<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02165

Description Glutamate/phenylalanine/leucine/valine dehydrogenase
SequenceMKQNLPSEPEFEQAYKELASTLENSTLFEKKPEYRKALQVVSVPERIIQFRVVWEDDKGQVQINRGFRVQFNSALGPYKGGLRFHPTVNLSILKFLGFEQIFKNALTGLNMGGGKGGSDFDPKGKTDNEIRRFCVSFMTELCKHIGADTDVPAGDIGVTGREIGFMFGQYKKIRNQWEGVLTGKGGSWGGSLIRPEATGYGVVYYVEHMIKYASGGKDSFAGKRVAISGSGNVAQYAALKVIELGGSVVSLSDSQGALVLNGEEGSFTVEDINAIAEIKVERKQIAEIATEAAFSSKFKYIPGARPWTNITGRIDVALPSATQNEVSGDEAKALIDAGCKFIAEGSNMGSTQEAIDVFEAHRNANPGAAAIWYAPGKAANAGGVAVSGLEMAQNSARVNWSREEVDSRLQKIMEDCFNNGLATAKEYVTPAEGVLPSLVAGSNIAGFTKVAEAMKEHGDWWTSPGEFETWPEALKVFKSRAKSSGVQCYVVEMKMLPDRAIPEQWRTFLHQCLANRVDIDEFTDLSGLMFTRSPVKENELLDLLLEARASSSVTWDPLLPLYVDGLCKVGRVKSSSALASLLKHSSILDSSGSGECEGEGQGSPSKSKKQKPSTLMTDIKVIQDVMVFISTGSIPKTVIEAADIYSATVDWILAVVAWHNRSMDPSQQTGGLMGSPDAVSLFESLGILLAALSGTNKGLEVLSSDYNQGLKAKLGQALSSYLPLCIDVSLPLRHRLEELQKVFNLYPGQLSKALHGPAIDGVNVNALQFESSVMDGPVVNTRAGLYVYINSMVVGRPLVDDTILINYLTNRYQGHNDVLIEEIITAAFDVLSNGVYHNESGRTMLLFRSFLVNKLPAFFAAISAASMVPISMEMCISHALSRLDPNAFPSFSQMFSMQGSSVLSDARQEFLFACASHKLIRESSIEQLLGENPMQTLPGGGPYVKDDLVSQINNNHERAEQLIGEIESMEGNAGAIVGAVVDKETMTLKNICNSLSRRPQTLDVMLLFRTTKQVLQPLCAILDSWKWDEDQGENQPVYDEFGSILLLVLAFKYRYDLSPSDMGISNNDSFLLKLMDRGACSQKLSDLSEKQNKDLGAWIGALFIAEGISEETMSSCSPHEFYMLVTTLFDQSLGACESGKLDFDTLKGGFEYLLEPFLLPSLVVALTWLGNHIWESETDPTIPIKTLHSLVKPSSISGEAQAIHQTVLNITGCPLEEQLKNVRTRNQSRTDIKPILDALEPYISFRRVGSCRRSELDTWTSHSAGGLISSIRTTLQALVLWSANPGISMAPHAYTHRQVLAGIRMLGATRVLGAIIDEVKQQTEAGSGHIALDIATTMVCAPMTESFAVDQNNYHPVDTSKETLPRCAILTLRDALSLQHENVPKISESDPLRAEVVVRLARRVNMLMAPPSQVSNIDVSNIIQNMDLGVEGQEGRMHLEPSAADVARNTVNEHDPDNINQMLDKAAADAAAAGMDGGIGVGQDIGLGSGAGMDAIDDVLNAADMAVGNPEFLDLDMEGMF
Length1521
PositionTail
OrganismPenicillium italicum (Blue mold)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.07
Grand average of hydropathy-0.110
Instability index38.71
Isoelectric point5.08
Molecular weight165357.21
Publications
PubMed=25338147

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
glutamate dehydrogenase (NADP+) activity	GO:0004354	IEA:UniProtKB-EC
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
cellular amino acid metabolic process	GO:0006520	IEA:InterPro
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02165
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.65|      11|      17|     533|     543|       1
---------------------------------------------------------------------------
  533-  543 (18.63/10.79)	SPVKENELLDL
  551-  561 (21.02/13.16)	SSVTWDPLLPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     142.30|      27|      27|     117|     143|       2
---------------------------------------------------------------------------
   56-   77 (31.20/17.63)	....D.DKGQVQIN.RGFRVQFNSALGP
   81-  103 (36.45/21.93)	GLRFH.PT..VNLSILKF.LGF.EQIFK
  117-  143 (49.89/32.92)	GSDFD.PKGKTDNEIRRFCVSFMTELCK
  146-  166 (24.76/12.36)	GADTDvPAG..DIGVTGREIGFM.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     143.32|      46|     142|     218|     264|       3
---------------------------------------------------------------------------
  218-  264 (71.62/48.35)	DSFAGKRVAISGSGNVaQYAALKVIELGGSVVS.LSDSQGALVLN..GEE
  356-  404 (71.70/44.14)	DVFEAHRNANPGAAAI.WYAPGKAANAGGVAVSgLEMAQNSARVNwsREE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.59|      18|      36|     454|     475|       4
---------------------------------------------------------------------------
  454-  475 (26.87/25.37)	MKEHGDwWTSPgefETWPEALK
  493-  510 (35.72/18.01)	MKMLPD.RAIP...EQWRTFLH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.24|      12|      31|     926|     939|       6
---------------------------------------------------------------------------
  926-  939 (17.66/17.64)	EQLLGEnpMQTLPG
  960-  971 (21.58/12.45)	EQLIGE..IESMEG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.41|      30|      36|     853|     882|       8
---------------------------------------------------------------------------
  853-  882 (52.88/40.47)	NKLPAF...FAAISAASMVPISMEM...CISHALSR
  886-  921 (43.52/31.77)	NAFPSFsqmFSMQGSSVLSDARQEFlfaCASHKLIR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.13|      14|      35|    1414|    1427|       9
---------------------------------------------------------------------------
 1414- 1427 (24.49/15.80)	VSNIDVSNIIQNMD
 1451- 1464 (26.64/17.87)	VNEHDPDNINQMLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     189.09|      60|     612|     584|     647|      12
---------------------------------------------------------------------------
  584-  647 (99.59/82.35)	HSSILDSSGSGE.............CEGEGQGSPSKSKKQKPstlmTDIKVIQDVM.VFIS...TGSIPKTVIEAADIYSA
 1188- 1264 (89.49/63.87)	HSLVKPSSISGEaqaihqtvlnitgCPLEEQLKNVRTRNQSR....TDIKPILDALePYISfrrVGSCRRSELDTWTSHSA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.50|      21|      35|     652|     672|      18
---------------------------------------------------------------------------
  652-  672 (37.97/26.69)	ILAVVAWHNRSMD..PSQQTGGL
  688-  710 (29.53/18.88)	LLAALSGTNKGLEvlSSDYNQGL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02165 with Med5 domain of Kingdom Fungi
Unable to open file!