<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02201

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMGVPQRAQQRALTGSALHAHQRSISSSHIQPHSPVRKDAFADHNQPTDPSDVATASSQATTASRHGATPRRAAGSKLRIELSNDDNVTPGPATDSPQATPSITSHSAAPDSSTDVSGHGSPALSRASHADSAIPRMPMPQRRGPLQRFVASSKTPAPPTAPLKRDSKPKQYSIEVPLDAPRFLSTNKQDAVHRDPFNKGLFSGNADFFPWTGRHHEDEWSTEAIQKGTWDRGSQNETSSARLAVYPSLKQKTGLNALSTIFMGVLNQRRNRGQITAPSTFKPPPRVTLTDTKREVWLKDLANPTISLRRLSRTIPHGIRGRTLLDQCLNKNVPTERAVWLAKCVGANEIRAFKRKGVTGALVLGNELKWIRDWTIFIEQFVDAVVSSVGEPDWKQRVTYSIRLATVLYSEHLLDRDHYLDWIVSGLENSSQAKLPMWILIAQICWTDILRSRKSGRRLVFALLNHLNTIYNDLDRDILMPLSNQLASLLKTLVVNNPESFIQPLQWLKYRESLSAFLPPDESVLQQAYRSINQRNSELLVSSTASPPIGGKEHLVKLLDATLHGKVDRDLSTKCWSISEDKTQVLKTVIEWVTSFHRPGLEKIYTATNLLRSWGSFRINTTGAILDALDSIEPNDIVRKQAVYRLVTELARTGHFSISQYIQWLIARGNCHSAADVEDTGPCASRLLVELPVHCIPEDRKLDRANLLRRAANYDVADEARDIEIAIKCVSQTLRLPGYNIKHDDPALPSKPLPLRKLVSRINSSSFALKSALGTHIRDAFQRLLPPRLDADISLNVFTSTRTILETTRDFSMLGEVIRSCSKISNIEVLAACVDTINVNLQILLAVGIADDLFTLFVERLKAASREHGLVARPLLAALSSLAQRMPNQGEMAKNLQQELTQTDRSNPIDACSPVSDNMVSQSTSPEGEVSEQIDRLLATGNSVDHPTMNRLFRHIVPRLEAGWNKLDASRRVYASLLARLRIFDTPHFDKLMSDWVSHMRSLKERPALLELLPLLVSLGCLTMATVLHTANAAPVAANVNAIESGPPRGSAIYLEELLQLILRKLPQKSPLTADESYRFVVYQQSAKIEHSKALLLLIRNAVQEYSILRCRSSTTAPPLDDRSSQDDVLEALRVLVVTEPTAAAEALSMKDLAPEASALIRAIAAKLLAPGDENTSSSFDKILGLANELTMPFCQLSLSMELSLPQDSRNGNEADSQFDVFARAMDSAIEARNIMWTSMLPCLSDDITQHLRSQAHGRFLDMIPSSKAPNLTELATSEDRIQLAKNLLGVIEAIISGQPPSKSAQLTSMLVDKLTDLWEIISSHETSAARDAVRKHWLPFLLRFITLHSIYSSSSADVSTPTAASASGASSTVVNKNVNNVGAPAATTTATNSVTNTNNEARARIVFVLCGILFALEAQQTLPPDGKLAQQVFDIALLLVDALPDDLRLHCARGVLANPSAVPSGAMASTATSSRGGTSDSRIYYLFSAPRPTAADNLMLAHRDKSAIPLSAAARGLGAMYGIGPTLQERYSHFTFRRWEALSEPTPNVGENDTSLSLGLFEAIKIQ
Length1567
PositionKinase
OrganismBeauveria bassiana D1-5
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Cordycipitaceae> Beauveria.
Aromaticity0.06
Grand average of hydropathy-0.222
Instability index44.91
Isoelectric point8.72
Molecular weight172251.19
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02201
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     627.30|     217|     551|     309|     856|       1
---------------------------------------------------------------------------
  309-  560 (324.48/466.79)	RL...SRtiPHGIRGRTLLD..QCLNKNVP...............TERAVWLAKC..VGANEI.RAFKRKG.....VTGALVLGNELkwirDWTIfIEQFVDAVVSSVgEPDWkQRVTYSIRL.ATVLYSEHLLDRDHY....LDWiVSGLENSSQAK.....LPMWILIAQICWTDILRSRKSGrrlvfALLNHLNTIYNDLDRDILMPLSNQLASLLKTLVVNNPesfiqplqwlkyreslsafLPPDES....VLQQAYRsINQRNSELLV..............SSTASPPIGGKEHLVKLLDA
  859- 1131 (302.82/260.25)	RLkaaSR..EHGLVARPLLAalSSLAQRMPnqgemaknlqqeltqTDRSNPIDACspVSDNMVsQSTSPEGevseqIDRLLATGNSV....DHPT.MNRLFRHIVPRL.EAGW.NKLDASRRVyASLLARLRIFDTPHFdklmSDW.VSHMRSLKERPallelLPLLVSLGCLTMATVLHTANAA.....PVAANVNAIESGPPRGSAIYLEELLQLILRKLPQKSP...................LTADESyrfvVYQQSAK.IEHSKALLLLirnavqeysilrcrSSTTAPPLDDRSSQDDVLEA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.24|      17|      17|     166|     182|       2
---------------------------------------------------------------------------
  166-  182 (30.92/18.99)	SKPKQYSIEV.PLDAPRF
  184-  201 (25.32/14.08)	STNKQDAVHRdPFNKGLF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.73|      29|    1314|      98|     135|       3
---------------------------------------------------------------------------
  102-  133 (45.93/39.96)	ITSHSAAPDSSTDVSghgSPALSRASHADSAI
 1345- 1373 (49.80/19.10)	ITLHSIYSSSSADVS...TPTAASASGASSTV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.70|      21|    1315|     222|     249|       6
---------------------------------------------------------------------------
  224-  244 (38.79/33.63)	IQKGT..WDRGSQNETSSARLAV
 1311- 1333 (32.91/ 9.88)	VDKLTdlWEIISSHETSAARDAV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.77|      18|     124|      21|      38|       8
---------------------------------------------------------------------------
   21-   38 (33.32/17.44)	QRSISSSH..IQPHSPVRKD
  146-  165 (27.45/13.05)	QRFVASSKtpAPPTAPLKRD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02201 with Med12 domain of Kingdom Fungi
Unable to open file!