| Description | Mediator of RNA polymerase II transcription subunit 11 (Fragment) |
| Sequence | MASPNDLIMSQDGQSQQSRVSEPFTIEENIHQLNAIDKSIAQLMSQTATALNALTTQAPNTSAPNGEASSLDPPAQKEAFKSATDSFLTTLHSIDVRMKRQIMALEEAGIVRLSNTPRQDPNGATKGSLKPNGVGTVGNLDVGWLNSRSTRVERDMEAELWQDAKEFLQKQQNGTGS |
| Length | 177 |
| Position | Head |
| Organism | Metarhizium majus (strain ARSEF 297) |
| Kingdom | Fungi |
| Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Clavicipitaceae> Metarhizium> Metarhizium majus. |
| Aromaticity | 0.03 |
| Grand average of hydropathy | -0.626 |
| Instability index | 53.04 |
| Isoelectric point | 5.04 |
| Molecular weight | 19167.06 |
| Publications | PubMed=25368161 |
| Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364147 |
| GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
| GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
| GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
| Binary Interactions |
| Repeats |
>MDP02291
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 120.13| 40| 56| 33| 73| 1
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33- 72 (66.09/39.37) LNAID....KSIAQLMSQTATALNALTTQAPNTSA.....PN..GEASSLD
91- 141 (54.04/26.73) LHSIDvrmkRQIMALEEAGIVRLSNTPRQDPNGATkgslkPNgvGTVGNLD
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|
| MoRF Sequence | Start | Stop |
| 1) MASPNDLIMSQ 2) RDMEAELWQDAKEFLQKQ | 1 154 | 11 171 |
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Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab