<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02275

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMTSPDGPPLSLRPFPVADRAPKNLAEFIARVNAQPGGFRDVTEAKLQDEIKSGEVVSGGDSDQDEVDVSDPGRDEDPVKDAAVVRMEVLRNIEIAGNTAMLTLDSLSLLLSKQSPTQAGLTLSQQLREMVGIGTLGADKLDEPILNPDKERDEEEVATGWTLMQINQARDAADEAGRFLQREVEAESKYWEDVMAVKKAGWSICRVPHERHTLGVKFGFSEASPEFKSNGLAPMRRGDSGSVELDLGRLGGVSEGLVVTYEQDGKVVGRSVPRRRRHDDTSLESRILEARNTIFSQELWHELTREARTLAAYDVRPEGSTLTCSVDSRSKIILELLPLESCPASDGSLPNNSVAETIFISLHVLLSYAHRYNELMRIRPIPPHISRSRGQQVYALLRPVIARMASNRAILSCTTYLGSVSKALQKAGLPASLTLRTAQLSAADHSAQGPNQPAGAQSLIRNMLQPVEFNVALAILPDTSLTVRGRTFLFPVTTTFYHVALAPSSPLRDTCAPYAEGYSDTNALFSYIRTATERAVTLHFFQSLCAAPDPVPWIHSGTSIRDPEDDARVLQFSIDEHPVALVLTSSFAGSPNRGPESWTYSYSDSAHLDSEPQNLDDLVARETSRSRP
Length627
PositionHead
OrganismMetarhizium album (strain ARSEF 1941)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Clavicipitaceae> Metarhizium.
Aromaticity0.06
Grand average of hydropathy-0.334
Instability index53.56
Isoelectric point5.26
Molecular weight68663.36
Publications
PubMed=25368161

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02275
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.34|      15|      16|     223|     237|       1
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  223-  237 (27.08/16.10)	SPEFKSNGLAPMRRG
  241-  255 (24.25/13.69)	SVELDLGRLGGVSEG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.34|      15|      21|     171|     186|       2
---------------------------------------------------------------------------
  171-  186 (20.51/14.68)	AADEAGRFLQReVEAE
  195-  209 (28.83/16.47)	AVKKAGWSICR.VPHE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.48|      17|      20|     362|     380|       3
---------------------------------------------------------------------------
  362-  380 (26.01/24.45)	HVLLSYAHRYNELMriRPI
  383-  399 (29.47/19.95)	HISRSRGQQVYALL..RPV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.65|      19|      25|     460|     480|       4
---------------------------------------------------------------------------
  460-  480 (30.44/23.92)	RNMLQPVE...FNVALAilPDTSL
  485-  506 (31.21/18.19)	RTFLFPVTttfYHVALA..PSSPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.01|      12|      20|     277|     289|       5
---------------------------------------------------------------------------
  277-  289 (16.65/11.04)	HDDTSlESRILEA
  300-  311 (20.36/ 9.43)	HELTR.EARTLAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.83|      18|      20|     413|     430|       6
---------------------------------------------------------------------------
  413-  430 (28.78/16.36)	TTYLGSVSKALQKAGLPA
  436-  453 (29.05/16.57)	TAQLSAADHSAQGPNQPA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     165.96|      54|     488|      20|      78|       9
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   20-   78 (82.57/67.31)	APknLAEFIARVNAQPGGFRDVTEAKLQDE..............IKSGEVVSggdSDQDEVDVSDPGRDEDPV
  511-  578 (83.39/53.33)	AP..YAEGYSDTNALFSYIRTATERAVTLHffqslcaapdpvpwIHSGTSIR...DPEDDARVLQFSIDEHPV
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02275 with Med17 domain of Kingdom Fungi
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