<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02170

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMADSFTLPLRPIPEKRDRPDTLPVEIAQINNQWGSFREVNEDVLRNKIVEEEGKDGLDELDESDQDATDLDSTERLEQLYKRRAEITQFAMQAHMETMFALDFVSLLLSKQAPRQAETSMSAFLKQVAPLGSLNADVVNPPPKPESTTKDVSAVSRGWRIQNFNAAANKLLQAASRLETEVASETRYWNEVLAVKDKGWKVSRLPREKQALGVQYGFIEATPVFRDRGLASLSRAEDGALLLDEGLIPPNARYVRVRVMQDGRLSGSSKPTRSTFNDDGSIEDRILQARDTVYEEELFHELVREARAIASFGVTTRQNLIQIPASDDLEILLDLVDTDEDTSEPEHDISQQGTSLAEGLAHTIRILLAYAHRQNLRRRTLLPPPLTPKIRSVPEHHLIRPALAYIKHMSHVRWLQSLLNDLFGVLKSANLKPPAYTSKVFSAGRRRQDSPAPAVETLVGQFLTPLMSTFHGNILTPRGSFSIAIHTNLSSPPFGTAFDVSFNMPKYQDLESPGKMYHREEVEAAITHLLLLDVVFTVSSNSGSLKSERDKDKEKPNWDAIYPQHGELLIPSKSEKRKKMKIALSRHELSLEIYTVRCIDGTGRGNWEKPSHHSMPHTWKPSPIAGSPKQPSLMDYVFTQVSQS
Length643
PositionHead
OrganismPenicillium italicum (Blue mold)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.07
Grand average of hydropathy-0.490
Instability index51.88
Isoelectric point6.18
Molecular weight72284.99
Publications
PubMed=25338147

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02170
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.49|      13|      34|     354|     368|       1
---------------------------------------------------------------------------
  354-  368 (16.92/18.65)	SLAEglAHTIRILLA
  391-  403 (24.57/17.72)	SVPE..HHLIRPALA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.22|      31|     111|     131|     173|       3
---------------------------------------------------------------------------
  131-  167 (46.51/45.13)	GSLNADVVNPPPkpeSTTKDVSAvsrGWRIQNFNAAA
  423-  453 (55.72/26.21)	GVLKSANLKPPA...YTSKVFSA...GRRRQDSPAPA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.23|      24|      27|     186|     211|       4
---------------------------------------------------------------------------
  186-  211 (38.34/28.47)	RY.WNEVLAV.KDKGwkVSRLPR.EKQAL
  214-  240 (27.89/13.68)	QYgFIEATPVfRDRG..LASLSRaEDGAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.21|      17|      31|      82|     101|       9
---------------------------------------------------------------------------
   82-  101 (24.71/28.07)	RRAEItqfAMQAHMETMFAL
  114-  130 (28.50/20.87)	RQAET...SMSAFLKQVAPL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02170 with Med17 domain of Kingdom Fungi
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