<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02187

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMNSVRPQQPKRRGGLVAPNEHGSAGGGPNAARATKLPPSIRGGFAFPDQAHLQPRNNLTIPHRSQAPLYSRSIAGFLSPTRAAARDDAPASTAMATGDGPPLSMRPFPVADKSPKSLADFISRVNALPGGFRSVTETSLEEELDARRRRDGTTTSGGEEDAAQDDDVDMSDDANAEDEEDDDEDTAAKDPMTARMEVLKNIDIASNTAMLTLDSLSLLLSKHNPTQASLTLSQQLRELVGIGTMGADRLDDANTTPAKTRDCEAVAMGWTLMEISRTRDAAEDAAAFLGAEMAAEGRYWEGVMGVRQAGWSVCRVPGGGGGSGSGSGSDAHAPGLGVRFGFSEAAPEFQRNGLAPIRRGDDGVPWLDMGRLGGTPERLVVTYERGGKVVGRAASQELHDDDDDDEAGSLQARVLGARNTIFAQELWHELTREARSLAAYDVHPDDEKRLVCAVDADARIIVELLPASTSAAQSQPDAHDDAHDDDENLPENTTAEAISLALHILLTYAHRCNELLRIRPLPPHVPRTRGQHVHTLLRPIIARLLYARSARSATQLVGNLVQTLRRAGITDSSFTLCTPQPTVADFAAANTGPNQPSAAVSLVRHMLQPTDFALDVVLLPGGGGGGDDGDDDQGVSFTVRGRTYLVPVTATYYHVLAPAGAAVHALCAPYPDGYPDLAALADYLCVVAARALAAHYLRKRRAATATAAAAAAATAAATATAGGLEEEEDKDKGQQTWVLGALGTRIRHARDIDRPQLEFVVERDTAATEEGRDSSAAALRLTVSTGGQSWTWTSSSDNSAKETLEAVVDKVLIQ
Length813
PositionHead
OrganismBeauveria bassiana D1-5
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Cordycipitaceae> Beauveria.
Aromaticity0.05
Grand average of hydropathy-0.370
Instability index45.42
Isoelectric point5.02
Molecular weight86261.81
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364140

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02187
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.00|      14|      78|     392|     405|       1
---------------------------------------------------------------------------
  392-  405 (28.23/11.65)	AASQ.ELHDD.DDDDE
  471-  486 (20.77/ 7.10)	AQSQpDAHDDaHDDDE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     172.32|      57|     300|     269|     340|       2
---------------------------------------------------------------------------
   11-   44 (37.73/ 7.95)	..........................RRGGLVA...PNEHGSAGGGPNA.ARATKLppSIRGGF
  281-  341 (93.74/59.59)	AEDAAAFLgaEMAAEGRYWEG.VMGVRQAGWSVCRvPGGGGGSGSGSGSdAHAPGL..GVRFGF
  359-  391 (40.86/11.67)	GDDGVPWL..DMGRLGGTPERlVVTYERGGKVVGR.............................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.57|      16|      16|     163|     178|       3
---------------------------------------------------------------------------
  163-  178 (28.74/13.63)	QDDDVDMS..DDANAEDE
  179-  196 (24.83/10.89)	EDDDEDTAakDPMTARME
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.51|      13|      16|     132|     145|       4
---------------------------------------------------------------------------
  132-  145 (18.14/13.85)	RSVTETSLEEElDA
  149-  161 (24.37/14.12)	RDGTTTSGGEE.DA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.06|      18|      61|     701|     722|       5
---------------------------------------------------------------------------
   80-   97 (32.00/ 8.67)	TRAAARDDAPASTAMATG
  705-  722 (29.06/ 6.99)	TAAAAAAATAAATATAGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     116.11|      36|      88|     550|     587|       6
---------------------------------------------------------------------------
  550-  587 (58.43/38.76)	RSATQLV...GNLVQTLRRAGItdSSFTLCTPQPT.VADFAA
  639-  678 (57.68/32.42)	RGRTYLVpvtATYYHVLAPAGA..AVHALCAPYPDgYPDLAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.45|      21|     488|     110|     130|       7
---------------------------------------------------------------------------
  110-  130 (38.63/27.15)	ADKSPK......SL.......ADFISRVNALPGG
  588-  621 (25.82/15.51)	ANTGPNqpsaavSLvrhmlqpTDFALDVVLLPGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.91|      16|      18|     502|     519|       8
---------------------------------------------------------------------------
  502-  519 (25.28/24.06)	HILLTYAHRCNELLriRP
  523-  538 (30.64/21.28)	HVPRTRGQHVHTLL..RP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02187 with Med17 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FRSVTETSLEEELDARRRRDGTTTSGGEEDAAQDDDVDMSDDANAEDEEDDDEDTAAKDPMTARMEVL
2) LYSRSIAGFLSPTRAAARDDAPASTAMATGDGPPLSMRPFPVADKSPK
3) MNSVRPQQPKRRGGLVAPNEHGSAGGGPNAARATKLPPSIRGGFAFPDQAHLQPRNNLTIPHRSQA
131
68
1
198
115
66










Molecular Recognition Features






MoRF SequenceStartStop




1) MNSVRPQQPKRRGGLVAPNEHGSA
2) PNAARATKLPPSIRGGFAFP
3) SRSIAGFL
1
28
70
24
47
77