<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02276

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDVAEYDTNVFVVNNIASISFRVYEPSSDQSSSFGLVAVEIEKFLREKGHVVYYDASKRGIWHFRIVGKEGNDEVSSQELDSSLSLRGYSLNVGEEGYFEPSSLPRARSQQPQAGHTPTSSTSSAPALDQSQRHAPAVTSHLGLPGLQEQDSKGNTSVLDAKSVQGGPSPTKAYESFIIAALSTIQSAFCSRTDSIPLNYRTVLLSQYTLGNCGSFDLVQGKFPTIGTFSAYLTTTGVLVVCINISVRQGLLSYSDSPPGLLGQQILAAPFGMIASNQSGAQFDGGTASMVQTPNTQAALSLRGAPDIHNSLWKQACLKFLQLRGVAQSKFTDCFWMNLLISGPKLQDAKNDVKRLSVPNSTVTIPWPSPLCFRKRPVEVSSTSRVGETILRGHEESHDPLGNAQFWFSSTSERDEKISKRKAERAAVPSEGFSSDSRPTRPNGQSPLTLRRLSTAAAGSVYPTPPDALQNAPGVTPSLDGTLSSPGNPLSAAALPEADNNGSVSVTIGASFEPGRDLSETKRQRSDSNLLGEAEHMFGDMGEDMFGDNDITEADFNFFDEEPGSVDLEATFADMGAATTDEIIATEDHAADEEMRNAKDPVEEEQEVEKDNGGFTKPELRHAISVRNDNATSRGRDSRPVSMKRESSPFDPHTVFKRVRASLATTEKNDSLAKNTNRMTKIFEKMDFDPALPMINKKYEQGGQYDYRKSTIAGSSRLDLGLFPETDCLRRFAKAPRGFRDQRSYAGSLMGPLPGLEPPLSGRSPTKLDTQISDDEQSSTESDQDDSSYTSDEPTSPLKSSIKQAPAEDDVASQVTSTKEQDMMEEPDHQLAAELPRLAKPETPELPLSKLFSDPEPLALELALGDEDLIQVAQILTEQAATGSLDLCNMDCPANTSIVSRSQASSLGDARTAIQQLGDALPLFLRGVEPVRLKAFLDIQDVLLQGQPRMQPRPMPGRDANAEQMRPSNLYQIPGPHLEVRRSEAKLSVLPSAVAFWESLGLAPSSGNKDITAVCVFPGWKGMADNAKTFLGRVKSVYEVLRLGSFENMTLAPDMDAGLLPYEVDRISTSPDATLTGHGSALIGSMETLRGSLSSLTVSDTNVVVYFVYSPNNPGTIVEACAAFQRFFDSYQMDLAAKKETAANELVLQLVSSDLLSSPTSVVVTPSVDLARLCMETYDRCTLFGGPMPAPAIRLEQPLPRIIDFKLNTQPSVSLIRENSCIHVAYAQTVDGRWVTSAWTDDRGNQQATASYCLGRKGRPLSTPMDKVAHEIWESTLDLISAWKVHWRIIITKCGPMDQQEIDFWVDLARTEIKLPVTMILMTADTDPWLQLVPPVVRLPQPSVPFYTTPVSTPQANIVSPEQSATPATPGGGEAGADSETDAVLADVTDQTWGAIVGHRLNNSSGVTDLCPALVSGFLIKRTGARAEDVPVAMEVNLIHTEALPRSYEPLLREMLSYFRGLATLSRARGMVPREMDVRPWHVAAAEKAARAMYLLM
Length1497
PositionKinase
OrganismMetarhizium album (strain ARSEF 1941)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Clavicipitaceae> Metarhizium.
Aromaticity0.07
Grand average of hydropathy-0.340
Instability index49.99
Isoelectric point4.98
Molecular weight162765.06
Publications
PubMed=25368161

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02276
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.15|      21|      25|     481|     501|       1
---------------------------------------------------------------------------
  481-  501 (36.42/18.39)	GTLSSPGNPLSAAALPEADNN
  509-  529 (36.73/18.61)	GASFEPGRDLSETKRQRSDSN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.12|      13|      16|     116|     128|       3
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  116-  128 (23.13/12.03)	HTP.TSSTSSAPAL
  134-  147 (19.99/ 9.36)	HAPaVTSHLGLPGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.76|      20|      23|    1038|    1059|       4
---------------------------------------------------------------------------
 1038- 1057 (35.67/24.48)	YEVLRLGSFENMTLAPDMDA
 1062- 1081 (35.10/16.95)	YEVDRISTSPDATLTGHGSA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.48|      14|      23|    1303|    1316|       5
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 1303- 1316 (25.90/14.43)	DFWVDLARTEIKLP
 1327- 1340 (27.58/15.84)	DPWLQLVPPVVRLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.03|      12|      23|      67|      84|       6
---------------------------------------------------------------------------
   67-   84 (16.19/23.68)	VGKEGNDEvssqelDSSL
   93-  104 (23.85/15.10)	VGEEGYFE......PSSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.14|      17|      21|     297|     313|       7
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  297-  313 (31.70/17.29)	QAA...LSLRGAPD..IHNSLW
  315-  336 (24.45/11.78)	QAClkfLQLRGVAQskFTDCFW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.76|      23|      29|     419|     447|       8
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  419-  447 (35.35/32.01)	SKRKAERAAVPSegfssdSRPTRPN......GQSP
  449-  477 (35.41/18.46)	TLRRLSTAAAGS......VYPTPPDalqnapGVTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.47|      28|      32|     693|     724|       9
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  693-  724 (42.61/36.75)	PMINKKYEqgGQYDYRksTIAGSSRLDL.GLFP
  730-  758 (47.86/28.09)	RRFAKAPR..GFRDQR..SYAGSLMGPLpGLEP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.46|      19|      21|     190|     208|      10
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  190-  208 (33.86/17.08)	CSRTDSIPLNYRTV.LLSQY
  213-  232 (30.60/14.82)	CGSFDLVQGKFPTIgTFSAY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.46|      23|      24|     546|     569|      11
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  546-  569 (35.58/22.78)	FGDNDITEADfNFFDEEPGSVDLE
  572-  594 (37.88/19.72)	FADMGAATTD.EIIATEDHAADEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.84|      13|      16|     792|     804|      13
---------------------------------------------------------------------------
  792-  804 (22.18/13.33)	DEPTSPLKSSIKQ
  809-  821 (19.67/10.87)	DDVASQVTSTKEQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.43|      27|     588|     338|     381|      15
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  341-  369 (39.83/38.16)	ISGPKLQDAKNDVKrLSVPNSTVTIpWPS
  973-  999 (47.60/16.20)	IPGPHLEVRRSEAK.LSVLPSAVAF.WES
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.99|      10|      25|     381|     390|      23
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  381-  390 (17.49/10.35)	SSTSRVGETI
  409-  418 (17.50/10.36)	SSTSERDEKI
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02276 with Med13 domain of Kingdom Fungi
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