<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02243

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMTGGESPFAHTRTQQCSCDGFALTMKSSNVISWHHQTPERRHLKRARLGPPDVYPQDAKQEEDNLGADRLKKGYQVAVTSYEHESVVWNAKVPRLDRLDETMIRGAQIVMQVLNKKLDLNASLDKERKRGTKDGVFQNFSHTIRQADKSKERKEWFTDLARGKSLASLARRPPFFRKKEDALEYLCDFKVPVARALWFLKLVAVGQGITSNVNKQKKSTTDQLASEHASLFTKYIKVMLSQMSDSAKLDTNIVYTERWPHFVCICKHAYEDGMIERQEFLMDMCDIFADRFVQRSDRPHFLTLFRLFLTFFSQYTDQITQNLLLSRRCAFLVARRLALNKKELEDTFGRAVNVAEIFEDMTQCQNQRAIILTLCGMLHAILIDCPGALIWNNFQVAEGRPPPLLHHLCGSPLDVLPCALEALPMPPGHGSDKMHELVQLRVAEVKRRSRAVDNRWSLNQTHKAGFGLPCSRKLTPPSPSPLPSLPLSLSPPQNQRAIILTLCGMLHAILIDCPGALIWNNFQVAEGRPPPLLHHLCGSPLDVLPCALEALPMPPGHGSDKMHELVQLRVAEVKRRSRAVDNRWSLNQTHKAGFALTVRTCLEILGALDAARLDQPRCIEKIYNLIFNGERHLQDILLEYLDTEGPQLGQPHFHEEFASLMHLFMELQRAGVFSHDSYVKGLITTGEMSEQVPIMTLIRNREEHEVRQRNGVCMQPMDEFVSARVDDVKEEKRCAMPLASMPLDPIDEHPLLGAEVSPHERFLIHLPVPQTNEYRSECNQRALLLYGIGEHRDTVKNELKKAAREITKIWTKRIVIEFSFSKPSEIRFKKRANRDQINEALQKFKSQTYYDQVVLCGWCCDNFISMITEFVDGHSAVLPAAEGFDVLLSMMEHCKNISAIMELAEEVLSLLASVEQVLAERRVDCVPSIVSTHLGYVLVAYISHNYYYFLHSENAPEIVSGLYRLIENQLKSPESCLTGWGRSIGIFVLNAKKQLIEAELTHKKMEGNRELLKRLLPPWKFSNALSSAKYNAHLFKEFLDESKRIFSFNDYRRLNALINDEEARYSFVVSALTAARQCGSDYDKLVELANICGHLSAQASISAEWCGALQALCCSSVAGNHGFTDLFLVINVEDSKCHYSIAAFYMLLAARNCFSMNALFHQLLQSALSSLLKSDSSKTDVDAEAGVCLALLVLANMVCQSDEPIVLSSMYTGEREPRKCVSGMADKWALSAGHLHDIGEAIFELLFTICIIADYTKNKLRDRIEDKGEHNFRREYISQISKAVLMAMCEQDWVTQRVYRFCEQTNMDAFNSHRLKKNCLGQQLLRMALRRKCERSTVQELTVCNGNSKKSLIDKLLAVLSIWNIRATYFDLKLMIKEISPEGSSSKHAQQGAIAADALIGEIGKCCRDLFTSSHKSEKKLPDAAIGKAFRLKHITNYWLISPLVRLCPKPGNLPASFPAVTVQAKFLREAASMLDTANDSSKERIQQSAWLLSQEPFLNLVLTCLKGEEQQRDGLVGSLLKQLQDLAAKTKDNPTLPYLRKFSLEREGLLLRLSLVGGMFDSVCHPSSCDAWALLFFQLMLYGVVSRERDRFLFESCFDMLSTLLVWSITDPMNAVPVNSQDPDTKYRFANYSVIVKKLRKELNERTLIPELRCLMQFLPIPKPAFELITCEPYGTVPMSPQKLSKGQIGSSPIKATKQGLQFGEKVKISAYDIMQNFNSEISMKRTWTWAMFQAVKLDRSPVPIQKHIQRLIQHAHYNEFVRPTICGMDRPPNLDIYLSPPTMDVSETPVSVHHVSASTTATTTTSMSTPATAAGQMSVSQAPSGEPMIFPGQVGSMQQLPDMTRAQASASPRGTRGGRRKNAAGPSSRSQGATRKKQQRQAAEQLAPPSSTQQMGPQSMAVPGSAPTSAYGWAPQPGPQAAQVQQFSANTQPGTMNQPEDSKMKIHSMILQKRQAQAASGTSSQNFQGMAPASGGQYSQMMMKMEGTSMAMDQHQSYPTGAPQMSMPQDQGAQFGTQQRNYSTQQPQTNVGGVFDSRMMGHQQQAMQFTQQQYQQQY
Length2059
PositionKinase
OrganismToxocara canis (Canine roundworm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Spirurina> Ascaridomorpha> Ascaridoidea> Toxocaridae> Toxocara.
Aromaticity0.08
Grand average of hydropathy-0.307
Instability index47.77
Isoelectric point8.61
Molecular weight231611.94
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02243
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     465.78|     104|     126|     364|     469|       1
---------------------------------------------------------------------------
  364-  467 (233.18/151.68)	QNQRAIILTLCGMLHAILIDCPGALIWNNFQVAEGRPPPLLHHLCGSPLDVLPCALEALPMPPGHGSDKMHELVQLRVAEVKRRSRAVDNRWSLNQTHKAGFGL
  492-  595 (232.60/151.27)	QNQRAIILTLCGMLHAILIDCPGALIWNNFQVAEGRPPPLLHHLCGSPLDVLPCALEALPMPPGHGSDKMHELVQLRVAEVKRRSRAVDNRWSLNQTHKAGFAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     296.77|      69|      73|    1829|    1901|       2
---------------------------------------------------------------------------
 1829- 1901 (115.90/74.45)	MIFPGQVGSM...QQLPDMTRAQASASPRGTRggrrKNAAGPSSRSQGATRKK.......QQRQAAEQLAPPSS......TQQMGPQSM
 1912- 1971 (86.26/46.85)	Y......GWA...PQ.PGPQAAQVQQFSANTQ.........PGTMNQPEDSKMkihsmilQKRQA..QAASGTS......SQNF..QGM
 1973- 2044 (94.61/52.16)	PASGGQYSQMmmkMEGTSMAMDQHQSYPTGA.....PQMSMP..QDQGAQFGT.......QQRNYSTQ.QPQTNvggvfdSRMMGHQ..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.46|      30|      73|    1047|    1079|       3
---------------------------------------------------------------------------
 1047- 1079 (47.99/42.60)	FNDyrrLNALINDEEARYSFVVSA...LTAARQCGS
 1122- 1154 (49.46/34.03)	FTD...LFLVINVEDSKCHYSIAAfymLLAARNCFS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     149.58|      47|      50|     870|     917|       6
---------------------------------------------------------------------------
  870-  917 (72.03/50.95)	VDGHSAVLPAAEGFdVLLSMMEHCKNISAIMELAEEVLS.LLASVEQVL
  922-  969 (77.55/50.28)	VDCVPSIVSTHLGY.VLVAYISHNYYYFLHSENAPEIVSgLYRLIENQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.52|      11|      73|     621|     631|      11
---------------------------------------------------------------------------
  621-  631 (21.58/16.86)	IYNLIFNGERH
  693-  703 (19.93/14.89)	IMTLIRNREEH
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02243 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) SWHHQTPERRHLKRARLGPPDVYPQDAKQEEDNLGADR
2) VSETPVSVHHVSASTTATTTTSMSTPATAAGQMSVSQAPSGEPMIFPGQVGSMQQLPDMTRAQASASPRGTRGGRRKNAAGPSSRSQGATRKKQQRQAAEQLAPPSSTQQMGPQSMAVPGSAPTSAYGWAPQPGPQAAQVQQFSANTQPGTMNQPEDSKMKIHSMILQKRQAQAASGTSSQNFQGMAPASGGQYSQMMMKMEGTSMAMDQHQSYPTGAPQMSMPQDQGAQFGTQQRNYSTQQPQTNVGGVFDSRMMGHQQQAMQFTQQQ
32
1786
69
2054










Molecular Recognition Features






MoRF SequenceStartStop




NANANA