<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02285

Description Mediator of RNA polymerase II transcription subunit 14 (Fragment)
SequenceMESSGHNGTRTDHDRDSSMNGVNGANGTPQDSGFPKEKASAATATDGSAKAINGNDESRSQETNQNGEAERVISRMNDLPDEIVHITQGFVPLSLLLTRLAQTSHNALQDKVAEMAKMPLPAAAANGSSSYSSSGPDDSSADNLRKKGALTNFAQEWHGKWLKALVIAEWSRKAHLVSKLIDLKFHIDQQRILYDAALDEMVNVKRDLTFARMPSPDLKTALQVLSTGNAPWMPDLGYLEPPTLTPEVQLKWINELNTLLSLRLNLDDFDKIPYHFRNYEISSGRVTFKVEGEFEVDLTIADEDFEKQFWFIDFRYAFTPAASSISESLRNYLENCVNDVLGKEGLLGCYQFLHELVLTTKIHELKRQAMQLSRTSWTGTLNVEPLNRALSIQYWTGRSTTMGSKSWIIVAVNSNRPRNGKEAASSTSQLVVNWYRDNKEVKDVEIEFNVNELSAEALLTNVIARHIEHILTSIHDKLLTVARFKNHEASMALRVSRTDPAFSSLTTQVGHSGEASMLLEPMTGVFALKPPSRFTIQPEHQLNMGKNPAEDGLNCLEVLRCAVMEDELHCWATLMGWFVRKPPMAAEELKSAIKVRDWTRVICLQKDGWGSNWFVVVVLSLNGDEWWLLESNPNEASKTLRFKAKLPFNNGYPDLSDVFWENLAFFTTGVIAQSVDLRELHRQKIKSRSSNRISLSTSQTVRLPSTDVALSALFPSMVFDQSKPEEDALSNSEGQLSNLELLSLIQQASGAVLVRKKAWADNIVSITFRGIRCLSKAENADDGSKENELICTSEAILKVRKPSKFASLDGLADRDVSYNPKRGEFALRIQRAVGRPILDTLKSRIKAIDRFVNFLEALESANGTITTESVTLRQITFYYSELQTKQSSNDADQVMEDSRKRWRVVLDLSKDDIDIEIEKGNPHLRVLDLMRQLVNSDGGIGVLTAWLPASLPALQAIDKMETEWEPIQAGGQGRIEFSMKTVAWMSVEYTMASEAKTLKNPIRLQVQMQPRRSQAWWHVWRSDAEPNADDRVSTALQPIWNKRGDNWFGLSTGAAGRPQDGVVKMLLAVDEAIRSTITSGPGVTQGNEVVVLD
Length1093
PositionTail
OrganismMetarhizium majus (strain ARSEF 297)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Clavicipitaceae> Metarhizium> Metarhizium majus.
Aromaticity0.07
Grand average of hydropathy-0.363
Instability index39.12
Isoelectric point5.77
Molecular weight122182.90
Publications
PubMed=25368161

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP02285
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.45|      27|      29|    1008|    1036|       1
---------------------------------------------------------------------------
 1009- 1035 (51.49/27.11)	QP...RRSQAWWHVWRSDAEPNADDRVSTA
 1037- 1066 (43.96/21.38)	QPiwnKRGDNWFGLSTGAAGRPQDGVVKML
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.51|      26|      35|     248|     276|       7
---------------------------------------------------------------------------
  248-  276 (37.59/34.61)	VQLKWINELNtlLSLRLNLDDFDKiPYHF
  286-  311 (45.92/29.98)	VTFKVEGEFE..VDLTIADEDFEK.QFWF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.26|      17|      18|     443|     460|       8
---------------------------------------------------------------------------
  443-  460 (22.55/18.41)	DV...EIEFNVNELSaEALLT
  461-  480 (23.71/14.21)	NViarHIEHILTSIH.DKLLT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.82|      20|      29|     922|     941|       9
---------------------------------------------------------------------------
  922-  941 (35.76/23.19)	PHLRVLDLMRQLVN..SDGGIG
  952-  973 (32.06/20.03)	PALQAIDKMETEWEpiQAGGQG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02285 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MESSGHNGTRTDHDRDSSMNGVNGANGTPQDSGFPKEKASAATATDGSAKAINGNDESRSQETNQNGEAERVISRMND
1
78










Molecular Recognition Features






MoRF SequenceStartStop




1) GFPKEKASAA
33
42