<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02245

Description Mediator of RNA polymerase II transcription subunit 6
SequenceMIPSVGGARGMGMGQPQGGYMGGANVGGASGCAHQQVTSLLHQSFKNPNWPPNFITAENVLDYFCDPSNVFYDVSSCNQHLKMQNLNRPIHECLQSMQGIQFAVVGANHPLYVIVKQRRNSPTNGGYMGGANVGGASGCAHQQVTSLLHQSFKNPNWPPNFITAENVLDYFCDPSNVFYDVSSCNQHLKMQNLNRPIHECLQSMQGIQFAVVGANHPLYVIVKQRRNSPTNVTPLCYYYVVNGTVYQCPDLYTFVQSRLIGAVDPLRRALEQARQFSRYNVAKGYYWEFKEPTGESDKEEKEEEKPLTARSTFFQRTRTEQLLRDLFERFPPPDDVKFELDSSEIASGEVNAGDRSGAPSRMGPEAGATANTPSERQQPQPQTGATAKQNVTGPASVPPPETQSNGAAHETSGPMSFPLNGHHQGTDVKRFKME
Length434
PositionHead
OrganismToxocara canis (Canine roundworm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Spirurina> Ascaridomorpha> Ascaridoidea> Toxocaridae> Toxocara.
Aromaticity0.09
Grand average of hydropathy-0.589
Instability index51.55
Isoelectric point6.67
Molecular weight47882.00
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02245
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     112.88|      18|      18|      74|      91|       1
---------------------------------------------------------------------------
   74-   91 (38.90/21.67)	VSSCNQHLK.MQ....NLNRPIH
   93-  112 (17.54/ 6.46)	...CLQSMQgIQfavvGANHPLY
  181-  198 (38.90/21.67)	VSSCNQHLK.MQ....NLNRPIH
  200-  219 (17.54/ 6.46)	...CLQSMQgIQfavvGANHPLY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     271.71|      69|     105|      18|     122|       2
---------------------------------------------------------------------------
   18-  121 (135.86/79.59)	GGYMGGANVGGASGCAHQQVTSLLHQSFKNPNWPPNFITAENVLDYFCDPSNVFYDvsscnqhlkmqnlnrpiheclqsmqgiqFAVVganhplyVIVKQRRNS
  125-  228 (135.86/81.29)	GGYMGGANVGGASGCAHQQVTSLLHQSFKNPNWPPNFITAENVLDYFCDPSNVFYDvsscnqhlkmqnlnrpiheclqsmqgiqFAVVganhplyVIVKQRRNS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.77|      16|      17|     381|     396|       5
---------------------------------------------------------------------------
  381-  396 (28.52/16.69)	PQTGAT.AKQNVTGPAS
  400-  416 (25.26/14.02)	PETQSNgAAHETSGPMS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02245 with Med6 domain of Kingdom Metazoa
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