<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02287

Description Mediator of RNA polymerase II transcription subunit 13 (Fragment)
SequenceMDAAEYDTNILVVNNIASISFRVYEPSSDQSSSFGLAAIDIENSLREKGHIVYYDASRRGIWHFRIVGKEGSDEVSSQELDSSLSLRGYSLIVGEEGSFEPSSLPRPRSQQPQTGHTPTSSTSSASALDQSQRYAPTATSHLGPPGLQEQDSKGHTSVTDAKLVQGGSSSPKAYESFVVATLLTIQSAFCRHTDSIPLNYRTVLLSQNILENDGSFDVVTEKTPTIGTFSAYLTTTGVLVVCMGISICRGLLSYGDMLNQAPDLPGQQILAAPFGVIASNQPAAQFDGTASMAQTPNTQALSLRGAPDIHNSFWKQACLKFLQLRGVAQSKLTDCFWINLLISKPKLQDAKSDVKRSPMPNSTVTIPWPSPLCFRKRPVEVSSTSRVGETILRGHEESHDPLGNAQSWFSSTPERDEKISKRKAERVATSSEGFGGDSRPTRLNGQSPLTLRRPSTAAAGSMYPTPPDALQNANGVTPSLDGTLSSPGNPLSAAAVPEGDNNGSVSMAMGDSFEPVRDFSEPKRQRSDSNLLGEADHMFGDMGQDMFGDNDITEADFNFFDEEPEDIDLEAALDEMGDATTAAIIGAEEHIADEEISNSREPIKEEPEAEKDAGGFTKPELRHAISAQNDHAMPRGRESRPVSMKRESSPFDPHTVFKRVCASLAATEKDGTIATDTNRMTKIFEKMDFDPTLPMINKKYEQGGQFDYSMSTAVGNSRLDHGVLPETDYLKRHGKLHRGSQEHKLYTKSLMGPLSGLEQPNSGRSPTKLDTQMSDDEQSSTESDQDDSSYTSDEPTSPPKSSVKQAPVEEDAVSQVTSLKEQDVIEEPDHQLAIELPRLSKPETPELPLSMLFLDPEPLALELSLGDEDLIQTAQILTEQAATGSLDLCCNTDHPPNSSILSQGRATLLSNARTARQQLREALSVFLRGAEPVRLKAFLDIQDVLLQGQPRMQPRPIPGRDANAEQIRPSNLYQIPGPHLEVRRSDAKLSVLPSAVAFWESLGLAPSSGSKDITAVCVFPGWKGMADNAKTFLGRIKSVYEVLRLGSFENMALASDMGSGVLPYEMDRISTSPDATLTGHGSALIGTMETLRASLSNLTVSDTNVVVYFVYSPNNPGTIVEACAAFQRFFDSYQKDLAAKKETATNELVLQLVSSDLLSSPTSVVVTPSVDLVRLCMETYDRCTLFGGPMPAPAIRLEQPLPRIIDFKLSTQPSVSLIRENSCIHVAYAQTVDGRWVTTAWTDDRGNQQATASYCLGRKGRPLSTSMSEVAHEIWQSTLDLISAWTVHWRVIITKCGPMDQQEIDSWVNLAHTETRLQVTMILMTVDTDPWLQLVPPVVKLPHLSAPFYTTPVSTPQANIVSPEQSATPATPANVTAATPGGGEAGADTETDAILADVTDQTWGAIVGHRLNNSLGVTDLYPALVSGFLIKRTGARAEDVPIAMEVNLIHTEAFPRSYEPLLREMLSYFRGLATLSRARGMVSRETDVRPWHIAAAEKAARAMYLLM
Length1507
PositionKinase
OrganismMetarhizium majus (strain ARSEF 297)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Clavicipitaceae> Metarhizium> Metarhizium majus.
Aromaticity0.06
Grand average of hydropathy-0.361
Instability index51.34
Isoelectric point4.99
Molecular weight163985.08
Publications
PubMed=25368161

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02287
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.80|      16|      20|     299|     314|       2
---------------------------------------------------------------------------
  299-  314 (30.73/17.88)	QALSLRGAPD..IHNSFW
  320-  337 (26.07/14.11)	KFLQLRGVAQskLTDCFW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.47|      18|      18|     762|     779|       4
---------------------------------------------------------------------------
  762-  779 (31.19/15.95)	SGRSPTKLDTQMSDDEQS
  780-  797 (25.27/11.54)	STESDQDDSSYTSDEPTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.26|      13|      22|     519|     539|       6
---------------------------------------------------------------------------
  519-  539 (17.58/29.02)	FSEpkrqrsdsNLLGEAD.HMF
  547-  560 (20.68/10.93)	FGD........NDITEADfNFF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.03|      15|      22|     102|     120|       7
---------------------------------------------------------------------------
  102-  120 (22.91/23.97)	SSLPRPRSQQPqtghTPTS
  126-  140 (26.12/14.42)	SALDQSQRYAP....TATS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.88|      19|      22|    1040|    1059|       8
---------------------------------------------------------------------------
 1040- 1059 (28.66/21.01)	YEVLRLGSFENMALaSDMGS
 1064- 1082 (34.22/20.73)	YEMDRISTSPDATL.TGHGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.79|      18|      22|     949|     970|       9
---------------------------------------------------------------------------
  462-  479 (34.13/13.36)	MYPTP.PDALQNANGVTPS
  952-  970 (30.65/23.41)	MQPRPiPGRDANAEQIRPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.22|      13|      19|     259|     271|      12
---------------------------------------------------------------------------
  259-  271 (23.70/13.99)	NQ.APDLPGQQILA
  280-  293 (18.52/ 9.09)	NQpAAQFDGTASMA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.54|      14|      19|     832|     849|      13
---------------------------------------------------------------------------
  832-  849 (18.24/16.65)	LAIELprlsKPETPELPL
  852-  865 (23.30/10.38)	LFLDP....EPLALELSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.70|      15|      21|     869|     888|      15
---------------------------------------------------------------------------
  869-  883 (23.74/23.42)	DLIQTAQILTEQAAT
  893-  907 (26.96/11.75)	DHPPNSSILSQGRAT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02287 with Med13 domain of Kingdom Fungi
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