<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02166

Description "Mediator complex, subunit Med12"
SequenceMIPHSSAGGQPWGQPLRTFNGGPGRLDNAQMLGQYDQPDRSASLPQPPTRQPAVVDLTAGGPESQDREPPPKRPKLEVPSGSNTSDTGATGEPRNTPGSAISRPAVSWRGRPAWSFQAVVSEIPSNENRGEGAAGSKLSSPPPLPAQPWVNYFGAEPEGSGVVKSRESSPVGAVQTTPYCIEIPSVAPVYKSQKPADFAPWTGNHPEDVLSEQTAKQGYYDRTQVSQNESNTARPALYAQLKNRTGLQTLSSVFAAALEKRQSHNTIHAPSTFKPPPRVTLTDNKREAWLRDLANPSVPLRRLSRTIPHGIRGKILLDQCLGKWIPVARAVWLAKCVGANEIRAFKRKGTSGALAVGLEAKWVREWTTNVQQFVEGVFAAPKSSDWKAKMTYAVGLTARLFSENLLDHDNFLEWFLSSFEAASIGTIPVWLLMLGIYWNSIMRYRRRGRRLAELLLQKVRQATEARLTQLQPLIDRLSGFIKKLVLDHTSSMILPNSWETYKQQVSSALDLGNKAEKALFQSLAERNARVQRPKHSKQTTQRSPHQRIVRLLDSIRTAQDLSSVFGYLDAFDDKAVLVFKLLEWLSTPFRHGLCRVYIGVRLLRKWKLAGVDIDSHILAFLSRGQNNQKLNIDQIYHVVSELVRSQTFSVGRYLQWLMARGVTDVSSSAEERKDLPIDIGLIAQLPVARLPEHVGNLRSTLLARTGLSASEENAAIDSAKDIISQRLPGIFGVHGPASMKLDSLPQNLSWAVKAEVGQWLRRAIAEHNRGAEPANREAFPVGIASVVSALTPAEFYIVRDALESFDDISMLADVLKFASSCSDSTVLASVADTTNCHFDSLCAIGATTDLFRRLIDAYSGIKRFGMPSLDLIFSLIELGLHIPSELNTVSILRQDLSRMENKSIMAASSPVSEHIPDGFGGVDPFFREQLDQLLQSGNVMDEPTLDAIFNTLIKHLESDDGHANLSANDTCRYLAQLRSFHPKHFDGILTRWVCGHLRSPERTVLLRILPPLIGVGCVTIRAFLALAKRLTLSTPTTVPNAAQLPADLLQLLVSGDEDSKCFDLVSYRFQLAQQEFLNKNSEEALKIVCDAASSNDSGSFNGRSELEHSIIMLLRDLLVRHPECAAQNGMQKLIDQYPAALSVVQKALDLLLGVESQSDGNSVLSKVEKLACMTDDFSLPFCQLKLQVLFHADSGSEDRTNIVDAMFKTAVSDCRAHRLHWVDLVALMAPDAVRQIRERAEKAFFSIPLLDEPIGDVPDSPDKLGSLETAKMYLTIIEELASSIPDSGAPSVAPVLVEKMDSLLHKIITMHNSTLAKGMASIDRSKIERALAFWFSALLRIIVLHRSAFAQPPPSLKINPLHEQLRLLTSIFCIALSRLPGDVLRLFPAADYFPHPTPTEGFRPCPGILLQTHALDVAASLIDIFPDDVRHQCARFLKEKCPSFVPYQNDSRFLYLLGPMADQPANPQQVSAPSPAASGSTTVPTPALLSIAGSSSAQQPVAAASGVSTGPPDSNSMANRLRLHHRGRVVGPYPVRPWELLEDAAPFLGVNDTAVNLGFFDARRVRA
Length1567
PositionKinase
OrganismPenicillium italicum (Blue mold)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.07
Grand average of hydropathy-0.174
Instability index48.53
Isoelectric point8.32
Molecular weight172250.80
Publications
PubMed=25338147

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02166
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     135.07|      43|     204|    1234|    1295|       1
---------------------------------------------------------------------------
  143-  189 (72.00/33.22)	PLPAQPwvnyFGAEPEGSGVVKSRESSP..VGAVQTTPYCIE...IPSVAPV
 1248- 1295 (63.08/40.95)	PLLDEP....IGDVPDSPDKLGSLETAKmyLTIIEELASSIPdsgAPSVAPV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     115.02|      37|     203|     897|     981|       6
---------------------------------------------------------------------------
  845-  885 (56.54/13.90)	GATTDLFRRLIDA..YSGiKRFGMPSLDLIF.SLIElglHIPSE
  920-  959 (58.48/105.93)	GGVDPFFREQLDQllQSG.NVMDEPTLDAIFnTLIK...HLESD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.43|      19|      35|    1303|    1322|       7
---------------------------------------------------------------------------
 1303- 1322 (28.28/24.11)	LLhKIITMHNSTLAKGMASI
 1338- 1356 (34.15/23.18)	LL.RIIVLHRSAFAQPPPSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.13|      21|      35|     355|     375|       8
---------------------------------------------------------------------------
  355-  375 (38.38/28.43)	AVGLEAKWVREWTTNVQQFVE
  393-  413 (35.74/25.90)	AVGLTARLFSENLLDHDNFLE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.89|      19|      35|    1141|    1159|       9
---------------------------------------------------------------------------
 1141- 1159 (29.22/20.48)	LSVVQKALDLLLGVESQSD
 1179- 1197 (33.68/24.90)	LPFCQLKLQVLFHADSGSE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     119.76|      28|     204|     448|     484|      10
---------------------------------------------------------------------------
  448-  475 (45.34/24.84)	GRRLAELLLQKVRQ.ATEARLTQLQPLID
  651-  678 (40.65/33.08)	GRYLQWLMARGVTDvSSSAEERKDLP.ID
 1114- 1135 (33.78/18.08)	...LRDLL...VRH.PECAAQNGMQKLID
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.43|      10|     309|     244|     254|      17
---------------------------------------------------------------------------
  244-  254 (15.20/12.48)	RTGlQTLSSVF
  556-  565 (19.23/10.71)	RTA.QDLSSVF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02166 with Med12 domain of Kingdom Fungi
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