<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02168

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGVVMDNVAIEGSVRRPGLNEARNGAPNAFDNADKSGHLSGTNGSIYANGVSSGISIPNQHPRTLADKAVEIVPTSPFKLSHITQGFFPFGTLVNRSVQECWNELSELITELATIQVPASGGSIPMNGKPAGNPSSENVHKKLRLLDFAHAKRAEFIKLLVLSQWSRQAADVSRLIDIQGFIRTRHQSYDAALQYVGEVKRDLVRAQVANPDLKTAVEVLSKGRVASLPDLGYKPPRPLTARATLKKLLKLNRIISVRLALHDPVPPPLRNYRVHDGRVTFTISGEFELDLSVAEESKTSQFFFVDIRFLFSPSSPIPKGRIFNELDGKINDLLREDGLMGCFQFLHGLVLTNKISILFKQAVDLSRGLWADALRIELLHRTLVVQYWPRRSGPKSWLEIGVKSGHRGGSSSDPKPGISHLGFRWMRDGQQVSSDAIRFNPGDLSMELILRSVIALHTSHLLSTAFTTLKKHVLFSNHTLSLQAQLSPTEPGDCRLDVQLTAARSVRVSIEPMSGSITLCGTPPVLERLDGDRGLYKSSIEEIISRVARLRCITAVDEIDSGTKALGLEPVNQRVLGLDPRKLFPPGVMRTAFFTHRLWNRHWVAAATSCMDGDRWWLVQLRPTEAAKMGPFYSIGDHSMGVPQAHVVSETLVPPQRRLNYTTCAELVHGLTGILAIHANARYLADLPTMHFWPSLKELHLGTDLTVPDLLFNYSSSALPPAFRVTLPFGVKKESQFKEMIRLVFHGIDSQSRSVVMMAHGALKTRIKSLVPLVSNMDPSLIIEDKGAGFALRLLVPAGHSVVACLFELLQRLECVLSILQSLIRKGMEPKSLSLSRIDFAYGPENKFSAFFDIGAEGPSLSDYVDVADAVSKTKPLFQLKLGIKFESSSPHRRIQEPLTVALNQRFTEAGIESTLQLLATTLPLLRSLDQITPQSNQTDLSIVQITARKPTVYLIHYPRLRSRFHLSTVMHQDRLVWMLRDANGMDQSGRGQVVAFIQEKLYQSKGDGWNGLGDGAVASINKVGNLILELHECLNAPHLQLDREVEAKPEQVPNQLHIKGSTSAAPQAMGNTDVITID
Length1080
PositionTail
OrganismPenicillium italicum (Blue mold)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.07
Grand average of hydropathy-0.116
Instability index45.92
Isoelectric point9.24
Molecular weight119337.04
Publications
PubMed=25338147

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02168
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     241.56|      86|     121|     359|     479|       1
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  149-  248 (118.68/69.53)	FAHAKRAEFI.KLLVLSQWSRQAADVSRLiDIqGfIRTRHQ...SYD..AALQYVG........EVKRDLVRAqvaNP.DLktAVEVLSKGRVAslpdlgYKPPRPL.TARATLKK
  371-  472 (122.88/132.20)	WADALRIELLhRTLVVQYWPRRSGPKSWL.EI.G.VKSGHRggsSSDpkPGISHLGfrwmrdgqQVSSDAIRF...NPgDL..SMELILRSVIA......LHTSHLLsTAFTTLKK
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     261.13|      84|     573|     282|     367|       2
---------------------------------------------------------------------------
  282-  367 (139.39/94.55)	FTISGE...FELDLSVAEE.SKTSQFFFVDIRFLFSPSSPipKGRIFNELDGKINDLLREDGLMGCFQFL.HGLVLTNKISILFKQA..VDLS
  853-  943 (121.74/76.19)	FDIGAEgpsLSDYVDVADAvSKTKPLFQLKLGIKFESSSP..HRRIQEPLTVALNQRFTEAGIESTLQLLaTTLPLLRSLDQITPQSnqTDLS
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     304.09|     100|     140|     559|     678|       3
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  559-  678 (156.60/133.50)	EIDSGTKaLGLEPV..NQRVLGLDP..RKLFPPGVMRTAFFthrlwnRHWVAAATSCMDGDRWWLVQ............LRPTeAAKMGPFYSIGDHSMG......VPQAHVVSETLVppqrrlnyttcaELVHGLTGILAI
  699-  820 (147.49/86.17)	ELHLGTD.LTVPDLlfNYSSSALPPafRVTLPFGVKKESQF......KEMIRLVFHGIDSQSRSVVMmahgalktriksLVPL.VSNMDPSLIIEDKGAGfalrllVPAGHSVVACLF............ELLQRLECVLSI
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.06|      24|      77|      45|      68|       4
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   45-   68 (44.63/25.93)	GSIYANGVSSG.ISIPNQHPR.TLAD
  123-  148 (36.43/19.88)	GSIPMNGKPAGnPSSENVHKKlRLLD
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02168 with Med14 domain of Kingdom Fungi
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