<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02190

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMDSQPSAARAALQEAVKYWSDFVARCIVQRLDSNRFLDFVQLVHARHPLPPVLVADLFLRPQPSNRVSLDPRIPPYVRILAQLRYVDAPSILRVLYKYSALHAHDRPPLPLPSSLPENGGDGETMKKEEEEEEKGAAGGGGVMRQDKMVRWQESAWAEEVLFYHVIKTMFEGTAFTDAKTGLELVDITCKWMDLFVHASSELAADMLANKHDRQARDEMETVRAALVPLLLRLVDNHELLRIISKPFAKGGENVLASHGCITVQPPPLYIERLEIFRTQTLAQLDPIDEKKKAANAAMEELLDSTVGSDNFVIPEILISNSRAALYVYLNAALVARPVLDDSMLYAFLSNKYQENQQASAVDLIVASFDVLANAVFRNEGPRDAHLLRSFVVNKLPLLLCQLCHPEFSAASAEFCITEALSRVDTGIFPTASLMFDESRNNNPYMDSVREEFCAACALHGLIERDHVDRILGETSMSYDPSLERANRDRLVSDCLSDSGRIQNIISQLDRVDGNVGAVAHAIVELIRQLCNNKDTTSLKLLCLQLSQKPQSLDIILLFDKVTSVLEPVCTLLDNWNYEEDQGEYQPVYEEYGAILLLVFAFTYRYNLSPLDIGIQSADSHVAKIIAKSHMLRPLEDLNEQEAEHVAGWITGLFDNETGGLGDDLMSSCPPHEFYLLVAPIFQSIITAYTYGYINDESLKGGVEYLVDTFLLPSLVPAIRFFSISGEASTVLSAVKNLIAQPLEHALRTYQRQDPRNQDIEPLLRSLKENLPLSRRTGGPEHHEMVSWANNSNSGLSGAIRHTMQGLVQWSLQPGVNVMPTSYTHRQLITGLRIIGPSRLLRLIMEEIRQQSELGNASIVYDVAAALIAATDPTNEAPPGPNLLDTAGTMQATPPPQRPQGLREALKTAAEGCKRLQKHDQFLAEATVRLHRMLLVVPQPQAMLQTTDMPLDLGGDAMAAAAAAAAAVGADPMSVDGLDTTGLDTTGLDLGLGADMGLSGGGSDGDLFGGLDTSLDMFDGWDSMDMGVN
Length1028
PositionTail
OrganismBeauveria bassiana D1-5
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Cordycipitaceae> Beauveria.
Aromaticity0.07
Grand average of hydropathy-0.110
Instability index44.06
Isoelectric point4.88
Molecular weight113229.66
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02190
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.26|      29|      37|     945|     981|       1
---------------------------------------------------------------------------
  945-  979 (43.42/41.55)	TTDMPLDLGGDaMAAAAAaaaavGADPMSVDGLDT
  984- 1012 (53.83/28.47)	TTGLDLGLGAD.MGLSGG.....GSDGDLFGGLDT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.31|      16|      37|     405|     420|       2
---------------------------------------------------------------------------
  405-  420 (28.25/19.98)	PEFSAASAEFCITEAL
  443-  458 (29.06/20.77)	PYMDSVREEFCAACAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.12|      18|      23|     607|     625|       3
---------------------------------------------------------------------------
  607-  625 (27.92/22.81)	LSPL.DIGIQSADsHVAKII
  631-  649 (30.21/19.46)	LRPLeDLNEQEAE.HVAGWI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.61|      17|      38|     794|     810|       4
---------------------------------------------------------------------------
  794-  810 (31.92/21.06)	GL.....SGAIRHTMQGLVQWS
  830-  851 (22.69/12.89)	GLriigpSRLLRLIMEEIRQQS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.44|      14|      38|     460|     473|       5
---------------------------------------------------------------------------
  460-  473 (24.16/14.73)	GLIERDHVDRILGE
  480-  493 (21.28/12.08)	PSLERANRDRLVSD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     191.97|      62|     284|       1|      66|       6
---------------------------------------------------------------------------
    1-   66 (98.44/94.35)	MDSQPSAARAALQEAV..KYWSD.FVARCIVqrLDSNRFLDFVQLvHARHPLPPVLvADLFLRPQPSNR
  287-  351 (93.53/72.40)	IDEKKKAANAAMEELLdsTVGSDnFVIPEIL..ISNSRAALYVYL.NAALVARPVL.DDSMLYAFLSNK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02190 with Med5 domain of Kingdom Fungi
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