<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02297

Description Mediator of RNA polymerase II transcription subunit 24
SequenceMSFSLAPFLSPQSWPPPLPPAQSEIMKVVNLKQAILQAWKERWSDYQWAINMKKFFPKGATWDILNLADALLEQAMIGPSPNPLILSYLKYAISSQMVSYSSVLTAISKFDDFSRDLCVQALLDIMDMFCDRLSCHGKAEECIGLCRALLSALHWLLRCTAASAERLREGLEAGTPAAGEKQLAMCLQRLEKTLSSTKNRALLHIAKLEEASSWTAIEHSLLKLGEILANLSNPQLRSQAEQCGTLIRSIPTMLSVHAEQMHKTGFPTVHAVILLEGTMNLTGETQSLVEQLTMVKRMQHIPTPLFVLEIWKACFVGLIESPEGTEELKWTAFTFLKIPQVLVKLKKYSHGDKDFTEDVNCAFEFLLKLTPLLDKADQRCNCDCTNFLLQECGKQGLLSEASVNNLMAKRKADREHAPQQKSGENANIQPNIQLILRAEPTVTNILKTMDADHSKSPEGLLGVLGHMLSGKSLDLLLAAAAATGKLKSFARKFINLNEFTTYGSEESTKPASVRALLFDISFLMLCHVAQTYGSEVILSESRTGAEVPFFETWMQTCMPEEGKILNPDHPCFRPDSTKVESLVALLNNSSEMKLVQMKWHEACLSISAAILEILNAWENGVLAFESIQKITDNIKGKVCSLAVCAVAWLVAHVRMLGLDEREKSLQMIRQLAGPLFSENTLQFYNERVVIMNSILERMCADVLQQTATQIKFPSTGVDTMPYWNLLPPKRPIKEVLTDIFAKVLEKGWVDSRSIHIFDTLLHMGGVYWFCNNLIKELLKETRKEHTLRAVELLYSIFCLDMQQVTLVLLGHILPGLLTDSSKWHSLMDPPGTALAKLAVWCALSSYSSHKGQASTRQKKRHREDIEDYISLFPLDDVQPSKLMRLLSSNEDDANILSSPTDRSMSSSLSASQLHTVNMRDPLNRVLANLFLLISSILGSRTAGPHTQFVQWFMEECVDCLEQGGRGSVLQFMPFTTVSELVKVSAMSSPKVVLAITDLSLPLGRQVAAKAIAAL
Length1014
PositionTail
OrganismHomo sapiens (Human)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hominidae> Homo.
Aromaticity0.07
Grand average of hydropathy0.006
Instability index49.92
Isoelectric point6.44
Molecular weight113011.19
Publications
PubMed=11181995
PubMed=16625196
PubMed=18691976
PubMed=18669648
PubMed=19413330
PubMed=19369195
PubMed=19690332
PubMed=20068231
PubMed=21406692
PubMed=23186163

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
ubiquitin ligase complex	GO:0000151	IEA:Ensembl

GO - Biological Function
histone acetyltransferase activity	GO:0004402	IEA:Ensembl
protein-containing complex binding	GO:0044877	IEA:Ensembl
transcription coactivator activity	GO:0003713	IEA:Ensembl
ubiquitin protein ligase activity	GO:0061630	IEA:Ensembl

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02297
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.27|      27|      29|     325|     352|       1
---------------------------------------------------------------------------
  325-  352 (41.67/33.84)	TEELKwTAFTF.LKIPQVLVKLKKYSHGD
  356-  383 (45.59/30.31)	TEDVN.CAFEFlLKLTPLLDKADQRCNCD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     105.47|      32|      68|     506|     541|       2
---------------------------------------------------------------------------
  507-  541 (51.78/32.83)	STKPASVRALLFDISFLMLChvaQTYGSEVILSES
  576-  607 (53.70/31.82)	STKVESLVALLNNSSEMKLV...QMKWHEACLSIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     181.20|      58|      68|     117|     183|       3
---------------------------------------------------------------------------
  117-  175 (96.99/79.42)	LCVQALLDIMDMFCDRLSCH.GKAEECIGLcRALLSALHWLLRCTAA.SAERLR.EGLEAGT
  185-  245 (84.22/48.62)	MCLQRLEKTLSSTKNRALLHiAKLEEASSW.TAIEHSLLKLGEILANlSNPQLRsQAEQCGT
---------------------------------------------------------------------------











Associated diseases
Disease


























Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02297 with Med24 domain of Kingdom Metazoa
Unable to open file!