<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02265

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMESSGHNGTRTDHDRDSSMNGVNGANGVVQGAGFPKEKASDAAATDGSARTINGNDESRSLECYRNGDAEKMTNRMNDLPDEIVHITQGFVPLSLLLTRLAQTSHNALQDKIAEMAKMPLPQAAANGTSSFSSSAPDDSSAENLRKKGALTNFAQEWHGKWLKALVITEWSRKAHLVSKLIDLKFHIDQQRILYDAALDEMVNVKRDLAFARMPSPDLKTALQVLSTGSAPWMPDLGYIEPPHLTPEVQLKWVNELNTLLSLRLNLEDFDKIPYHFRNYEIGSGRVTFKVDGEFEVDLTIADEDFEKQFWFIDFRYAFKPAASSIPESLRNHLENCVNDVLGKEGLHGCYQFLHELVLTTKINELKRQATQLSRTSWIGTLNVEPLNRALSIQYWTGRSTTMGSKSWILIAVNSNRSSNSKEDISSTSRLVAKWYRDNKEVKGGEIRFDVNELSAEALLTNVIARHIEHILSSIRDKLFTAARFKSREASMALRVSSTDPAFSSLTTQVGHSGQISMLVEPMTGVFALKPPSRFTMQPEHQLNMGRNPAEDGLNCLEALRCAIMEDELHRRATLMGWRLRKPPMAAEELKLAIRVRDWTRVICLQKDGWASNWVVVVVLSLNGDEWWLLESNPNETNKALRFQAKLPFNNGYPDLSDTFWENLSFLTTGIIAQAVDIRELHRQKIKTRSSHKFDLCLAQTARLPSTDVALSALFPSMVFDQSKADKDGLSNSEGQPGDMGLLSLIQQASGATSVRKKAWADNIVSITFRGIRCLSKAENGHDGTEENELICTSEAILKVRKPSRFASLDGLADRDVSYNPRRREFALRIQRAVGKPILDTLKSRIKAIDRFVNFLEALESASGTITTESVTLRQITFYYSELRTKETKEEEEEEDQVMEDEPQRWRVVLDLSNDDIDIEIEKGNPHLRVLDLMRQLVNSDGGIGVLTAWLPASLPALQAIDKMETEWEPIQAAGQGRIEFSMKTVAWMSVEYTITSDPETLTHPVRLEVKMQPRRSQAWWHVWRSDAKTDAQDGVSTALQRVWNQRGEDWIGLCTGAAGSPQSGVVHMLLAVDEAVRNAISRGAGAAQGNEVVVLE
Length1096
PositionTail
OrganismMetarhizium album (strain ARSEF 1941)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Clavicipitaceae> Metarhizium.
Aromaticity0.07
Grand average of hydropathy-0.392
Instability index41.37
Isoelectric point5.80
Molecular weight122756.51
Publications
PubMed=25368161

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP02265
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     319.11|     102|     110|     845|     953|       1
---------------------------------------------------------------------------
  845-  953 (154.74/132.83)	IKAIDRFVNFLEALESA.SGTITTESVTLRQITFYYSELRTKETKEEEEEEDQVMedEPQRWRVVLDLSNDDIDIEIEKGnphlrVLDLMRQLVNSDG..GIGVLT..AWLPAS
  957- 1063 (164.37/120.57)	LQAIDKMETEWEPIQAAgQGRIEFSMKTVAWMSVEYTITSDPETLTHPVRLEVKM..QPRRSQAWWHVWRSDAKTDAQDG.....VSTALQRVWNQRGedWIGLCTgaAGSPQS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.79|      23|     181|     136|     160|       2
---------------------------------------------------------------------------
  136-  160 (38.24/30.79)	PDDSS.AENLRKKgaLTNFAQEWHGK
  320-  343 (37.55/23.21)	PAASSiPESLRNH..LENCVNDVLGK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.39|      24|     181|     596|     643|       3
---------------------------------------------------------------------------
  395-  422 (33.99/ 6.01)	WTgRSTTM...G.SKSWILIAVnsnRSSNSKE
  598-  625 (34.40/65.22)	WT.RVICLqkdGwASNWVVVVV...LSLNGDE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     191.36|      63|     268|     167|     230|       4
---------------------------------------------------------------------------
  167-  230 (101.12/78.02)	ITEWSRKAHLVsKLIDLKFHIDQ...QRILYDA...ALDEMVNVKRDLAF..ARMPSPDLKTALQVLSTGSA
  431-  501 (90.24/64.46)	VAKWYRDNKEV.KGGEIRFDVNElsaEALLTNViarHIEHILSSIRDKLFtaARFKSREASMALRVSSTDPA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     196.39|      61|     270|     510|     571|       5
---------------------------------------------------------------------------
  510-  571 (106.64/72.55)	GHSG.QISMLVEPMTGVFALKPPSRF.TMQPEHQLNMGRNP..AEDGLNCLEALRCAIMeDELHRR
  780-  844 (89.75/56.31)	GHDGtEENELICTSEAILKVRKPSRFaSLDGLADRDVSYNPrrREFALRIQRAVGKPIL.DTLKSR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     271.90|      85|     678|       9|      94|       6
---------------------------------------------------------------------------
    9-   94 (142.31/100.97)	TRTDHDRDSSMNGVN..GANGVVQGAGFPKEKASDAAA.TDGSARTiNGNDESRSLECYRNGDAEKMTNRMNDLPDEIVHIT.QGFVPLS
  687-  775 (129.59/87.20)	TRSSHKFDLCLAQTArlPSTDVALSALFPSMVFDQSKAdKDGLSNS.EGQPGDMGLLSLIQQASGATSVRKKAWADNIVSITfRGIRCLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.14|       9|      33|     267|     276|       7
---------------------------------------------------------------------------
  267-  276 (15.34/15.61)	EDFDKiPYHF
  303-  311 (19.80/13.87)	EDFEK.QFWF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02265 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MESSGHNGTRTDHDRDSSMNGVNGANGVVQGAGFPKEKASDAAATDGSARTINGNDESRSLECYRNGDAEKMTNRMNDLPD
1
81










Molecular Recognition Features






MoRF SequenceStartStop




NANANA