<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02183

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFPAGALTNFRSIDGFCNIFWRIYSRVAAGPPTSQLNLRENPVLRSSNELRNSIILLRNMRCLVSPLANGSDLWIFSTNPNFDALGPLYSNKGAGNDTIVAGSVTFQNSVSGSNTAAEIKHRLLSDPESSIFNEALQDKSMHISGEFLKFQAYATYSAFFEAFISATSRALSLHFTQQQKVIPLGTRTLYSSLDENGYPSSCTHAPCTRSFTSFLSTLDINMTAKGRLIVSLSTLPQPGIEQLHLDSESDITAYLNNDLWLAPSGILCRLISIDGYQSNHSNIVSPENIGTLPNDIERSIGKLDAMKQEWKRTVIEWLRKLGLNLKDPQTVLWVEVEVNVSDRPLYDTFSRFTGNRRKVSPFIQILWPSNLCFTRSRSNKTAPINPTEFFSSQAESPLQFAERWLNESFPEVQLLDEQKTDNPSEVDEKHFNYPELSPLDVDSSGIPESLARTVNIPDAQLASAVYPTPPGGALTHNLEAGVVVEGLGASTIEALNYPPSQGESIYNEHGGSTTYLHRNPDFFPAGLDAASSELGVGSGLYDTAADEEFFGDIDGTNFDTKGITEADFSFFDEPDFAGLTGNLEMQTETPEILQANECTSDIPHTYMTKAGAGPSHSVQNRLSAVDDSDSRTRNPSISSPNTTTGEGQRSQATELGQVAPTDGSSRRLISPPLSPIQIKEILSSNGFSHSEFGLINSKTHKSYPEQNQYRPVIFQPKLGSSDKKYKLDGRFWFGPGGGHTTFKMGGYPSDIPTIGFPDKEREKNPKLSTTLTSPSPLVSDNALETKVQSPSASSSCSSDNGSITDHGSKASLRPNNPVSLKRKRDYEGEGITSLSPLERRTLAPGTAKVQLNDQQLALLGVLLSEAVDWPLTGYFSRKENVVFPAFSRREDLPQAAQLVVDQVTQSSLCHIRDDLYKLEGTDCDCVLSDSLFDNSDAIGHLSKLDLRTFATIEDGPNTRKDSPSMKSNTSGSICKICPPHVKIHRGNGFLEVLPAAIGFWETFGLEPLQGKKNILPFCIYPPNITEAADTFMERLGLVYSSGNFGTHSRPSQSNGLIPWTLNAASDQDYASLMHALNISCENLGSALSNLSASDENVVIYIINPFVYEAAIVDICSAFIRLFHKYVGDVDRQHTRHLNELVLQIIPLEFIASPDTLIVPPQIDYLRLALEVYSRCPPKDRSSDWMGCAPPLVLADPIPKVVPFRLSSEPVALLEEGKCLHVAYSQSVDQRWVTAAWTDSSGRYQTTLSYCLRERDSPVSRSISEIRTQIWETSKDIMDMSSSYWRLMVVKDEPIGADEVDMWKSLLDQYNRDKSVKVELGILCVNIKPGLSLKLPTPPLQLSALSQQPTQIVPATTTPGSTPRPDPSPDPSGAAGTPPATHTTVNTPMFTDYTHSHQQQQQPTQQMSQASLDSDQDTILIDKSDETWGVTLSHRLNNSYSLTKYQPALASGYLFRRSGTSDTDGLAVMSVNLIYTNSRRPTDHLLRDILRMYRELATLARTRGIIHILRTSHQHDQQ
Length1518
PositionKinase
OrganismParacoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides brasiliensis)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Onygenales incertae sedis> Paracoccidioides.
Aromaticity0.08
Grand average of hydropathy-0.376
Instability index51.57
Isoelectric point5.30
Molecular weight167381.60
Publications
PubMed=22046142

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02183
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     140.02|      45|      51|     480|     528|       1
---------------------------------------------------------------------------
  480-  528 (67.83/52.90)	EAGvVVEGLGASTIEALNYPPSQGESiYNEHGGSTT..YLHRNPDFfpAGL
  534-  580 (72.19/41.31)	ELG.VGSGLYDTAADEEFFGDIDGTN.FDTKGITEAdfSFFDEPDF..AGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     310.30|     102|     525|      76|     352|       2
---------------------------------------------------------------------------
   94-  201 (159.62/282.03)	GAGNDTIV.........AGSVTFQNSVSGSNTAAE..................IKHRLLSDPESSI.FNEALQDKSMHISgEF..LKFQAYATY.......SAFFEAFISATSRALSLhfTQQQKVIPLGTRTLYsslDENGYPS
  612-  750 (150.68/41.70)	GAGPSHSVqnrlsavddSDSRTRNPSISSPNTTTGegqrsqatelgqvaptdgSSRRLISPPLSPIqIKEILSSNGFSHS.EFglINSKTHKSYpeqnqyrPVIFQPKLGSSDKKYKL..DGRFWFGPGGGHTTF...KMGGYPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     337.22|     111|     596|     766|     890|       3
---------------------------------------------------------------------------
  766-  885 (167.94/118.25)	P...KLSTTLTSPSPL..VSDNALETK.VQSPSASSSCSSDNGSITDHGSKASLR.....PNNPVSlkRKRDYEGEGITSLSPLErrtLAPGTAKVQLNDqqlALLGVLLSEAVDWPLTGY..FSRKENvVFP
  894- 1017 (169.27/89.36)	PqaaQLVVDQVTQSSLchIRDDLYKLEgTDCDCVLSDSLFDNSDAIGHLSKLDLRtfatiEDGPNT..RKDSPSMKSNTSGSICK...ICPPHVKIHRGN...GFLEVLPAAIGFWETFGLepLQGKKN.ILP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     138.02|      46|    1054|     284|     333|       6
---------------------------------------------------------------------------
  284-  333 (64.25/67.25)	IVSPENIGTLPNDIERSIgkLDAMKQEwKRTVIEwLR......KLGLNLKDPQTVL
 1289- 1340 (73.77/54.08)	VVKDEPIGADEVDMWKSL..LDQYNRD.KSVKVE.LGilcvniKPGLSLKLPTPPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.41|      14|     258|       4|      17|       7
---------------------------------------------------------------------------
    4-   17 (26.84/19.40)	PAGALTNFRSIDGF
  264-  277 (27.58/20.19)	PSGILCRLISIDGY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.32|      19|      24|     380|     403|       8
---------------------------------------------------------------------------
  363-  384 (30.44/23.28)	FIQILWPSNLCFTRsrsNKTAP
  390-  411 (27.88/17.27)	FFSSQAESPLQFAErwlNESFP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02183 with Med13 domain of Kingdom Fungi
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