<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02305

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMHDPEVRPAPSHPLKIRIHRDSISKGAPSPTTLVNGNPPINGKPEPVEDDEPLPRTFMGQVPLGVAVSRIVQNAYAELGNMAETLPSQSDHDRKRHIFQYVLTTRKGFVKMYVATKWAENARAVQTCLDIMQYCNRAGEQLQLSSAHLNTIAKALGSLRIRNADLLTALDVLTTGTYRRLPSITTELYTPQKPMSKEDVVKVMRDADAAIRLRLRSTELLPTEMNSYRVADGRVYFTVQNRFMASFTVLGGTTDDPWWCADVEFLFELKGERSTAVQYPRIPPKQMRSLIQQETNALLAHIHNQRAAQIAEGNDLTSINRNSDVVDAPLIRAFNFLQLLSLTYQLEILHSQANLMRNMGLADVLTIELAPDRKSMKIWYWVTKNRRAGQPPRKPDLPLPPHGGLITISIQLTSEAQRRELAKEREQQRKSRGGKARPGLVSQTGLLSSFPGASLSQPDLRRPKGGQSWAVRVREDLERRSKLAAHASVRAGADAKSSSANVSGAASGSGLGGDVGGVRPSDEVENARFVVKWEPVADWLGVSVHREAGDEDDLQVDASALSFATIYHNAIRKHSDAVTRALHTQVPDAELKPFGPAGNLAMVQSRILVSISPRNGFVLVQDTADMASPGRVGRFTQAGEAVSRQPQALAEQVALLKFAIIADSVEQQVRFLGYPCTRNRGFPPRYQVLIQRFGHGARHFLFTPLAGFPSYDVVIIVADEGFRYALIETEVVGGYASWKDGTLLDVESMRRHKATVGAEVVPLQGQARPDFEIDGQTLRDIHAYCRARVSYALVEAQLRHLALPYTIAYNTKPGSAVVTPPGRDYPLSQSIPALTVSATDLFRKGHTLGDKDKDKDVEDQVAIEVIGWWNPTASCQVATSVRLKYAPPVSSAKTKSRGGVLRITPRLYYNTLTHVVTFVSESVEGCVGSFLAGWMSVRRLIVIAREIVKMHKTRHWRDVKLLSSDLQQVVFQYFQDYTLSIRWRPAPAQNELLANAQNDSGSYELSFSRLNQTTPWNPHSDLESHFTRRLQDDLAAGDIASFAMLLRDSLPVLLEINRIANHASISARLDIFYKAVGWYRVLIDSRYGLDFRLLSRRRLAILDATQSLDRSILTPIPLIEGVIKRLVPECQLISLSKGALVSFDEDGTRLQDVGVKFVERVIRVLSMGEAGLS
Length1172
PositionTail
OrganismThanatephorus cucumeris (strain AG1-IB / isolate 7/3/14) (Lettuce bottom rot fungus) (Rhizoctonia solani)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Cantharellales> Ceratobasidiaceae> Rhizoctonia> Rhizoctonia solani AG-1.
Aromaticity0.07
Grand average of hydropathy-0.254
Instability index44.68
Isoelectric point9.33
Molecular weight130149.03
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02305
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     325.64|     112|     756|     245|     371|       2
---------------------------------------------------------------------------
  245-  371 (161.84/167.03)	SFTVLGGTTddPW.WCADVEFLFELKGERSTAVqyPRIPPKQM..R.SL.IQQETNALLAHihnqraAQIAEGNDL..TSINRNSDVVDAPLirAFNFlQLLSlTYQLEILHSQANLMRNMgLADVLTIE.....LAPD
 1005- 1128 (163.79/119.56)	SFSRLNQTT..PWnPHSDLESHFTRRLQDDLAA..GDIASFAMllRdSLpVLLEINRIANH......ASISARLDIfyKAVGWYRVLIDSRY..GLDF.RLLS.RRRLAILDATQSLDRSI.LTPIPLIEgvikrLVPE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     181.16|      57|      61|     393|     451|       3
---------------------------------------------------------------------------
  393-  451 (87.16/58.30)	KPDLpLPPHGGLiTISIQLTSEAQRRELAKEREQQRKSRGGKARPGLVSQTGLLSSFPG
  456-  512 (94.01/54.23)	QPDL.RRPKGGQ.SWAVRVREDLERRSKLAAHASVRAGADAKSSSANVSGAASGSGLGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.33|      20|      24|     680|     700|       4
---------------------------------------------------------------------------
  680-  700 (36.13/26.43)	GFPPrYQVLIQRFGHGARHFL
  706-  725 (37.20/22.32)	GFPS.YDVVIIVADEGFRYAL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02305 with Med14 domain of Kingdom Fungi
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