<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02179

Description Dihydroxy-acid/6-phosphogluconate dehydratase
SequenceMAPVTLKTVDGKLGPADDLKDVIQHLFEIQSAVHGYLGPETQQELVRKIKNLTVALSTLSTHTQLPPTQENQPDTNTDPSNPSLASIQLPPEIIDYVDSARNPDIYTREFVELVQRGNQDLHGKREAFASFRDVLAREMRSAMPECRGEVDRVVAATGGAVDGPDEFPDLMEHNADSKEPIGGSVPTNHRIAELEQENEILRQKCAQLRGSKTTSAGKVQSEPDHSATSENTPFTALPFSRIAGIGLSRNDSPSTSTRDASHPEVPENDRRNTSLYHGPTSTVYDDTSPSHRQLEPLNLAAGKLDFDGIDPEIGMHLLSMYWSRQLYTAQIIYRPAFMRDMACEGPYFSKLLLNAIFFVVSKHCDRPELRSDPNDITTAGWKFRQRFTQLLRDCFDKSEITTLQALLIMSNALFSRCDERSLSWLYAGNAFNMFIDLGLHVLPAVDSIPAEELEIRKRVLWGAYLIDKIQCLFQGRPPLLNRVNLRASLDFLDDYDDLEPFQDITYKATKPRGVVPSLNVSLLTSLCDLTTIVERVLREIYSESRESNFVHRANISEEIKSQLRTWRQNLPLRLDYLSFPDQAVLLPQSACLLALFNVLIILVHRPLIIGHDGVINSTTAHESVNACTAAANQIVQILHDYSQHFSLSSAPYMLSYATYISATIHARIVAQKGSNSTVFQSLLLCRNILVEHKRLYSAAEKARENLDKLISHLGISTADENLRSGSPRSSGNNLLNEHILMEESMNIAREPGVADRALEFGSSLLSLELSDLDLEAIAQGFQVDVESHSFWNSLALRRRNQELETRLRVTSEADNAQATVKQPGRTLRSSAWFDCRSNPGMTAIYMERYFNYGITKEELMSGKPMIGIAQTGSDLAPCNRHHIELSKRVREGIRTAGGIPFEFPTHPIQETSRRPTATLDRNLAYLGLVEILTGYFLDGVVLLTGCDKTTPACLMAAATMNIPAICMNVGPMLNGYSKGALTGAGTVLWHGRELFATGDIDEHEFMDYIGRGTPSVGHCNTMGTASTMNALAESLGMALPGSAAIPAAYRHRAQCAYETGKRIVEMVEADRKPCDLMTREAFENAIVANAAIGGSTNAPIHINAIAQHAGVDVSMDDWDTLGSTIPLLLNMQPSGEYLGEEYYRAGGLPAIMAELLDQGKLHGDVLTCNGKTLAENVRGKHTWDRRVIKPYDDPLMKDAGFAHLKGNLFDSAIMKTCVISPAFRNRYLSNPDDPEAFEGSVVVFDGPEDYEHRLENTPHIDEKTILVMRGVGPIGYPGAAEVVNMHPPGRLLKEGIDGLFCIGDGRQSGTSGSPSILNASPEAAAGGNLAILKDGDRLRIDLRKRRVDILITDDEIEERRKALGTEGYPIAPSGTPWQEIFRQETDQLSNGMVLRKAVKYQRLAQEGQPLRHNH
Length1414
PositionMiddle
OrganismPenicillium italicum (Blue mold)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.07
Grand average of hydropathy-0.306
Instability index44.19
Isoelectric point5.56
Molecular weight156412.37
Publications
PubMed=25338147

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
DNA binding	GO:0003677	IEA:InterPro
lyase activity	GO:0016829	IEA:UniProtKB-KW
transcription coregulator activity	GO:0003712	IEA:InterPro
zinc ion binding	GO:0008270	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro
transcription, DNA-templated	GO:0006351	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02179
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.03|      29|     212|     284|     318|       1
---------------------------------------------------------------------------
  284-  318 (42.54/42.78)	YDDTSPshrqLEPLNLAAGKldFDGIDPEIGMHLL
  495-  523 (51.49/32.63)	YDDLEP....FQDITYKATK..PRGVVPSLNVSLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     115.68|      35|     212|    1050|    1121|       2
---------------------------------------------------------------------------
   93-  127 (61.52/22.59)	IIDYVDSARNP.DIYTREFVELVQRGNQDLHGKREA
 1063- 1098 (54.17/60.13)	IVEMVEADRKPcDLMTREAFENAIVANAAIGGSTNA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.39|      17|     212|     775|     792|       3
---------------------------------------------------------------------------
  775-  792 (29.00/23.77)	EAIAQGFQVDVeSHSFWN
 1103- 1119 (33.39/22.33)	NAIAQHAGVDV.SMDDWD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.49|      31|     348|     555|     591|       7
---------------------------------------------------------------------------
  555-  591 (46.50/40.75)	ISEEIKSQLRTWRQNLPlrldYLS........FPDQAVLLpqSAC
  908-  946 (47.99/26.55)	IQETSRRPTATLDRNLA....YLGlveiltgyFLDGVVLL..TGC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.66|      23|    1179|     198|     220|       8
---------------------------------------------------------------------------
  198-  220 (39.68/27.37)	NEILRQKCAQL.RGSKTTSAGKVQ
 1378- 1401 (35.98/24.15)	QEIFRQETDQLsNGMVLRKAVKYQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.97|      18|      23|       9|      26|       9
---------------------------------------------------------------------------
    9-   26 (32.10/20.60)	VDGKLGP..ADDLKDVIQHL
   33-   52 (27.87/16.83)	VHGYLGPetQQELVRKIKNL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.65|      28|     966|     252|     279|      12
---------------------------------------------------------------------------
  252-  279 (52.03/30.09)	SPSTSTRDASHPEVPENDRRNTSLYHGP
 1220- 1247 (51.62/29.80)	SPAFRNRYLSNPDDPEAFEGSVVVFDGP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02179 with Med10 domain of Kingdom Fungi
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