<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02236

Description Mediator of RNA polymerase II transcription subunit 1.1
SequenceMEEMLVECADNEQGDSLLNGEFDLEKIEEEIRMEKIRQAASKHSWDNFSLNLRKNLMEKRIVLDADDREDVQNALSDLRKHMPADEGGDLAAHLRHLADILQCDFQAHTGCYKLKSADLSIELGVEDAHVSSCTVSWFGERAVEANTLKKLIAENKWGTIHNTLSVMLRLLPPNLQREEKCICMRSLELMEKDLLNASMSSMELIEKDLMNLSSTSLPLVDKINAGMLALCQPRTESSPFTIHLLAEPSVFFNVQSGTFVNVNEQAISDGSFLPCAQLSIVTSPTPQLFSDTPLLSAHGEWRTVESGCRLPAAFCLRFSRPIIFCADSLKKLSSVAAVPLVVEGGLNIYEYLFNEDDAKNDILVSLPGCPTQRYVLDQSMLCFHDDGIVREVTFMHPRDVVVIVDTVRAQLAHNALFESLVRAHNPNASLSNAIEIRLTSASVYNFDLIFNFRRTAFIARVNVPPAKMSVSLECIATGGILPETHCASSILAKSWSLGVMMRGVLRRGGAGGMQTPSEEAVLEMKENSNNNVIADGNDDVKVSQCWLPVANTTQQHAKRCNFEFIVADEGTSGGTRSLLTLFKELDQVDELIPPPAQPPGSLTPSAPPRIGEMLAPRTSRIHSENTMTINALSDLDAICDMAANIDDGESNVSEHSGRSSIVERCSPSAVEAQRLRAQVPPQSPSSGNDRYRGAQMSSIPQLSPLEIARQRLAQQTPLSNAADVFEFDDPPRMAPTSAFATSPQFQFPGGVQGSYQFPAIQPARGSMSGGAPLVKRRGRGRKAGSMGDRTGDHATTLIDPNTGFITTTTSARRPRGTATTRRPRRPRKAAQLAASQTHTHQFAIDRPLLQRSFSDVHYSAQISTAATVSNRSETVSEVDGLEESSDEETDPPPPTRLTAPPPTTTTSTAASVPQVTPTPASSCSPAASTKPTTTGSVNSAASSIASSSGSTEANTPVGTSPSAATTAGHSAGATASYQTSKSRKSSLEAVVGKLHCKSSGSSATPASNPYAASDLYDDESEPVSKPQESPATKREGASTPLASASPGARASPSARATPTSSAEQPISDLKIMIKLKQQPTNRSSTPQYPSTISPPSRLTGQPPSSSRSREEKALLRQRQLKEKARMQEERSRKSTKRERKSDSSGSSKKAKLERPPIPVEQKASRVELPPQVPAFASLKNFKIPKRWRNINLLAVKQQVALDATVHSRASVHMPSTKQRLPAALLAEKVASYEADDEMTRQARFVVSSQCTYGGRTATELVLV
Length1263
PositionMiddle
OrganismToxocara canis (Canine roundworm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Spirurina> Ascaridomorpha> Ascaridoidea> Toxocaridae> Toxocara.
Aromaticity0.05
Grand average of hydropathy-0.405
Instability index53.94
Isoelectric point6.82
Molecular weight136707.59
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02236
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     640.51|     124|     127|     918|    1041|       2
---------------------------------------------------------------------------
  527-  631 (84.90/39.26)	....................NSNNNVIA.......DGNDDVKVSQ...............CWLPVANTT................................QQHAKRcnfefIVADEGTSGGTRSLLTLFkeldqVDELippPAQPPG.SLTPSAPPRIGEMLAPRTSRIHSENT.MTiN...A..........
  639-  718 (106.01/51.10)	.....CDMAA........NIDDGESNVS.....EHSG..RSSIVE...............RCSPSAVEA................................................Q...................RL...RAQ......VPPQSPSSGNDRYRG.AQMSSIPQ.LS.PleiARQRLAQQTPL
  736-  898 (132.09/65.72)	TSAFATSPQFQFPGGVQGSYQFPA..IQ.....PARGSMSGGAPLvkrrgrgrkagsmgdRTGDHATTLidpntgfittttsarrprgtattrrprrprkaAQLAAS.....QTHTHQFAIDR.PLLQRS.....FSDV...HYSAQISTAATVSNRSETVSEVDGLEESSDEET.DP.P...PPTRLT.....
  918- 1041 (194.92/100.94)	TPASSCSPAASTKPTTTGSVNSAASSIA.....SSSGSTEANTPV...............GTSPSAATT................................AGHSAG.....ATASYQTSKSRKSSLEAV.....VGKL...HCKSSGSSATPASNPYAASDLYDDESEPVSKPQ.ES.P...ATKREGASTPL
 1045- 1155 (122.58/60.39)	SPGARASPSARATP..TSSAEQPISDLKimiklKQQPTNRSSTP.................QYPSTISP................................PSRLTG.....QPPS..SSRSREE..KAL.....LRQR...QLKEKARMQEERSRKSTKRERKSDSSGSSKKAKlER.P..............
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.85|      16|      16|      63|      78|       3
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   63-   78 (26.14/16.68)	LDADDREDVQNALSDL
   82-   97 (28.71/19.10)	MPADEGGDLAAHLRHL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02236 with Med1 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AVEAQRLRAQVPPQSPSSGNDRYRGAQMSSIPQLSPLEIARQRLAQQTPLSNAADVFEFDDPPRMAPTSAFATSPQFQFP
2) FSDVHYSAQISTAATVSNRSETVSEVDGLEESSDEETDPPPPTRLTAPPPTTTTSTAASVPQVTPTPASSCSPAASTKPTTTGSVNSAASSIASSSGSTEANTPVGTSPSAATTAGHSAGATASYQTSKSRKSSLEAVVGKLHCKSSGSSATPASNPYAASDLYDDESEPVSKPQESPATKREGASTPLASASPGARASPSARATPTSSAEQPISDLKIMIKLKQQPTNRSSTPQYPSTISPPSRLTGQPPSSSRSREEKALLRQRQLKEKARMQEERSRKSTKRERKSDSSGSSKKAKLERPPIPVEQKASRVELPPQ
3) GVQGSYQFPAIQPARGSMSGGAPLVKRRGRGRKAGSMGDRTGDHATTLIDPNTGFITTTTSARRPRGTATTRRPRRPRKAAQLAASQTHTHQFAIDRPLLQR
4) VDELIPPPAQPPGSLTPSAPPRIGEMLAPRTSRIHSENTM
669
853
750
588
748
1171
851
627










Molecular Recognition Features






MoRF SequenceStartStop




1) EQPISDLKIMIKLKQQ
2) NFKIPKRWR
1063
1180
1078
1188