<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02311

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMLTDSSLTNILVVSGVSQIRYRVYNQHVTRDSLDKFWSNPPSDVVNKDMTLLKAYTEMIALSIPSFWRVRCESAEPGGDLELELWVFWFDERHTGKIDANDNLYALDETKVGSFTWENAYSKIQSPTASPGASSAQSNTCVPVTVSDEYKWFIKSVRNLIHVQFKKNGSFPLGEFYIFPNTDQDVIADVKTSSTSPPSLSQLTNSVLCCSYSIYLASTNLILQPNTRRMRLRPITTQTIRNRGRKVIISPTGETMMIAHNAQPLSPQIEESILKKWSLLLDIPYNHLIQCSPTQNASNQQSQQQQQQQQESQQSQQQPKQSVQQQLPNLVAIKSATSGDESYYYPSCLIFVSSSSKISPNAMAGVNGLFAFNQGFSEDLGDKWHRWSWSERISNFWEYTCPRESTTAVVLDTLSVDNGQNSNAGLLQRAISEPVIASPLMAAKSVATPGSATGIQRTDMSTPSSSTHTCDDDDQQQQTQNQLQQPQQQSHSKSRSRYQADVSLVDFALAHFSVPNSADELVEYPILYNHTSVTSQPNDNTIQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQYMPQQQQQQQQHPLQHPPQQELHGINSNQNSMANNPGYQSPQMTNLGLDAYGMVESMGVDSMVLDMPDRWGNDGMDDLDAFDFGVTDADFDFFESSGPATTASAPAQSTTTLLDDATILNEIPKDGLLLQGVKSENVDIIGDLMDIDQKQQQEILDQQQEHDMSVTPLQVSMAQHDRFGSNNVFELVKQEQGAFISSSSPPPPPSPPPQQYYHQQLFVPPQFAPIKMESVVNDAKYFQGGKFTYPAPNTQSPGKRRQNKDYRPDYVPAMRSSKRNRRKSSKTLLLDTINKENKPLELLENINSNDEQQIISKSASTQSMQDHISSSEEEDEDDDDDDDSSSSGDSSHQEESDNDDEQDNDAENVGNGNGQDYDDDDNEEDMSCKITRAMNSLSLAQSKFVGKLTRLDAVADAVKTRMDVDQTLMAMDYDSPFARTVTDSVIHVAGTRIDVNEHEETRALDYLCQQAVMGGYPFSGGIEAMSSNGFEANEGESAKVVIARRRNLLQKYNGDTIHVPSTPSDVEFMNQNFKNVLADIFYQQKKSTNSDLDAMCIDSLPLPASVTVKGPLNVQDYYELSETNQAHSKYGKYQVKKRRPAEPNLGTLHPPNIAVNRQDDSIEGTFKLIMFWEKLRLEPYSSKKQVSYFVVYPKNESIENGIAHFFKGLSTVYETCQLGVHHPGSAGPYQNGLVPVPLLPQLENESFHDRQLRSYMTECQNFGSTLGGAMAENMHIVIYMINPATHLASHLDLSRCFSRMKAAYSHACAPAPPGGSRMPDKNRARLVLQLMPIEHVLRATSFGGCVKFGMKQVAFSVYSKCHAVVSRQHQVVSNSSKPDMCPISDLYAPPFVLSKPIPSQIHFKLKKAISAFPTIMESHAVLHMGYTFSMDKRWMIIVWTDNQGEMIEFAVLDNHRHNLPLSSVFEEAWSRTKQISKRTGFAWTFVICKMGLVFEDELGAWISCLPNNEHVAIVSLDMESTLYVNTTNVDAMMNDILTPTDALNTSTPTMMNAASGAKKTFSDTSENGQTKALLLNHRVAYSNKRERMSFGILGLDSISKEDWMIPLASGYMIHTPPPTENPNNELFNCNPLVLEIHLVYNQTSHSAYIIVSLSTSLLSRDYPVYY
Length1696
PositionKinase
OrganismParasitella parasitica
KingdomFungi
LineageEukaryota> Fungi> Fungi incertae sedis> Mucoromycota> Mucoromycotina> Mucoromycetes> Mucorales> Mucorineae> Mucoraceae> Parasitella.
Aromaticity0.08
Grand average of hydropathy-0.580
Instability index57.40
Isoelectric point5.14
Molecular weight190143.97
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02311
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     146.87|      15|      15|     542|     556|       1
---------------------------------------------------------------------------
  302-  316 (29.79/11.37)	QQQQQQQQESQQSQQ
  477-  489 (24.63/ 8.17)	QTQNQLQQ..PQQQS
  541-  555 (31.61/12.50)	IQQQQQQQQQQQQQQ
  556-  567 (27.28/ 9.81)	QQQQ...QQQQQQQQ
  568-  582 (33.56/13.71)	QQQQQQQQYMPQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      94.26|      21|      40|     896|     916|       2
---------------------------------------------------------------------------
  896-  916 (35.85/22.13)	DHISSSEEEDEDDDDDDDSSS
  918-  937 (28.98/16.24)	GDSSHQEESDNDDEQDNDAE.
  938-  957 (29.43/16.63)	.NVGNGNGQDYDDDDNEEDMS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     336.59|      97|     277|     364|     467|       3
---------------------------------------------------------------------------
  364-  467 (151.71/139.65)	GVNGLFAFNQGFSEdlGDkWHRWSWSERISNfweYTCPRESTTaVVLDTLSVDNGQNSNAGLLQRAI.SEPV.IASPLMAAKSVATPG..SATGIQRTDMS.TP...SS.STH
  599-  648 (38.54/19.07)	......................................................GINSN....QNSMaNNPG.YQSPQMTNLGLDAYGmvESMGVDSMVLD.MP...DRwGND
  649-  750 (146.33/108.48)	GMDDLDAFDFGVTD..AD.FDFFESSGPATT...ASAPAQSTT.TLLDDATILNEIPKDGLLLQGVK.SENVdIIGDLMDIDQKQQQE..ILDQQQEHDMSvTPlqvSM.AQH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.80|      15|      40|     979|     993|       4
---------------------------------------------------------------------------
  979-  993 (25.03/17.28)	TR..LDAVADAVKTRMD
 1008- 1024 (20.78/13.09)	ARtvTDSVIHVAGTRID
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     167.37|      48|      75|    1296|    1343|       5
---------------------------------------------------------------------------
 1268- 1291 (25.11/10.89)	.........................LLPQLENESF..HDRQLRSYM..TECQN
 1293- 1340 (82.69/53.26)	GSTLGGAMAE.NMHIVIYMINPATHLASHLDLSRC..FSRMKAAYS..HACAP
 1341- 1391 (59.57/36.24)	APPGGSRMPDkNRARLVLQLMPIEHVLRATSFGGCvkFGMKQVAFSvySKC..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     106.86|      31|      36|    1161|    1194|       6
---------------------------------------------------------------------------
 1161- 1193 (44.04/35.06)	..............GKYQVKKRrpaEPNLGTLHPPNIAVNRQDDSIE
 1194- 1229 (29.68/15.09)	GtfklimfweklrlEPYSSKKQ....VSYFVVYPKN.......ESIE
 1231- 1261 (33.14/17.79)	G.......iahffkGLSTVYE....TCQLG.VHHPGSAGPYQN....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.33|      14|      16|     499|     513|       7
---------------------------------------------------------------------------
  499-  513 (20.23/15.67)	ADvSLVDFAL..AHFSV
  517-  532 (21.10/11.32)	AD.ELVEYPIlyNHTSV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     122.25|      34|      41|     776|     810|       8
---------------------------------------------------------------------------
  776-  810 (60.90/39.45)	PPPPSPPPQQYYHQQLFvPPQFAPIKMESVVNDAK
  820-  853 (61.35/35.55)	PAPNTQSPGKRRQNKDY.RPDYVPAMRSSKRNRRK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.90|      10|     278|     317|     326|      11
---------------------------------------------------------------------------
  317-  326 (18.57/ 9.02)	QPKQ.SVQQQL
  587-  597 (16.33/ 6.82)	HPLQhPPQQEL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02311 with Med13 domain of Kingdom Fungi
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