<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02217

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMTAELGQQTVELSTLVTRAANDSYASLKELVDKCKSSELSDTDKKISILKFLSKTQQRMIRLNVLSKWCQQVPLIHHCQQLASTVSNHDMCFTQAADSLFFMHEGLQQARAPVYDVPSAIDILLTGSYQRLPKCIEDVGTQYALTEEQQKPALKKLDTLVRSKLLQVSIPKEFSNIMVSDGTAMLRLDGEFKVLITLGYRGHLSLWRILHLELLVGEKDKPVKLEATRRHLLGDDLERRMAAAENPFSVLYSVLHELCVALVMDTVIRQVQVLRQGRWKDAIRFELISEGHGASSSSALNPDGESDSSAMRTPGLKIVYWLDFDKNAGASESGTCPFLKIEPGSDLQIKCLHSSFVIDPLMGKEAEFVLDQSCIDVERLLLRAICCNKYTRLLEIKRELVKNVQVCRTADDVVLQSQMGELDIEYKQKDDKCCSKDSEGHEVLCVRAYGSSFFTLGINIRNGRFLLQSSQNIVVSSALLECEEALNQGSMTAAEVFISLRSKSLLHLFASIGRVLGLEVYEHEFNTVKIPKNVSNGSAMLLMGFPDCGSSYFLLMQLDKDFKPLFKLLETQPNPSVKDNLSGELNQVLRIKEIDIGQMQVHEDEMNLSLVDWGKLRSVLPNAVCPNQTSGHEFFSDIRLENSIQIARGHPSGFSSLVDEVFGLEKGSSTPPFSVKNLSSSVNTSLPSQYGSVPMTLHSLKAGSPSPKWEVGMQMPLVSNVTKASSATNHYSGSLFSSGSVKGPVQSSSVGSIPTGQGRNSAGTKLSASKSEQDLASLKSLHSVDSSSSAAMDEEQLRVFSDNSNDALAGSRSSRLLSPPRPTGSRMSIPNSRPNGPQVESFKAAGSGSCATTPVSQTLESTVSYNTGEDVTSKNDRKSGKRTASDMLTLIPSLQGVESNSGICKKRKISDSAGCQLSLPQGVMSAEIIPRTEGYSYGSLIAEANKGNVPSSIYVAALLHVVRHCSLCIKHARLTSQMDALDISYVEEVGLRSGSSNIWFRLPLARGDSWQHICLRLGRPGCMYWDVKINDQHFRDLWELQKGINNTPWGSGVRIANTSDIDSHIHYDPDGVVLSYQSVEVDSIKKLVADIQRLANARTFALGMRKLLGVRAEEKSEELVTSSDTKTPSTKVALDTADKLTEQMRRAFRIEAVGLMSLWFSFGSGVLARFVVEWESGKEGCTMHVSPDQLWPHTKFLEDFINGGEVSPLLDCIRLTAGPLHALAAATRPARAGPVPGVAAALSSIPKQNGSYISSHGLLLSNSTTNVGLPTSGPGANTVMPTASGLTSQTLSMLAASGRGGPGIVPSSLLPIDVSVVLRGPYWIRIMYRKQFAVDMRCFAGDQVWLQPATPPKEGRLSGGSLPCPQFRPFIMEHVAQELNGLDPSFTGQQAGGMANSNNPNPGSGSQMMAANGNRINLPISAAMPRTGNQVASLNRVGNALAGSSNLALMTSAVSLRRPPGTVVPAHVRGELNTAIIGLGDDGGYGGGWVPLVALKKVLRGILKYLGVLWLFAQLPELLKEILGSILKENEGALLNLDPEQPALRFFVGGYVFAVSVHRVQLLLQVLSVKRFHQQQQQQQQNSNPAPEELSQSEISEICDYFSRRVASEPYDASRVASFITMLTLPVAVLREFLKLIAWKKGLSQAQVGDVVSAQKPRIELCLENHSGLNMDENSESSSAFRSNIHYDRLHNSVDFALTVVLDSAHIPHVNAAGGAAWLPYCVSVRLRYSFGESPNVSFIGMNGSHGGRACWLRVDDWEKCKQRVARTVEVNGNSAADVSQGRLKLIADSVQRNLHMCIQGLRDGSGVTTSSGAA
Length1814
PositionTail
OrganismGlycine soja (Wild soybean)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> NPAAA clade> indigoferoid/millettioid clade> Phaseoleae> Glycine> Glycine subgen. Soja.
Aromaticity0.06
Grand average of hydropathy-0.159
Instability index41.61
Isoelectric point7.52
Molecular weight197449.02
Publications
PubMed=25004933

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02217
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     139.26|      44|      46|     566|     611|       1
---------------------------------------------------------------------------
  566-  611 (66.54/59.93)	KLLETQPNPSVKDNLSG.ELNQVLRIkEIDIGQMQVHEDEMNlSLVD
  614-  658 (72.71/54.86)	KLRSVLPNAVCPNQTSGhEFFSDIRL.ENSIQIARGHPSGFS.SLVD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     130.01|      40|      49|    1011|    1053|       2
---------------------------------------------------------------------------
 1011- 1053 (69.06/60.63)	HIclRLGRPGCM..YWDVKInDQHFRDLWELQKGINNTPWGSGVR
 1063- 1104 (60.96/41.16)	HI..HYDPDGVVlsYQSVEV.DSIKKLVADIQRLANARTFALGMR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     440.14|     157|     354|       5|     194|       3
---------------------------------------------------------------------------
    5-  194 (217.48/214.27)	LGQQTVELSTLVTRA.ANDSYASLKELvdkckSSELSdtdKKISILKFLSKT..QQRMIRLNVLSKwcQQvplIHHCQQLAStvSNHD.MCFtQAADSLFF.....MHEG...LQQARAPVydVPSAI....DILLTGSYQRLPKCIedvgtqyaltEEQQKPALKKLDTLVRSKLLQV........SIPKEfsnimVSDGTAML...............RLDGEFKVL
  369-  564 (222.66/140.88)	LDQSCIDVERLLLRAiCCNKYTRLLEI.....KRELV...KNVQVCRTADDVvlQSQMGELDIEYK..QK...DDKCCSKDS..EGHEvLCV.RAYGSSFFtlginIRNGrflLQSSQNIV..VSSALleceEALNQGSMTAAEVFI..........SLRSKSLLHLFASIGRVLGLEVyehefntvKIPKN.....VSNGSAMLlmgfpdcgssyfllmQLDKDFKPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.75|      22|      51|     846|     867|       5
---------------------------------------------------------------------------
  846-  867 (37.73/30.27)	SGSCATTPVSQTLESTVSYNTG
  900-  921 (39.02/31.65)	SGICKKRKISDSAGCQLSLPQG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     134.65|      41|     350|    1157|    1202|       6
---------------------------------------------------------------------------
 1157- 1202 (68.09/56.70)	LW.FSFGSGVLARFVVEWESGKEGCTMHVSPDQlwPHTKFledFING
 1508- 1549 (66.56/40.72)	LWlFAQLPELLKEILGSILKENEGALLNLDPEQ..PALRF...FVGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      81.97|      19|      20|     690|     708|       7
---------------------------------------------------------------------------
  690-  708 (35.23/20.05)	G.SVPMTLHSLKAGS.PSPKW
  711-  730 (25.85/12.55)	GmQMPLVSNVTKASS.ATNHY
  738-  756 (20.89/ 8.58)	G.SVKGPVQSSSVGSiPTGQ.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     204.02|      65|     183|    1235|    1305|       8
---------------------------------------------------------------------------
 1235- 1305 (98.30/55.72)	PGVAAALSSIPKQNGSYISSHGLLLSNSTTNVGLPtsgPGanTVMPT.ASG.LTSQTLSMLAASGRGGpGIVP
 1424- 1490 (105.73/46.46)	PRTGNQVASLNRVGNALAGSSNLALMTSAVSLRRP...PG..TVVPAhVRGeLNTAIIGLGDDGGYGG.GWVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      29.81|      14|      20|     771|     789|      10
---------------------------------------------------------------------------
  766-  787 (11.20/15.77)	SAsksEQDLASLKslhsvDSSS
  788-  804 (18.61/ 8.92)	SAamdEEQLRVFS.....DNSN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02217 with Med14 domain of Kingdom Viridiplantae
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