<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02300

Description "Plexus, isoform D"
SequenceMMEWLPRGLPSIHAPIPICVPPKAGQKRPATSPAPHIPVPHHLQTPPGGGAGGLPGSSVANSPIPSSAGGNALMNHALPNNHIGTPSPQQQHQHQQHQQQQQQQQHQAQQQAQQQAVAAAVQQQLAAGVGLPPGAIGAASASSRGSFAAALRTLAKQADIKEEDVGGDRSVPTSGAGGPPPSSSGPGSLNSVAGRVGSERPGEDRVSSNKKRSPPSPQPPEKIARLSHTPQTASLQPELLARSGFQPYRSDERLMHPAGAFPLEAYSHFAGLQGIPPAFLNPAGLPYTEQLYLEHRYQLFRAAGAHPSHPHAAALYPQMASPYSHLYSMMPGAALGISPAMHDRMKLEEEHRARLAREEEREREIQREKERELREQREKEQREKEQREKEQREREQREKEQREKEARERKLRDEERERERERQQLLTASHHYSNQLYSPLNRNLLGSMIPHLNMSLRGPPGALHGLPGMSHYHAAAANAQRQSPHGAMGLNLGMAGLPGVPPLGGHGPNLQHHLQQAAMGLAHPGAAGLTHPGFSAAALGLGAHPHSLNLSHPHMSPHHPASLAHQLPPHTSSAGGGGLSNSIPVTASSSLSASSPHTSLNLTSSVKLSADQVPTSTPSGGVSGSGMPPTTSSSHIPNMGHYYHHGHLAAMHAAAAAASGMTPTAAHQQQPLSLPSSPKITPPITPSSSANGGRAGGSPHAMRHHIAAAVAAAAQQSAMIDKAATPVTHEPTTLDLTGSNSNSSNQAPSNASSGQPTNHEVNGAESNGASQTESKEHLAIKEDGHKSSPPPVALEKKPATPNAAADKPIHPDSSPENSSRRSASPQSDANNSLPAVSVTAAASGKCKEETPKILDSDTTATTKTDIEEEKQRARLSVSPTPTAPKIMVASPDTVSTSGGVTSTTSGTTPPPVVSSSTSSAGKAPALTSDEVSTSAATSAAEPTR
Length944
PositionKinase
OrganismDrosophila melanogaster (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora.
Aromaticity0.02
Grand average of hydropathy-0.699
Instability index63.05
Isoelectric point8.75
Molecular weight98673.22
Publications
PubMed=10731132
PubMed=12537568
PubMed=12537572
PubMed=12537573
PubMed=12537574
PubMed=16110336
PubMed=17569856
PubMed=17569867

Function

Annotated function 
GO - Cellular Component
nuclear matrix	GO:0016363	IDA:FlyBase

GO - Biological Function
GO - Biological Process
imaginal disc-derived wing vein morphogenesis	GO:0008586	IMFlyBase









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02300
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      98.27|      22|      23|     374|     395|       1
---------------------------------------------------------------------------
  350-  374 (27.48/15.45)	EHRARLARE.EEREREiQREKErelR
  375-  399 (35.60/21.95)	EQREKEQREKEQREKE.QREREqreK
  400-  422 (35.20/21.62)	EQREKEARERKLRDEErERERE...R
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.96|      16|      23|     517|     539|       2
---------------------------------------------------------------------------
  446-  461 (25.70/ 6.73)	GSMIPH.LNMSLRG..PPG
  520-  538 (20.25/ 6.16)	GLAHPGaAGLTHPGfsAAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|      84.56|      14|      15|     586|     599|       3
---------------------------------------------------------------------------
  562-  572 (19.33/ 6.11)	SLAHQLP.....PHTS
  586-  599 (25.21/10.58)	TASSSLSASS..PHTS
  603-  616 (20.76/ 7.20)	TSSVKLSADQ..VPTS
  617-  632 (19.25/ 6.05)	TPSGGVSGSGmpPTTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      91.53|      23|      23|      10|      32|       4
---------------------------------------------------------------------------
    6-   24 (27.16/ 6.51)	....PRGLPSIHAPIP..I.CVPPKA
   25-   49 (34.10/10.28)	GQKRPATSPAPHIPVPhhL.QTPPGG
  175-  196 (30.27/ 8.21)	GAGGPPPSSS..GPGS..LnSVAGRV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      88.19|      20|      23|     730|     749|       5
---------------------------------------------------------------------------
  730-  749 (32.49/12.67)	EPTTLDLTGSNSNSSNQAPS
  755-  774 (31.77/12.23)	QPTNHEVNGAESNGASQTES
  790-  808 (23.93/ 7.45)	PPVALEKKPATPNAAADKP.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.06|      17|      23|     876|     898|       6
---------------------------------------------------------------------------
  673-  689 (29.35/ 8.73)	SLPSSPKI...TPPITPSSS
  879-  898 (25.71/20.93)	PTPTAPKImvaSPDTVSTSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      95.18|      23|      23|     237|     259|       7
---------------------------------------------------------------------------
  237-  259 (41.63/18.75)	PELLARSGFQPYR.S.DERLMHPAG
  262-  284 (29.74/11.09)	P.LEAYSHFAGLQ.GiPPAFLNPAG
  289-  310 (23.81/ 7.28)	EQLYLEHRYQLFRaA.GAHPSHP..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.31|      16|      18|      89|     105|       8
---------------------------------------------------------------------------
   89-  105 (27.66/19.79)	QQQHQhQQHQQQQQQQQ
  109-  124 (27.64/14.37)	QQQAQ.QQAVAAAVQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     108.87|      31|     168|     464|     506|       9
---------------------------------------------------------------------------
  464-  485 (36.53/12.52)	.....................HGL..PGM.......................SHYHAAAANAQRQSPH
  491-  558 (30.46/14.32)	NLGMAGlpGVPplgghgpnlqHHLqqAAMglahpgaaglthpgfsaaalglgAHPHSLNLSHPHMSPH
  691-  715 (41.88/11.42)	NGGRAG..GSP..........H.....AM.......................RHHIAAAVAAAAQ...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.61|      14|      70|     854|     872|      20
---------------------------------------------------------------------------
  839-  852 (23.46/18.57)	TAAASGKCKEETPK
  859-  872 (22.15/ 7.70)	TATTKTDIEEEKQR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02300 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GLGAHPHSLNLSHPHMSPHHPASLAHQLPPHTSSAGGGGLSNSIPVTASSSLSASSPHTSLNLTSSVKLSADQVPTSTPSGGVSGSGMPPTTSSSHIPNMGHYYHH
2) HLAAMHAAAAAASGMTPTAAHQQQPLSLPSSPKITPPITPSSSANGGRAGGSPHAMRHHIAAAVAAAAQQSAMIDKAATPVTHEPTTLDLTGSNSNSSNQAPSNASSGQPTNHEVNGAESNGASQTESKEHLAIKEDGHKSSPPPVALEKKPATPNAAADKPIHPDSSPENSSRRSASPQSDANNSLPAVSVTAAASGKCKEETPKILDSDTTATTKTDIEEEKQRARLSVSPTPTAPKIMVASPDTVSTSGGVTSTTSGTTPPPVVSSSTSSAGKAPALTSDEVSTSAATSAAEPTR
3) PSIHAPIPICVPPKAGQKRPATSPAPHIPVPHHLQTPPGGGAGGLPGSSVANSPIPSSAGGNALMNHALPNNHIGTPSPQQQHQHQQHQQQQQQQQHQAQQQAQQQAVAAAVQQQLAAGVGLPPGAIGAASASSRGSFAAALRTLAKQADIKEEDVGGDRSVPTSGAGGPPPSSSGPGSLNSVAGRVGSERPGEDRVSSNKKRSPPSPQPPEKIARLSHTPQTASLQPELLARSGFQPYRSDERL
4) QLFRAAGAHPSHPHAAALYPQMASPYSHLYSMMPGAALGISPAMHDRMKLEEEHRARLAREEEREREIQREKERELREQREKEQREKEQREKEQREREQREKEQREKEARERKLRDEERERERERQQLLTASHHYSNQLYSPLNRNLLGSMIPHLNMSLRGPPGALHGLPGMSHYHAAAANAQRQSPHGAMGLNLGMAGLPGVPPLGGHGPNLQHHLQQAAMGLAHPGAA
540
647
10
298
645
944
254
527










Molecular Recognition Features






MoRF SequenceStartStop




1) KEHLAIKED
2) RHHIAAAVA
3) VALEKK
775
703
792
783
711
797