Description | Mediator of RNA polymerase II transcription subunit 19 |
Sequence | MSFHPQTPQSPSQASPATQLDSMPIANPAPTGPTTLPTPAHSVTGSISHQSDTAMADESPHKRKRPLDDDGERDQKKVQYDYKLGIEDLHLDVGPKYMLLQRTYKDEFPLLMRDLYEEFDLAELAAEVAREKPNGEKNALRKTYKGHIKRLGVAGHFDVQKKKEDAPSDFMAMLQVPDLEWSVHQVKGREIGDGFSEATTASLARAMTLSKGPIARSVWDTSVLGDMAPSNNNGEAAKPAAPARATAPNTPAATTPSAATDRLKGPLAPGTDPARPRRNIRKRTYGDSSYEGYGEGFPDDDGGADTGYSTGEGEGGQKRRKKGQQNSGATPPYPPVRQHSYGPGMVGA |
Length | 348 |
Position | Head |
Organism | Beauveria bassiana D1-5 |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Cordycipitaceae> Beauveria. |
Aromaticity | 0.06 |
Grand average of hydropathy | -0.874 |
Instability index | 47.73 |
Isoelectric point | 6.52 |
Molecular weight | 37563.31 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364151 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP02197 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 101.05| 31| 37| 208| 244| 1 --------------------------------------------------------------------------- 208- 244 (49.92/31.66) TLSKGPIAR..SVWDTSVLGDMAPSNNngeaakPAAPAR 246- 278 (51.13/22.79) TAPNTPAATtpSAATDRLKGPLAPGTD......PARPRR --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 94.01| 21| 37| 100| 120| 2 --------------------------------------------------------------------------- 75- 92 (24.58/14.91) .QKKVQYDYKLGIEDLH..LD 100- 120 (37.14/25.97) LQRTYKDEFPLLMRDLYEEFD 140- 158 (32.29/21.69) LRKTYKGHIKRL..GVAGHFD --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 81.95| 25| 28| 5| 30| 4 --------------------------------------------------------------------------- 5- 30 (41.77/28.57) PQTPQSPSQA...SPATQLDSmPIANPAP 33- 60 (40.18/22.47) PTTLPTPAHSvtgSISHQSDT.AMADESP --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) QKRRKKGQQ 2) YPPVRQHSY | 317 333 | 325 341 |
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