<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02205

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDTVDSETNVLLVSNIAGVAYRFYEPSADSKQTFFSNALGIETSLREQGRIVSFDATRRGLWYFHIRRSVGAESQGPAELGATAVVNDQFLMSTKHGSMEPSQWHKSLAPEPPTHRPNQTSSGHAAQLQLTGSQQDHEATAITEQTELRQSNGFTPKVLYESFIGALLLTICSSFCSKSEAVPLNFRTVLLPALKASESATDRWIGEQAQALGTLKCYMISTGSLILSFSVTVCPGLASLEDILSSNSNPIGNNILAAPFGVMTNEEQSPSSHSTGAPLAHTPTIQTLAQRSPSNVNSSLWKQACLAIFQLRGVPGAALRECSWVNLLVSKPKLQDTKPENGRAAHSTISIPWPGSLCFRKKAVELSATNRISDTIVVGHDETHDPLGDARGWLSSANEREERISKRHAERSAAGDKENSAVDTRLGKINAPSPVTMRRPSTTGGNAVYPTPPDAIQNLNGVTPSMDGNLSSPGHPLSVVADVDIDCEPPGEENSVHQNDDEMTEAADGKPLRSDNNLLSEAENMFEDMGGDMFGDNDITEADFSFFDEQPDEMGMDMSFDSIKGSRVPSALPINAEEPVASASINAPPSAESAVFAKPELKHARSSQPEDAPQRGRDHPAKSAKRGSSPFDPDSVFKRLRAAASQRTPRGAYGVGLNRGIKVFEKVDFDSKMPILNKKYEHGGLFDFVPNATDTDKLEPGTLPKTDYLRRHGKTRAKQQADSRRPSIVKSTTDPDTQLLDHQLLNLDGDISDGDDSSSDSDIASNLSVKEPVSPVKSTVKQSILGDDDAASYVTTGRDQDLAEEPDEQLALELPRLSLLDGPDTPLFRYFTDPEPLSLDIALSDEDMIQVAQLVAEQAAAGSLSIFSGHSDSALSTATEEDARIEQLTSTRCALQALRDAASSFLGTISPVGLKTLLEVQDGSLTGQGNRVQPRQVPSKDPNSEPIKPSNLYQIPCPHLEVRRADVRMSLLPTAVTFWENLGLAPSSGSKDIRAVCVCPKWTGMIDNAQVFLGRLKSTYETLKLGTFENMPLSAGLEDGVLLYGVDRISTAPDATMMGHGSALLESMETLSGAMSDLEVVDTNVVVYFMYSTSNPGTIVEACMAFQRFFESYRRTLVAKRESAKNEIVLQLVSADAISSSTSMVITPSSDLVKLCMETYDRCTLFGGNMPAPAIRLEQPLPRIIDFKLSPAPSSSLARENSCIHIAYARSIDGRWVTAAWTDDRGNEQATAAYCLGHKGEPETRTMNDVAHEIWQTTVELISTWKVHYRIIMTKCGPADEGEIDFWVDLARTEMHASVTMIVMTVETNPSLQLVPAPIKMSLQPLSIYTTPVSTPQANIVSPEASAAPATPARDTTGAVATPGGESNGDADVDSVLADVMDQTWGAIVNHRLNNTVGTTSIQPALISGYLIKRTGPKAEDVPSIMEVNLVYTEASARTYEPLLREMLSYFRGLGTLARARGVVDRVTDVRPWHVAAAEKALRALYILM
Length1489
PositionKinase
OrganismBeauveria bassiana D1-5
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Cordycipitaceae> Beauveria.
Aromaticity0.06
Grand average of hydropathy-0.316
Instability index46.58
Isoelectric point5.00
Molecular weight161169.14
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02205
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     108.71|      35|      38|     573|     609|       1
---------------------------------------------------------------------------
  573-  609 (54.67/34.24)	PINA.EEPVASASINAPPSAESAVFAKpeLKHARSSQ.P
  613-  649 (54.03/27.87)	PQRGrDHPAKSAKRGSSPFDPDSVFKR..LRAAASQRtP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.86|      31|      37|     846|     882|       2
---------------------------------------------------------------------------
  850-  880 (50.31/42.94)	QVAQLV....AEQAAAGSLSIFSGH.SDSALSTATE
  884-  919 (40.55/16.78)	RIEQLTstrcALQALRDAASSFLGTiSPVGLKTLLE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.51|      17|     739|     535|     554|       3
---------------------------------------------------------------------------
  519-  535 (31.82/24.15)	LSEAENMFEDMGGDMFG
  539-  555 (31.69/14.64)	ITEADFSFFDEQPDEMG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     121.54|      40|      46|     172|     215|       4
---------------------------------------------------------------------------
  172-  213 (64.33/40.19)	CSSFCSKSeaVPLNFRTVLLPALKASE...SATDRWIGEQ..AQALG
  217-  261 (57.21/26.10)	CYMISTGS..LILSFSVTVCPGLASLEdilSSNSNPIGNNilAAPFG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     123.96|      41|      46|    1111|    1156|       5
---------------------------------------------------------------------------
 1111- 1154 (55.67/36.80)	ESYRR.TLVAKRESAKnEIVLQLVSADAISSSTSmvITPSSDLVK
 1158- 1199 (68.29/30.04)	ETYDRcTLFGGNMPAP.AIRLEQPLPRIIDFKLS..PAPSSSLAR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      80.46|      19|      38|     450|     468|       6
---------------------------------------------------------------------------
  450-  468 (35.87/26.69)	PTPPDAI.QNLNGVTPSMDG
  473-  484 (16.52/ 7.14)	PGHP......L.SVVADVD.
  490-  509 (28.06/18.80)	PGEENSVhQNDDEMTEAADG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.70|      27|      37|     760|     795|       7
---------------------------------------------------------------------------
  760-  791 (38.71/25.65)	DSDIAsnlsvKEPVSPVKSTV.KQSILGDDDAA
  799-  826 (41.00/22.47)	DQDLA.....EEPDEQLALELpRLSLLDGPDTP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02205 with Med13 domain of Kingdom Fungi
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