<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02271

Description "Mediator complex, subunit Med12"
SequenceMGVQPRQPQRGLSSTLQVQRPPNHHQRSISSSQQQYLPTSPARRDASAAFEPSTEPAEIMLGRHVSTPRRQGSKLRLELSNELISTAPLSATESPQTLTPSRMVPLPDPMETDTTSPALSHQDGDNPPMPMPKRRLPQTSQAVPFTRPAAPTPTLAKKDVRPKPYTVEVPAAAPRYVNTNRHETSGRDPFSKGLFSGHADFFPWSGNHHEDEWSTEAIQKGTWDRGSQNEASSARIAIFPSLKQKSGLNALSTIFMGVLNQRRIRGQITAPSTFKPPPRVTLTDTKREIWLKDLANPAISLRRLSRTIPHGIRGRTLLDQCLNKDVPTERAVWLAKCVGANEIRAFKRKGASGAFVLGGELKWIRDWTVFVEQFIESVVSAFGEPDWKPKVTYAIRLATCLYSEQLLDRDHYLEWIISGLENSPQSRIPMWMLIGQIYWNDLLHSRKCGRRLVFALLNHLNTIEHDPDRDILVQLSSQLSTLIISLIKTNPESFVCPPAWQRFCETLRLALPADDAVAEAAYNTIKLRNTRLVVANTTSPPSGRQYLVQLLDSTLQGQCSPGLSARCWASADEKTGVLRTVVEWATSLHRPGLAKVYVAAGLIESWGAHRINATSTILDALGDMAPGDKIRKKLTIRLVGELVRAGHFSVPQYMQWLIGRGGLHGADEIDPVDGPCPSRLLVELPIHCLVEEQKAQRGSLLRRAGHYSVVDEATDISSALQYVDSFLGLSTYLNGPQPCRRPLSLKKLSRRIEDSSWAVQSTIGSHLHDVVTCLLPPRPHFVMTLAMLGSIRTIMETVEDFSMLSRILKTCSTDPDVDILAACVDTINAHLDIFMAIGTAETLFDHFIERLKVMSRDQGIVVRSLLASLASLAARLPQREDLAKQLSRELAQNDRSNAIDACSPISDSMATQAQTAEDEVSEQIDKLLASGNVIDHPTMNRLFRYVIVKLESGWGKLDDSRRVFSSLLSRLRMLDALHFDKLMADWVSHIRTLKERPPLPELFPLLVTFGCLSMSTILHTANASSVNLDATRDIVTSKTATYLQELLQLMVVKLPVTALLDAEETYRFQIYQQCAKFEHGKGLLALIRNSLVEYSALRMASQATMLPLDDVNCQDCLLETMRFLVVADSAIVAEVLNMSTLPPGATSLAHRLVTRLLLPEADSDHHPSFERILSLANELTMPFCQLKLNLDLSMNLPNTPDAQSEAPSRFEAFAKAMDQAIESHNIIWTSMLPCLSDDITQSLNREAHTRFLDLMPSSKSESFASETTDENRIHLAENLLGVIEAIISGQPPSRSASLTNSLVDKLSDMWEIVASRDEDRALAKKEVLERWLPTLLRFITLHSISLEPSNTAAAGPSSSAKPATSTHNHEARARIILVLCGLLLEMETLPQELARSLVQQIFDISILLVDALPDDLRTQCAKSILFLPGTTASTATTSDPRLYYLFSAPRPTPAENLKLAHREKSSMPYTAAARGMGAMYGIGPASNERLSPFVLRRWEILSEPTPNVGENDTSLSLRLFEAIKVQ
Length1526
PositionKinase
OrganismMetarhizium album (strain ARSEF 1941)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Clavicipitaceae> Metarhizium.
Aromaticity0.06
Grand average of hydropathy-0.190
Instability index46.52
Isoelectric point6.81
Molecular weight169350.19
Publications
PubMed=25368161

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02271
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.09|      30|      60|     640|     679|       1
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  640-  676 (55.44/60.70)	GELV.RAGHFSVP..........QYMQWLIGRGG.LHGADeidpvdgPC
  698-  739 (41.66/22.12)	GSLLrRAGHYSVVdeatdissalQYVDSFLGLSTyLNGPQ.......PC
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     169.99|      53|      60|      54|     111|       2
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   54-  111 (79.54/55.82)	TEPAeiMLGRHVSTPRRQGSKLRLELSNELIS.TAPlsATESPqTLTPSRMVPLPDPME
  115-  168 (90.45/48.56)	TSPA..LSHQDGDNPPMPMPKRRLPQTSQAVPfTRP..AAPTP.TLAKKDVRPKPYTVE
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     136.89|      53|     441|     299|     470|       3
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  299-  344 (57.98/205.79)	ISLRRLSRTIPHGIR......GRTLLD..QCLNKdvPTERAVWLAKCVGAneIR..............................................................................................................................
  460-  470 ( 0.90/42.57)	......................................................afkrkgasgafvlggelkwirdwtvfveqfiesvvsafgepdwkpkvtyairlatclyseqlldrdhylewiisglenspqsripmwmligqiywndllhsrkcgrrlvfallnhLNTIEHDPDRD
  743-  818 (78.00/ 0.00)	LSLKKLSRRIEDSSWavqstiGSHLHDvvTCLLP..PRPHFVMTLAMLGS..IR....................................................................................................timetvedfsmlsriLKTCSTDPDVD
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.89|      27|     439|     394|     452|       4
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  394-  431 (42.38/85.45)	A.................IRLATclyseqlldrdHYLEWIISGLENSPQSRI..PMW
  455-  500 (30.51/ 6.18)	AllnhlntiehdpdrdilVQLSS...........QLSTLIISLIKTNPESFVcpPAW
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     267.11|      72|     320|     969|    1041|       5
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  583-  624 (52.72/28.04)	................EW..AT...SL....HRPGLAKVY...VAAG.LIESWGAHRINATSTILDALGDM.......
  969- 1041 (118.02/77.79)	SRLRMLDALHFDKLMADW..VS...HIRTLKERPPLPELFPLLVTFGcLSMSTILHTANASSVNLDATRDIVTSKTAT
 1293- 1364 (96.37/57.83)	SRSASLTNSLVDKLSDMWeiVAsrdEDRALAKKEVLERWLPTLLRF......ITLHSISLEPSNTAAAGPSSSAKPAT
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---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.92|      29|     260|    1136|    1164|       7
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 1136- 1164 (50.46/33.82)	LNMSTLPPG.ATSLAHRLV.TRLLLPEADSD
 1384- 1414 (40.46/25.43)	LEMETLPQElARSLVQQIFdISILLVDALPD
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02271 with Med12 domain of Kingdom Fungi
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