<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02228

Description Mediator of RNA polymerase II transcription subunit 23
SequenceMGNGGETVSAYVANVAAVGNDAKKLQWIVLNHVDGVQMREMFWDLSGDVDVDEITCSEAINVLRSMNEDEKSHCCKAALNVLLNKEDHRYVHLERVLSSIFIAACNEGVLPLSDCCELLILCTDFTLSTPIDARKFEYMQRNLHLIDYKGLRNILKLLVVERMQEMLLTLIDRQLNLLPCLFTITELHRVSSNSRAFLLPRVAKKFNEMFISFRPLTEMVTVIGRPWLYPIAAHISFPVSTSSWRLEVATTRLHQRAHLPYKSELFAPQSSLLYTLLRQPRGKDTLSYVIRQNTNMTPQRMQCDELLHMIILEAMSEMEKTDTRLDDPANQYQWMNITQTVTFSLLHGTASFSRLLKILYESLSETVYRKGRDELMWVILQYVAVYIGKVSTEDMQLIANIYNLLYSDEQCWSGADTDPLLFVRFLVPAAIWIHFYKKLGSQASEVLPKPSESLLRQIQFLQEKTADSDPAIQNVADHNAVLAAVANAYSNDMQNFHKLVLTAVDLFLDGPGDDAGSLWRLPHGIICFPKKTPLPLPLIDSLTFHSRNHLFQMCLLKISTMLNVQQSPKLPSPASIDTLMRLAATTEFEYGVKQVLALMPRALASISASASIGATNQPDRSRDLLYILCDMLSYRLINYPLPVIPKVNVILSCYSALSNNQVQMNVALYSALEQVMLRYWMWNSPQEMIILCNALIGKQGKLTALISSPNSFAEPQHASTMPHERPHANLHVSPEMLRSLLLSMFRALKLTGVEMAPEVLQRCNANFSWPLSVSRTFSTQLTGCSIDDGSDSTPSEELFHCVLQDVRRTHEYLCTQAEEPLMKYFTVERRHTLFCVIYHLIYDSKKLHPVFYSMLSSITAKDIIVMVNKFVDYFIYIFKKNPPSDDQTFTTMVSVLNDMVFMHQLIPFDRLLAALVLHPTDDRATEISLLIIHSMVGSFADVRSRLGLLFHFIPSNKLVNTNSSFFNKMSEYYSQYPELTYREMEAKLRRELQLEMGGIRQMEQPAINPELHMPIYYGNLAERILPIVDILLQRALETVVADQLFSTLLMSFKPCYKYHPQPAAYMYSVLYCLDKTLSHTARARIFVLEICGQLEERDGKYALLTPSFIQDNHQLSLPSQFCQDWRFAELPPAGQALTGACIELLASPHPPAVTARALIDLVFIRPLHQPYATINTVALMLTALPSSFQHVFYEHIVSVLDSEALTQGDPSVCFESLESECFLLTENQLLTNLALGHAYLQHCNTCSLAALPEFVRDQLAPKLVTEAQLIFVLRLVVPILQRFYDAKERSKQIQDLAVDVYKMTVKVNERVGVLKYEDAICDLLYHMKYMYVGDFVKNEAEQAIQRLSPSMRIKLKERWARMQPMREKDEEDRISRRSPPPFTLSMRCIRQCSWYWGNMSWLEAEKVLMSRPLGTYLIRDSASDRYIFTISYRTTNSVHHTRLPQHGGKFCLGGPNSLVRSDSLMAFVDTLQRCGERGVCLLMHQKGDRAATQTMALNRALHRHQLLPPLKYLCRVVIRHSFTPYSLSKLPLPPKMLRYVLDPKYLVPPC
Length1550
PositionTail
OrganismToxocara canis (Canine roundworm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Spirurina> Ascaridomorpha> Ascaridoidea> Toxocaridae> Toxocara.
Aromaticity0.09
Grand average of hydropathy-0.031
Instability index44.98
Isoelectric point6.96
Molecular weight177016.80
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process
intracellular signal transduction	GO:0035556	IEA:InterPro
negative regulation of signal transduction	GO:0009968	IEA:UniProtKB-KW
regulation of growth	GO:0040008	IEA:UniProtKB-KW









Interaction





Binary Interactions











Repeat regions





Repeats

































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02228 with Med23 domain of Kingdom Metazoa
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