<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02290

Description Mediator of RNA polymerase II transcription subunit 12 (Fragment)
SequenceMGVQPRQPQRGLGSTLHVQRPSNHHQRSISSSQQQYLPTSPVRRDASAALDSSAEPAEAMSGRHVSTPRRQGSKLRLELSNELISAGPISATESPQTLTPSRMMPIPDPMETDNMSPALSRVSQQDSDNPPMPMPRRRLPQTSQAIPSTRPAAPTPASTKKDVRPKPYTVEVPAAAPRYVNTNRHETIGRDPFSKGLFSGNADFFPWSGNHHEDEWSTEAIQKGTWDRGSQNEASSARIAIFPALKQRSGLNALSTLFMGVLNQRRIRGQITVPSTFKPPPRVTLTDTKREIWLKDLANPAISLRRLSRTIPHGIRGRTLLDQCLNKDVPTERAVWLAKCVGANEIRAFKRKGASGAFVLGGELKWIRDWTVFVEQFIESVVSVFGEPDWKSKVTYAIRLATCLYSEQLLDRDHYLEWIISGLENSPQSRIPMWILIGQIYWNDLLQSRKCGRRLVFALLKHLNTIENDPDRDILIQLSSQLSTLVIYLLKTNPESFVCPPAWQRLGETLRLVLPTEDAAAQAAYNTVKLRNTRLLVANTTSPPSGRQYLVQLLDSTLQGKCDPGLSARCWASADDKAGILRTAVEWATSLHRPGLAKVYVVAGLIKSWGAHRINATSTILDALGDIPPGDQMRKRLIIRLVGELVRSGHFSVAQYMQWLIGRGGLHGAEEIDPVDGPCPSRLLVELPIHCLLEEQKAQRGSLLRRAGHYSVGDEANDISSALQYVDSSLGLATYLNGSGPFRRPLSLKKLSRKVRNSSWAVQSAIGAHLYDVITSLPPHRPDFVMALAMFSSVRTMMETVEDYSMLSGILRACSTGPDVDTLAACVDTIDAQLDIFMAIGAAGTLFDIFIERLKAMSRDQGIVVRSLLASLASLAARLPQREDLAKQLSQELAQNDRSNAIDACSPVSDSMATQAQTAEGEVSEQIDKLLASGNVIDHPTMNRLFRYVIIKLESGWGKLDDSRRVFSSLLSRLRMLDALHFDKLMADWISHIRTLKERPPLPELFPLLVSFGCLSMSTILHTANAGSVALDITPDTATSKTATYLQELLQLIIMKLPATQLLDAEETYRFQIYQQRAKFEHAKGLLALIRNSLVEYSALQMPGRTAMLPLDDVACQNFLLETMRFMVVADSAIVAEVLNMSTLPPGATSLAHRIVTRLLLPEADSDHHPSFDHILSLANELTMPFCQLKLNLDLSVNLPSISAIEGETPSRFEAFAKAMDKAIESQNIIWTRMLPCLSDDITQSLNTEAHSRFLDLMPSSKSESLASDTTDEDRIRLAENLLGVIEAIISGQPPSRSASLTNNLVDKLSDMWEIVTSRDEDRAMAKKEVLGHWLPTLLRFITLHSISSEPAHIATAGPGSSAKTAATPNHEVRARIILLLCGLLLEMETLPKELTGSLAQQIFDIAILLVDALPDDLRTQCAKSILFLPGTTASAGTTSDPRLYYLFSTPRPTPAENLKLVHRDKSSVPYTAAARGMGAMYGIGPTLNERLSPFVLRRWEILSEPTPNVGENDTSLSLRLFEAIKIQ
Length1528
PositionKinase
OrganismMetarhizium majus (strain ARSEF 297)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Clavicipitaceae> Metarhizium> Metarhizium majus.
Aromaticity0.06
Grand average of hydropathy-0.172
Instability index46.62
Isoelectric point7.82
Molecular weight168813.71
Publications
PubMed=25368161

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02290
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     831.37|     284|     328|     777|    1104|       1
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  777- 1104 (407.72/365.28)	LPphRPDFVMALAMFSSVRTMMetVEDYSMLSGILRACSTGPDVDTLAACVDTidaQLDIFMAIGAAGTLFDIFIE..........RLKaMSRDQGIVvrslLASLASLAARLPQR.EDLAKQLSQEL.AQNDRSNAIDACspVSDSMaTQAQTAEGEvSEQIDKL.......LASgnviDHPTMNRlfryviIKL.ESGWGKLD.......DSRRvfSSLLSRLrmldalhFDKLMADW.....ISHIRTLKERPPLPELFPLLVSFGCL.SMST.ILHTANAGsvalditPDTATSKTATYLQELLQLIIMkLPATQLLDAeETYRFQIYQQRAK..FEHAKGLLALIRNSL...VEYSALQMPG
 1109- 1431 (423.65/271.82)	LP..LDDVACQNFLLETMRFMV..VADSAIVAEVLNMSTLPPGATSLAHRIVT...RLLLPEADSDHHPSFDHILSlaneltmpfcQLK.LNLDLSVN....LPSISAIEGETPSRfEAFAKAMDKAIeSQNIIWTRMLPC..LSDDI.TQSLNTEAH.SRFLDLMpssksesLAS....DTTDEDR......IRLaENLLGVIEaiisgqpPSRS..ASLTNNL.......VDKLSDMWeivtsRDEDRAMAKKEVLGHWLPTLLRFITLhSISSePAHIATAG.......PGSSAKTAATPNHEVRARIIL.LLCGLLLEM.ETLPKELTGSLAQqiFDIAILLVDALPDDLrtqCAKSILFLPG
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.48|      11|      57|     643|     653|       2
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  643-  653 (21.47/11.71)	GELV.RSGHFSV
  701-  712 (17.01/ 7.84)	GSLLrRAGHYSV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     238.81|      78|     184|       6|      98|       4
---------------------------------------------------------------------------
    6-   98 (116.11/96.90)	RQP.QRGL..GSTLHVQRPSNHHQRSISSSQQQylptspvrrdaSAALDSSAEpAEAMSGRHVSTP...RRQG....SKLRLELSNELISAGPISAtesPQTL
  190-  277 (122.70/70.89)	RDPfSKGLfsGNADFFPWSGNHHEDEWSTEAIQ...........KGTWDRGSQ.NEASSARIAIFPalkQRSGlnalSTLFMGVLNQRRIRGQITV...PSTF
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.69|      16|    1297|     154|     169|       7
---------------------------------------------------------------------------
  154-  169 (33.09/20.60)	PTPASTKKDV.RPK...PYT
 1453- 1472 (22.60/11.62)	PTPAENLKLVhRDKssvPYT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.25|      16|     167|     125|     142|       9
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  125-  142 (27.93/19.33)	QDSDNPPMPMprRRLPQT
  295-  310 (27.32/12.22)	KDLANPAISL..RRLSRT
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02290 with Med12 domain of Kingdom Fungi
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