<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02266

Description "Mediator complex, subunit Med21/Med9"
SequenceMLNNKVSSSPAPPEGHKGAGAVGRIVSPSGRADSAPLQCIWPTCTSRLENRLQVLASRQGFVVPFAIDRNPSGATMGDRLTQLQDAVDQFAQQFVACLHFVQRRHDLETLGPNDKVRDIKQEPHQREVDPLPADELAAGLKELSRDLIIKEQQIEVLISNLPGLDNSERDQERNIKDLEEKLKAAEAQRQEALKERDQILAELDSVIRSIRRP
Length213
PositionMiddle
OrganismMetarhizium album (strain ARSEF 1941)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Clavicipitaceae> Metarhizium.
Aromaticity0.03
Grand average of hydropathy-0.597
Instability index58.82
Isoelectric point5.67
Molecular weight23748.55
Publications
PubMed=25368161

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02266
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.74|      18|      27|     117|     142|       1
---------------------------------------------------------------------------
  117-  142 (22.86/30.77)	RD..IKQEphQREV..DPLPadelaaGLKE
  145-  166 (23.87/11.90)	RDliIKEQ..QIEVliSNLP......GLDN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      86.03|      28|      32|      59|      87|       2
---------------------------------------------------------------------------
   48-   66 (22.46/ 9.35)	.........LENRL.QVLASRQGFVVPFA
   67-   95 (43.78/27.56)	IDRNPSGATMGDRLtQLQDAVDQFAQQFV
  101-  116 (19.79/ 7.58)	VQRRHDLETLGP.....NDKV........
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02266 with Med21 domain of Kingdom Fungi
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