<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02198

Description Mediator of RNA polymerase II transcription subunit 4
SequenceMDKLIDERFERLEKALSGLIDSVTKYHPSMNLAEELMAADAELTKGLEQGKYDQETRAQRIFFSYLKIIYARLEEISLTVHPAVQTHQNNHLRILELRQASTSLDTQIRDTLTSLSNTRRDIVNTHTTKFPSSPNYPIVYEELLSYARRISKTTMPPAATINASFPPSGLQSPTVGESQSQAVTPAATTPAAGATPAAAATPATSTPLPTQSPAAINGVGGTHGVSLQQSSHHPHQGSSSGPSLLTSLPEPMAQYLNPLSGQVFFPWPQEDKIRSGSLASNQILVEKGIDPRGFDPVAEEERKRKEEADRKEREEREAREQEERDRIMREERERLRQERERQREKEQNEWRRASVIAGAADAPGGAAPKGPEKKQFQFTNLDDLDDDDDDD
Length391
PositionMiddle
OrganismBeauveria bassiana D1-5
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Cordycipitaceae> Beauveria.
Aromaticity0.05
Grand average of hydropathy-0.823
Instability index52.64
Isoelectric point5.33
Molecular weight43516.72
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364141

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02198
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      73.10|      15|      15|     305|     319|       1
---------------------------------------------------------------------------
  305-  319 (25.47/15.68)	KEEADRKEREERE.AR
  321-  336 (22.11/12.63)	QEERDRIMREERErLR
  337-  351 (25.52/15.74)	QERERQREKEQNE.WR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     103.51|      23|      26|     151|     173|       2
---------------------------------------------------------------------------
  116-  137 (36.34/14.30)	SNTRRDIVNTHTTKFPSSP.NYP
  151-  173 (42.09/17.41)	SKTTMPPAATINASFPPSGLQSP
  196-  213 (25.08/ 8.20)	.....PAAAATPATSTPLPTQSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.09|      16|      31|     256|     274|       3
---------------------------------------------------------------------------
  256-  274 (23.57/27.59)	LNPlSGqvFFPWPQEDKIR
  289-  304 (29.52/20.04)	IDP.RG..FDPVAEEERKR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.12|      14|      25|      65|      78|       4
---------------------------------------------------------------------------
   65-   78 (22.65/17.05)	YLKIIYARLEEISL
   91-  104 (22.47/16.86)	HLRILELRQASTSL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02198 with Med4 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MPPAATINASFPPSGLQSPTVGESQSQAVTPAATTPAAGATPAAAATPATSTPLPTQSPAAINGVGGTHGVSLQQSSHHPHQGSSSGPSLLTSLPEPMA
2) YLNPLSGQVFFPWPQEDKIRSGSLASNQILVEKGIDPRGFDPVAEEERKRKEEADRKEREEREAREQEERDRIMREERERLRQERERQREKEQNEWRRASVIAGAADAPGGAAPKGPEKKQFQFTNLDDLDDDDDDD
155
255
253
391










Molecular Recognition Features






MoRF SequenceStartStop




1) EWRRASVIAGAADAP
2) GAAPKGPEKKQFQFTNLDDLDDDDDDD
349
365
363
391