<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02175

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFPGGANTNIHLIDGFSNIYWRIYTEEAGIANNPQESPANGYTILKHLSRLKDLEARLRGLNCLASCPRRLGLWVFSPTPEFESLKPLYVRGSEAESNRIVVGTTTLKVSALGSVSSLDLVKGLSSDNQNQHGTQPAGQPRPHQSQPSSRRQDGYSSSAAIYASFISAVAGAIGLHLIRRHAALPLGSRTLFTAVERSGYESPQINNESILSTSCLTTLNIQLTMSGTITVSAQTVSQTGIMRLCSPCENIAEIIDVQPGTDLWLCPNGTIARLVTANVDLPTVPSLGHPTPGNLPAKRTQWKLDVVQWLRNLGLHVDSIDEEPWVEVEVWEPFFARLAGEAWRQSDDSQSALPLKRMLWPARFCFRRASSSNISSGAQTSFLDEPLDFAERWSTMASSLKLDHNPQFTQNTPITQGPQPKDQEMLSPPKAESLESIESLSRIAQYPDLQSTNLVYPTPPDGAAAVGLNNSNPSEAFADDSDFGLPNATQRSSRRNAPGSDVSPVENSGVGVGTGLYDASDSEDLFGEMNERDFGSKGITDADFSFFDDPGFDGMEGDSRVEDADEAHEASHSQSESEAEAMVGAAPSPNQPPGIPTHVEAHEVHASPTQYEAPRSSEEPVALEEPAHSPMDRAGQTISPPLSPVEVKKILFPGPEADDHQQSTDNRGQGHYHPVAFEKKLGDWDQKYGAAGKFWFSSNGSLDTLNHTPDIPTIGIPHRARSSANAPGSSKDPNRTSLSLIQPESSFRSASVSSESSDDSVEIISEHVPTPSAMPSMPSLKRKRAPSESDIMSVASQEKPMPGTEASPANAAENSTFLGNFLANFSDWTLTGYFSAIPPQQHPVLLRREGQLEIAQLLVDQITQSSLKHPLDGEIGLFDLESKSLSLQALEDSTLLGETSKIDFKRYTSFQDEFFANQLQQQPPQHPPPPKETRKSFISKLSAPHIRVRRGKEYLEALPPAVSFWETFGLEPAHGPKNISAYCIHPQSASEAADVFLRRFGLLYQSCSLGVHARGDDSVAFEDGLKPWKSETSSYESMMQVLKRTCEQLGSELSQSPATADNHVVYIINPFTHAAALADICTAFWHLFQQLVAGSERRPTRISGELVLQIVPLEFIMSTESMVVPPQTDYLNLALEVYSRCRPDDVDMSPLLCAPPMLLADALPRAISFRLAPERSSPLQDGRSLHIAYSKSLDQRWISVAWSDMPGSIQRTMSYCLRYRQSGGVRPISEIRNEIWATTKHIMDKFQARWKVQLATTEPIETDEVEAWASLADHHNKLKPGSLELTILAVNTVPDLILEPPVPPISMSMLNILSSSTPVSTPNPSASIASPEQSGNAATPTSAGPAACSAPTPTEVSLETDSEAFLTDICDDSWLAILSHRLNSSPHLTEFRPALSSGYLLRRKGATDGDGVFAITVNLIYSPRPPASHDNVLKDTLSMYRDLGCLARAKGICSVQNNTLPWHVATALRGQELLSYVF
Length1479
PositionKinase
OrganismPenicillium italicum (Blue mold)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.07
Grand average of hydropathy-0.374
Instability index60.47
Isoelectric point5.14
Molecular weight161365.66
Publications
PubMed=25338147

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02175
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     119.21|      27|      29|    1211|    1238|       1
---------------------------------------------------------------------------
 1181- 1206 (36.96/16.43)	QDGR.SLHIAYS.KSLDQRWISVAWSDM.
 1211- 1237 (48.01/24.42)	QRTM.SYCLRYR.QSGGVRPISEIRNEIW
 1241- 1269 (34.24/15.47)	KHIMdKFQARWKvQLATTEPIETDEVEAW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     984.45|     215|     367|     337|     553|       3
---------------------------------------------------------------------------
  333-  523 (301.45/135.31)	............................EPFF.......................A.......................RLAGE..AWRQS.DDSQSALPLKRMLWPARFCFRRA.SSSNISS.GAQTSFLDEPLD.FAERWSTMAS..SLKLDHNPQFTQNTPITQGP..QPKDQ..EMLSPPKAESLESIESL............SR.IAQYPDLQSTNLVYPTPP.DGAAAVGLNNSNPSEAFADdSDFGLPNATQRSSRRNAPGSDVSPVENSGVGVGTGLYD.ASDS
  524-  678 (227.22/100.81)	ED..LFGEMNERDFGSKGITDaDFSFFDDPGF.......................D.......................GMEGD..SRVED.ADEAHEASHSQSESEAEAMVGAA.PSPNQPP.GIPT.........HVEAHEVHAS..PTQYE.APRSSEEPVALEEPahSPMDRagQTISPP....LSPVE.V............KK.I.LF....................................................PGPEADDHQQSTDNRGQGHYH.PVAF
  679-  885 (244.03/105.88)	EK..KLGDWDQK.YGAAG....KFWF......ssngsldtlnhtpdiptigiphrA.......................RSSAN..APGSSkDPNRTSLSL...IQPES.SFRSA.SVSSESS.DDSVEIISEHVP.TP...SAMPSmpSLKRKRAPSESDIMSVASQE..KPMPG..TEASP..ANAAENSTFL............GNfLANFSDWTLTGYFSAIPP.Q.QHPVLLRREGQLEI....AQLLVDQITQSSLKHPLDGE.............IGLFDlESKS
  892- 1105 (211.75/90.89)	EDstLLGETSKIDF..KRYTS.....FQDEFF.......................AnqlqqqppqhppppketrksfisKLSAPhiRVRRG.KEYLEALPPAVSFWET.FGLEPAhGPKNISAyCIHPQSASEAADvFLRRFGLLYQ..SCSLGVHARGDDSVAFEDG............LKPWKSET.SSYESMmqvlkrtceqlgSE.LSQSPATADNHVVYIINPfTHAA...........ALAD.....ICTAFWHLFQQLVAGSERRPTRISG..............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.10|      10|      27|    1141|    1152|       4
---------------------------------------------------------------------------
 1141- 1152 (16.63/15.16)	RCRPDdvDMSPL
 1171- 1180 (18.47/ 9.06)	RLAPE..RSSPL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02175 with Med13 domain of Kingdom Fungi
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