<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02250

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMYGRMSKSEQQKVGGGEMAQRDMMQRMWKQPQENPVNAYAPPPTIAQSSYMEPMHASTSYPSGMPPSQGPPPPQQKQPPPPHVSSQQQPSVLENLINSPQFGSQPTPSGRPMGGSLNMVSQALVDMPQPQANINAAQHNEQRMYMEKLRSLKAYCEPLRARAQQCRMEGNESAANKFDTMCSVIEGRTRVSFEYLQQVETWIYKKQDFLHAALVSPVSGSSSQAQPQPLVDAVNAVLLNGDTQGGYADRMQPTGPPVAGPSPQWQPAVNTQHSPHAPPSMVSSMGLNPQMQPASTGPPNVPLPHMHSPQLHGGAQGPPIQVHHTMEHSPYQRHSPYPHPPAPMRSSSQHHTQKQQSMQQLPPRMVSSSFGPFTKRRKLPAPPTGIGPPPPTMIEPARGTAMDNGSGVEDLYVMDDFLPTPMEAIPSNTLPQVGAQLPEAARRELMALGDRFTVDPSIEPGPNSNTVIVRCSLNSQPVPPLRLVVPRTYPTGQLSVDRAALDLDSFFFDDLQNVIHERLARPGLGTITDYLETWESTVRNYYMGQQQQTSVPTSFDDIFQTSTFDDILS
Length568
PositionTail
OrganismToxocara canis (Canine roundworm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Spirurina> Ascaridomorpha> Ascaridoidea> Toxocaridae> Toxocara.
Aromaticity0.06
Grand average of hydropathy-0.661
Instability index70.67
Isoelectric point6.28
Molecular weight62381.68
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02250
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     114.65|      34|      36|     395|     428|       2
---------------------------------------------------------------------------
  395-  428 (62.38/32.86)	PARGTAMDNGSGVEDLYVMDDFLPTP.MEAIP.SNT
  430-  465 (52.27/26.42)	PQVGAQLPEAARRELMALGDRFTVDPsIEPGPnSNT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     140.02|      26|      27|      18|      43|       3
---------------------------------------------------------------------------
   20-   46 (42.00/12.27)	QRDMMQRM...WKQPQENPVNAYA.PPPtIA
   47-   73 (37.03/ 9.93)	QSSYMEPMhasTSYPSGMPPSQGP.PPP...
  243-  263 (31.50/ 7.33)	QGGYADRM.....QPTGPPV.AGP.SPQ...
  320-  343 (29.49/ 6.38)	..QVHHTM...EHSPYQRH.SPYPhPPA.PM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.89|      20|      25|      77|     100|       4
---------------------------------------------------------------------------
   86-  111 (26.72/10.58)	QQQPSVLENLINSPQfgsQPTPsgrP
  368-  390 (32.17/ 6.51)	SFGPFTKRRKLPAPPtgiGPPP...P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.07|      21|      25|     141|     161|       6
---------------------------------------------------------------------------
  141-  161 (37.52/28.92)	QRMYMEKLRS....LKAYCEPLRAR
  163-  187 (33.56/25.10)	QQCRMEGNESaankFDTMCSVIEGR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02250 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GDTQGGYADRMQPTGPPVAGPSPQWQPAVNTQHSPHAPPSMVSSMGLNPQMQPASTGPPNVPLPHMHSPQLHGGAQGPPIQVHHTMEHSPYQRHSPYPHPPAPMRSSSQHHTQKQQSMQQLPPRMVSSSFGPFTKRRKLPAPPTGIGPPPPTMIEPARGTAMDNGSGVEDLYV
2) MYGRMSKSEQQKVGGGEMAQRDMMQRMWKQPQENPVNAYAPPPTIAQSSYMEPMHASTSYPSGMPPSQGPPPPQQKQPPPPHVSSQQQPSVLENLINSPQFGSQPTPSGRPMGGSLNMVSQALVDMPQPQANINAAQHNEQR
240
1
412
142










Molecular Recognition Features






MoRF SequenceStartStop




1) RDMMQRMWKQ
21
30