<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02248

Description Mediator of RNA polymerase II transcription subunit 8
SequenceMHVVVLQAAKVSILAMNAQVSTAFGHQEDPEKFAQAVAHIESKAVDVKSNIEQLLFMLDLQHKSKRQTSRKRTPPSFLACVNRCMHVVVLQAAKVSILAMNAQVSTAFGHQEDPEKFAQAVAHIESKAVDVKSNIEQLLFMLDLQHKSKRQTSRKRTPPSFLACVNRCMHVVVLQAAKVSILAMNAQVSTAFGHQEDPEKFAQAVAHIESKAVDVKSNIEQLLFMLDLQHKSKRQTSRKRTPPSFLACVNRCMHVVVLQAAKVSILAMNAQVSTAFGHQEDPEKFAQAVAHIESKAVDVKSNIEQLLFMLDLQHKSKRQTSRKRTPPSFLACVNRCMHVVVLQAAKVSILAMNAQVSTAFGHQEDPEKFAQAVAHIESKAVDVKSNIEQLLFMLDLQHKSKRQTSRKRTPPSFLACVNRCMHVVVLQAAKVSILAMNAQVSTAFGHQEDPEKFAQAVAHIESKAVDVKSNIEQLLFMLDLQHKSKRQTSRKRTPPSFLACVNRCMHVVVLQAAKVSILAMNAQVSTAFGHQEDPEKFAQAVAHIESKAVDVKSNIEQLLFMLDLQHKSKRQTSRKRTPPSFLACVNRCMHVVVLQAAKVSILAMNAQVSTAFGHQEDPEKFAQAVAHIESKAVDVKSNIEQLLFMLDLQHKSKRQTSRKRTPPSFLACVNRCMHVVVLQAAKVSILAMNAQVSTAFGHQEDPEKFAQAVAHIESKAVDVKSNIEQLLFMLDLQHKSKRQTSRKRTPPSFLACVNRCMHVVVLQAAKVSILAMNAQVSTAFGHQEDPEKFAQAVAHIESKAVDVKSNIEQLLFMLDLQHKSKRQTSRKRTPPSFLACVNRCMHVVVLQAAKVSILAMNAQVSTAFGHQEDPEKFAQAVAHIESKAVDVKSNIEQLLFMLDLQHKSKRQTSRKRTPPSFLACVNRCMHVVVLQAAKVSILAMNAQVSTAFGHQEDPEKFAQAVAHIESKAVDVKSNIEQLLFMLDLQHKSKRQTSRKRTPPSFLACVNRCMHVVVLQAAKVSILAMNAQVSTAFGHQEDPEKFAQAVAHIESKAVDVKSNIEQLLFMLDLQHKSKRQTSRKRTPPSFLACVNRCMHVVVLQAAKVSILAMNAQVSTAFGHQEDPEKFAQAVAHIESKAVDVKSNIEQLLFMLDLQHKSKRQTSRKRTPPSFLACVNRCMHVVVLQAAKVSILAMNAQVSTAFGHQEDPEKFAQAVAHIESKAVDVKSNIEQLLFMLDLQHKVPWPDMLDKFSSLASAMGQLQTVLRKSALPSGIEDFGKLLRKHLLVPHTLLNQIDPDLQDWQNKLRRLTVRIRPPIDAPDMLDKFSSLASAMGQLQTVLRKSALPSGIEDFGKLLRKHLLVPHTLSNQIDPDLQVCDRERIIVQVGPDMLDKFSSLASAMGQLQTVLRKSALPSGIEDFGKLLRKHLLVPHTLSNQIDPDLQDWQNKLRRLTVRIRPPIDAPDMLDKFSSLASAMGQLQTVLRKSALPSGIEDFGKLLRKHLLVPHTLSNQIDPDLQQATQNRVHCWNHDVAPDYLRTKPNPEVEADEMQLDNEKNSRTFDQVNKQIAAMNKHLESLLNSLADNARSQADAHVDVPIYNNQDTQKLVRAVINGEGLRPTRGGVSAENASQAGSTSASSLPAGTHVPARTAASVMPQQQQQRR
Length1661
PositionHead
OrganismToxocara canis (Canine roundworm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Spirurina> Ascaridomorpha> Ascaridoidea> Toxocaridae> Toxocara.
Aromaticity0.04
Grand average of hydropathy-0.216
Instability index72.68
Isoelectric point9.56
Molecular weight184865.16
Publications









Function






Annotated function


ECO:0000256	

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02248
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            15|    3207.73|      83|      83|       9|      91|       1
---------------------------------------------------------------------------
    1-   84 (218.65/130.65)	MHVVVLQaAKVSILAMNAQVSTAFGHQEDPEKFAQAVAHIESKAVDVKSNIEQLLFMLDLQHKSKRQTSRKRTPPSFLACVNRC
   85-  168 (218.65/130.65)	MHVVVLQaAKVSILAMNAQVSTAFGHQEDPEKFAQAVAHIESKAVDVKSNIEQLLFMLDLQHKSKRQTSRKRTPPSFLACVNRC
  169-  252 (218.65/130.65)	MHVVVLQaAKVSILAMNAQVSTAFGHQEDPEKFAQAVAHIESKAVDVKSNIEQLLFMLDLQHKSKRQTSRKRTPPSFLACVNRC
  253-  336 (218.65/130.65)	MHVVVLQaAKVSILAMNAQVSTAFGHQEDPEKFAQAVAHIESKAVDVKSNIEQLLFMLDLQHKSKRQTSRKRTPPSFLACVNRC
  337-  420 (218.65/130.65)	MHVVVLQaAKVSILAMNAQVSTAFGHQEDPEKFAQAVAHIESKAVDVKSNIEQLLFMLDLQHKSKRQTSRKRTPPSFLACVNRC
  421-  504 (218.65/130.65)	MHVVVLQaAKVSILAMNAQVSTAFGHQEDPEKFAQAVAHIESKAVDVKSNIEQLLFMLDLQHKSKRQTSRKRTPPSFLACVNRC
  505-  588 (218.65/130.65)	MHVVVLQaAKVSILAMNAQVSTAFGHQEDPEKFAQAVAHIESKAVDVKSNIEQLLFMLDLQHKSKRQTSRKRTPPSFLACVNRC
  589-  672 (218.65/130.65)	MHVVVLQaAKVSILAMNAQVSTAFGHQEDPEKFAQAVAHIESKAVDVKSNIEQLLFMLDLQHKSKRQTSRKRTPPSFLACVNRC
  673-  756 (218.65/130.65)	MHVVVLQaAKVSILAMNAQVSTAFGHQEDPEKFAQAVAHIESKAVDVKSNIEQLLFMLDLQHKSKRQTSRKRTPPSFLACVNRC
  757-  840 (218.65/130.65)	MHVVVLQaAKVSILAMNAQVSTAFGHQEDPEKFAQAVAHIESKAVDVKSNIEQLLFMLDLQHKSKRQTSRKRTPPSFLACVNRC
  841-  924 (218.65/130.65)	MHVVVLQaAKVSILAMNAQVSTAFGHQEDPEKFAQAVAHIESKAVDVKSNIEQLLFMLDLQHKSKRQTSRKRTPPSFLACVNRC
  925- 1008 (218.65/130.65)	MHVVVLQaAKVSILAMNAQVSTAFGHQEDPEKFAQAVAHIESKAVDVKSNIEQLLFMLDLQHKSKRQTSRKRTPPSFLACVNRC
 1009- 1092 (218.65/130.65)	MHVVVLQaAKVSILAMNAQVSTAFGHQEDPEKFAQAVAHIESKAVDVKSNIEQLLFMLDLQHKSKRQTSRKRTPPSFLACVNRC
 1093- 1176 (218.65/130.65)	MHVVVLQaAKVSILAMNAQVSTAFGHQEDPEKFAQAVAHIESKAVDVKSNIEQLLFMLDLQHKSKRQTSRKRTPPSFLACVNRC
 1177- 1239 (146.64/85.17)	MHVVVLQaAKVSILAMNAQVSTAFGHQEDPEKFAQAVAHIESKAVDVKSNIEQLLFMLDLQHK.....................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     211.35|      14|      15|    1256|    1269|       2
---------------------------------------------------------------------------
 1256- 1269 (28.56/12.18)	MGQLQTVLRKSAL.P
 1272- 1286 (24.28/ 9.44)	IEDFGKLLRKHLLvP
 1331- 1344 (28.56/12.18)	MGQLQTVLRKSAL.P
 1347- 1361 (24.28/ 9.44)	IEDFGKLLRKHLLvP
 1399- 1412 (28.56/12.18)	MGQLQTVLRKSAL.P
 1415- 1429 (24.28/ 9.44)	IEDFGKLLRKHLLvP
 1474- 1487 (28.56/12.18)	MGQLQTVLRKSAL.P
 1490- 1504 (24.28/ 9.44)	IEDFGKLLRKHLLvP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     166.86|      26|      72|    1244|    1298|       3
---------------------------------------------------------------------------
 1244- 1298 (40.77/22.76)	DMLDKFSSLASAmgqlqtvlrksalpSGiedfgkllrkhllvpHTLLNQIDPDLQ
 1319- 1373 (42.03/23.69)	DMLDKFSSLASAmgqlqtvlrksalpSGiedfgkllrkhllvpHTLSNQIDPDLQ
 1387- 1441 (42.03/23.69)	DMLDKFSSLASAmgqlqtvlrksalpSGiedfgkllrkhllvpHTLSNQIDPDLQ
 1462- 1516 (42.03/23.69)	DMLDKFSSLASAmgqlqtvlrksalpSGiedfgkllrkhllvpHTLSNQIDPDLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.79|      20|     140|    1299|    1318|       4
---------------------------------------------------------------------------
 1299- 1318 (45.39/39.76)	DWQNKLRRLTVRIRPPIDAP
 1442- 1461 (45.39/39.76)	DWQNKLRRLTVRIRPPIDAP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02248 with Med8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) HDVAPDYLRTKPNPEVEADEMQLDNEKNSRTFDQVNKQ
2) LVRAVINGEGLRPTRGGVSAENASQAGSTSASSLPAGTHVPARTAASVMPQQQQQRR
1528
1605
1565
1661










Molecular Recognition Features






MoRF SequenceStartStop




1) THVPARTAASVMPQQQQ
1642
1658