVRIIFSAMHAIDIRFTDKATICVSDAAYHHLFYSSHTTAVDTFIAPQPYVVQLPQQQPAEPSSEGMKPIKVTQQFKFSPFDQFAGLLESMETWIFSPEPEHVDRWYVSDQKMEPNAVSFQHGLLCSASLCQGILHKLQQALLIMAILEAIPEKLIVAFVTILITYLQATTNFYILGPALGGWTSLRALKILSPMNILLISLYVNYYLACTTDPGTTPDEWEPPHSILNPAEDAVLKVGITGPRFCKKCDAYKPPRAHHCKYCGKCVLRMDHHCPWIGNCVGFGNYSHFVRFVYSVIGCCSYGCYLLLWRMQRILDAWNNPWVVAKPGTFEVVMIVFNIMLIVVVVFAVGVLAVYHTYCLFKGQTTIEGWERTKTKRLINKRQIESVDFPFDVGFYKNICSVLGDNPVLWAWPSASKGDGLRYSVKPDTDPLIPYSWPPRDPKDLGPSFIERIEQEQANDGPKLVRRDSEGYLVKEITMEDRMRMLHGQDYAAPSLEQQMHEQLLQGQQREVDSNGYFYDSASVSDGFTDDEE
Length1608
PositionTail
OrganismParasitella parasitica
KingdomFungi
LineageEukaryota> Fungi> Fungi incertae sedis> Mucoromycota> Mucoromycotina> Mucoromycetes> Mucorales> Mucorineae> Mucoraceae> Parasitella.
Aromaticity0.09
Grand average of hydropathy-0.302
Instability index44.36
Isoelectric point6.12
Molecular weight183547.36
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
palmitoyltransferase activity	GO:0016409	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02320
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.10|      13|      17|    1123|    1137|       1
---------------------------------------------------------------------------
 1123- 1137 (19.76/20.18)	QPyvVQLPQQQPAEP
 1143- 1155 (23.34/14.89)	KP..IKVTQQFKFSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     387.52|     122|     357|     510|     635|       2
---------------------------------------------------------------------------
  372-  473 (81.76/48.11)	..............................................PENVAvavRdELKGLIQKAGIGASITLSD..........................lTANEQPRVLS.LLK.YPKNCLDVFWD...DSSSLHTKEKlldssnlnleqlvlHVTNYHGKCIIDKFRELliaqKDF
  510-  635 (204.17/143.85)	RHQRYISIECD...ARTGNvKASEASDGCSEGDFKLRGLEERLNNDPEDIA...R.HLLWLRSEVVVREIISLAK...........................QLNLQPYHPS.QMNLRPEDLQKLFGDiltDSATATTTAA..............NNTKYPSHCMFLQFSQF....EDW
  670-  786 (101.59/61.24)	AHFDCNQVWKDqfiEKSTN.KNIDASATNTHNKRKIDAEEEDGPSINDDVK...R.RRMSLRKD..DNESISLAKvdnlsidlrflakldslcrayitnrmiELQLQAFKGSlKYHMRPL.LQSL......................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.12|      14|     357|     292|     306|       3
---------------------------------------------------------------------------
  292-  306 (23.95/21.18)	LCCLNMQIEI..LYiQA
  650-  665 (24.17/15.48)	LCCINKTYDQngLY.QA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.66|      12|      22|     938|     949|       5
---------------------------------------------------------------------------
  938-  949 (21.25/12.08)	ELSFNPTNLQEL
  963-  974 (21.42/12.23)	EYAFDPSKLIRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     268.12|      76|     513|     793|     874|       6
---------------------------------------------------------------------------
  793-  874 (129.69/96.65)	VMNhPAADKMEVVCVSQRDLLKAC.......AYHLAEDGTKREKPLETIPWIEKILPSMKNDVLIR.SFGWWDCGRGDCYVVVqdkfdWK
 1302- 1385 (138.44/87.10)	ILN.PAEDAVLKVGITGPRFCKKCdaykpprAHHCKYCGKCVLRMDHHCPWIGNCVGFGNYSHFVRfVYSVIGCCSYGCYLLL.....WR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.76|      16|    1376|     175|     192|       7
---------------------------------------------------------------------------
  175-  192 (26.37/26.58)	MNDviRMRMITTEVLPAP
 1554- 1569 (32.38/24.61)	MED..RMRMLHGQDYAAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.03|      16|     359|    1090|    1109|      10
---------------------------------------------------------------------------
 1072- 1087 (28.07/12.56)	RAYDSVRIIFS..AMHAI
 1090- 1107 (24.97/25.13)	RFTDKATICVSdaAYHHL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02320 with Med14 domain of Kingdom Fungi
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