<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02231

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMVRMHPSQTLTSAPTADFCKQEGDDSPPPAKRSRWLGNTKQLTSSVATIDDRLAFMRICEELDRRGVKYRPLAAEPTVGGLLLQITDFSSAVPTASANFLASMVRCVLRLDTRTRVVWPFEHTIVDVPLVADFYQPRFGHKPLRTKTSVREIQSSGGVSLSSTNTADSVTQNMIDRVIAFSHMHEPVKQFAAAYYAHYHKLCSITAFTYHKLVIAYGAQRDQLMFLSWRVMKNTNPKQYFYLTFGIGPNRAIANAKTLSIEPERATQWNPHMLLKDRLQESFNRRRSLTELMQYLIETVAPLSSLHAFTKIKLQSLRAYSQMLCADSPLPVCLQASLVVVDEITIRLVYGPVALEFLLLSGSRVAVRDCSRTVPTAYRLHTFCSRFVAHDLRIAHEERSPGGLSWMRSPSGPSSLPPHQMGRSPASRVVASPMSHMSLSVPPAESEASPLRYVPSEHCSPHSRSPVLIDHNALQRMTSMGRSPASRVVASPMSHMSLSVPPAESEASPLRYVPSEHCSPHSRSPVLIDHNALQRMTSVNESGICPLEEYLFALSYLSHLGAALEGYRREHRGSGAHPVVQFRHLFVTPESVRVSVAGAAPPNMKHEPFIVNFHVHLDEETMSLKLKLDFEGEEIPPVMDVRIAERYFERCVARLGNELAFVSFINACRLAAPGAFSAMVRIMSAQMEWMEESVWRPSLQLTVWSQEGSNPRARLSLGIVIDQTNVSMLILLCLRPTRHDPSERNADASKHLIQLIYNTQTNSVIRRGAAGEEDANGVSQLLANISDKYARLNERSLWPAVHALAHNFMQSRNVSSQ
Length816
PositionTail
OrganismToxocara canis (Canine roundworm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Spirurina> Ascaridomorpha> Ascaridoidea> Toxocaridae> Toxocara.
Aromaticity0.07
Grand average of hydropathy-0.198
Instability index62.24
Isoelectric point9.07
Molecular weight91183.55
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02231
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     182.82|      20|      22|     423|     442|       1
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  399-  417 (31.32/15.34)	SPGGlSWMRSPSGPSS.L..PP
  423-  442 (42.77/24.03)	SPAS.RVVASPMSHMS.LSVPP
  448-  465 (33.48/16.98)	SPL..RYV..PSEHCSpHSRSP
  482-  501 (42.77/24.03)	SPAS.RVVASPMSHMS.LSVPP
  507-  524 (32.48/16.22)	SPLR.YV...PSEHCSpHSRSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.50|      13|      56|     466|     478|       2
---------------------------------------------------------------------------
  466-  478 (27.25/21.24)	VLIDHNALQRMTS
  525-  537 (27.25/21.24)	VLIDHNALQRMTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.26|      12|      33|     209|     220|       4
---------------------------------------------------------------------------
  209-  220 (21.58/12.56)	YHKLVIAYGAQR
  239-  250 (23.68/14.41)	YFYLTFGIGPNR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.67|      37|     278|      69|     105|       6
---------------------------------------------------------------------------
   69-  105 (64.24/38.51)	YRPLAAE.PTVGGLLLQITDFSSAVPTA......SANFLASMVR
  349-  392 (55.43/32.27)	YGPVALEfLLLSGSRVAVRDCSRTVPTAyrlhtfCSRFVAHDLR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     146.03|      45|      56|     538|     582|       7
---------------------------------------------------------------------------
  538-  582 (77.94/55.13)	VNESGICP..LEEYLFALSYLSHLGAALEG..YRREHRGSGAHPVVQFR
  593-  641 (68.09/47.16)	VSVAGAAPpnMKHEPFIVNFHVHLDEETMSlkLKLDFEGEEIPPVMDVR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.66|      27|     250|      32|      58|      10
---------------------------------------------------------------------------
   32-   58 (47.05/30.05)	RSRWLGNTKQ.LTSSVATIDDRLAFMRI
  284-  311 (40.61/24.99)	RRRSLTELMQyLIETVAPLSSLHAFTKI
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02231 with Med14 domain of Kingdom Metazoa
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