<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02317

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMSQEPTAKRIKLSLEPAIDNNVVDITNAGQEILKTDTSLPEKLMQSVDRIWFERGEWKDISEKSLMASIEKRKQQPESKKNQQVDAENALPSMTLPPGFDIAKLRESVINKLFHAKSEIDVALDVINILAAGNRGSSAAVKDLVLPAGSLTATYVTKPKQTTKSQLESVQLNLGLKRKKQKQASDFLKKSASALKNLVEKEQVFWDEALDLRRNNWQIQANSNTGASFFVQYGYADVGSDFNEQSVGELKRTSEDDETSDSMLEMSLPHDTCRKVAVRISQSHMGKLGLGGQADFSEGMLGILEDRDAHVVDQDKESIDNQEEGVVEIVISATTAYVDSLPSTSHSKIQNQLAEAHSTVFDAELFSDILAEAQALNSNVRFPDDEIVINIDGQIELHVSKVSVICQRKQHTKLTSQQIVSRSIDLSFRLLLLQHQRFNLWKTKAKTLSSNHKIHQLLNDTFVASSTASSAATSVNASAVNAPTPTNSGGGGGTSGTPAPTPITAASGNVLSTVGTSGSVATAGRARTRLAATVCDLPKQIPILLPIMSLTRFWLQFDRIRHVTNKIIQEYHSLSISVHYKFADDHQTQTNTRPYDTYPGHGQVALCLGLSILRGPSLHFNISQSGGISVCLLQTAIALQNVSEFEAFLSREMKVICLRTVCDVANDLVKSQQLWQVDQVDEAIHGSVWWQSGTRNWRNITVRVLKSYLEFRLNATQNQQESIYMLELNQLAAPMHFKEKVYVTIKEIIKDGQQE
Length754
PositionHead
OrganismParasitella parasitica
KingdomFungi
LineageEukaryota> Fungi> Fungi incertae sedis> Mucoromycota> Mucoromycotina> Mucoromycetes> Mucorales> Mucorineae> Mucoraceae> Parasitella.
Aromaticity0.06
Grand average of hydropathy-0.324
Instability index41.21
Isoelectric point6.29
Molecular weight83377.31
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02317
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.32|      27|      52|     184|     211|       1
---------------------------------------------------------------------------
  184-  211 (39.64/32.21)	SDFLKKSASALKNLVEKEQVfWDEALDL
  239-  265 (45.68/31.60)	SDFNEQSVGELKRTSEDDET.SDSMLEM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.58|      16|      25|     472|     495|       2
---------------------------------------------------------------------------
  480-  495 (32.81/27.61)	NAPTPTNSGGGG.....GTSG
  497-  517 (25.76/ 7.25)	PAPTPITAASGNvlstvGTSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.31|      16|      23|     434|     449|       4
---------------------------------------------------------------------------
  434-  449 (28.80/14.99)	HQRFNLWKTKAKTLSS
  454-  469 (26.51/13.35)	HQLLNDTFVASSTASS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.20|      21|     126|     532|     559|       6
---------------------------------------------------------------------------
  532-  559 (26.08/36.48)	TVCDLPKQIpillpIMSlTRFWlQFDRI
  659-  679 (38.12/23.81)	TVCDVANDL.....VKS.QQLW.QVDQV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.47|      16|      24|     297|     312|       8
---------------------------------------------------------------------------
  297-  312 (27.26/18.72)	EGMLGILEDRDAHVVD
  323-  338 (25.21/16.80)	EGVVEIVISATTAYVD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02317 with Med17 domain of Kingdom Fungi
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