<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02270

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMPLILDNSMQVDLNNVDDLFGDNVPLSIPVRPQGKQLRQRLDELRNRGACQTVAWSKSGTIASLTPDGQTLELRFLRCHPDTGVWELSEATTCELVKGSPAIPLVHLEWGPTNTPDLAVIDAAGRVALVSFAISLNHPFINRHWETDMIDDLHGVVGCYWLPLAPGSPSKPFNIMYGPANKNGNVYHYENVFVHIIGPHHPHSSKSAFFCVNSGGMMKMYWPQNNNRWEETTMELESINSSDELVTHAAFASDRKNLLAAIATSSRQLKLLKIEVQWAGPGSSSEKNTMPPNARLNPALVETHVASTSWLCPGPSETNYDASIAELSFLHLLPAIMDSTGSSTAPPLIVTVRSRYVGDGSFQSIQSVLDRWEAFESKQGLDPAFEQLGNRRNSVSSDLANVTRLKKLESVVINKGVIGIQDIQYKRVLIFAMSDGSIEYRDRFTFEELYAHEDLNKVMTMRQVGWTFSDNEPCYQAAFSPTYCSMVQIGDDGKLRWNKLQYPLGDIGNTPQDPHYTATIAALSIAAAFAVWHMSNFDDVLAIARPLTSRTRFVSDFVGDLIRLLKIQVDYSEEMHHDSLMRNSPLQSCLSIMSSLGFRGETHRRTFLSKFSIISLNMRNVVILITLASNTPTNIREKMSPLDEHEVVEALAGCAKWSVDLLCWLIDCLFELMNDDKFKQRLQAKQLGELNQYLHEKNDVSLHLLLSSSSRSFVSALCRRISILENISNKAIDFYKRQASGDQQSGAKPPKPQLQQAYQRMQQVTSTSLIRVAELEKLLNILASDIRQTYASYLPRIVKNQPNPPQGKQLDIAIKNTQAQFEMVTLLSGSLGPSFLPVLIKLFGKELPAFRKLTDPAKLFFADFKLLGLEDDKNSLTARKAKGVHVDIFKRTELRDGGGRSRWRRCTRCTAVMEDVYGSRPGFTFVLAQQRKCSCSGYWALLPKGKEVL
Length948
PositionTail
OrganismMetarhizium album (strain ARSEF 1941)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Clavicipitaceae> Metarhizium.
Aromaticity0.08
Grand average of hydropathy-0.239
Instability index47.61
Isoelectric point7.81
Molecular weight106150.21
Publications
PubMed=25368161

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02270
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     136.72|      32|      54|     221|     252|       1
---------------------------------------------------------------------------
  221-  252 (57.72/33.11)	WPQNNNRWEETTMELESINSSD..........ELV.THAAFAS
  277-  308 (49.56/27.47)	WAGPGSSSEKNTMPPNA.RLNP..........ALVeTHVASTS
  495-  530 (29.44/13.57)	......RWNKLQYPLGDIGNTPqdphytatiaALS.IAAAFAV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     120.53|      36|      54|     650|     685|       2
---------------------------------------------------------------------------
  650-  685 (65.61/47.21)	LAGCAKWSVDLLCWLIDCLFELMND..DKFKQRLQAKQ
  705-  742 (54.92/38.24)	LSSSSRSFVSALCRRISILENISNKaiDFYKRQASGDQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.84|      30|      32|      52|      81|       3
---------------------------------------------------------------------------
   52-   81 (55.12/35.57)	TVAWSKS.GTIASLTPDGQTLELRFLR....CHPD
   82-  116 (40.72/24.32)	TGVWELSeATTCELVKGSPAIPLVHLEwgptNTPD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.13|      14|      54|     748|     761|       5
---------------------------------------------------------------------------
   29-   42 (27.51/17.00)	PVRPQGKQLRQRLD
  748-  761 (27.62/17.10)	PPKPQLQQAYQRMQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.65|      13|     368|       7|      19|       6
---------------------------------------------------------------------------
    7-   19 (23.71/14.39)	NSMQVDLNNVDDL
  392-  404 (21.94/12.82)	NSVSSDLANVTRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     147.61|      45|     456|     418|     473|       7
---------------------------------------------------------------------------
  421-  473 (66.16/66.06)	DIqYKRVlifAMSDGSIEYRDRFTFEELYAHEDlnkVMTMRQvGWTF..SDNEPC
  886-  932 (81.45/46.13)	DI.FKRT...ELRDGGGRSRWRRCTRCTAVMED...VYGSRP.GFTFvlAQQRKC
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02270 with Med16 domain of Kingdom Fungi
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