<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02163

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMPLIMEDGINVDDLFGEPNSLELGLPATSPIKGLAQCLDEMRLLGCCQKIAWSRMGCIASISTDGLRVIVRHLQCRPSDGKWVLGEESSLAPVLEAHNGNQLAHLSWNETGSELAVVDCSGRISIYSISIALNSITGLRQASFDSGDDGNQVVGMMWLNSQRYVHAFHQAAKVNGRWAYSPFRRRPVGPFHPANKGALICVTRVGQIKLIYQNPDSKWAELPAELKNTGYSDRLLTHASMTATQAGILLSTYSACQKMCLYRVHIGWNPSQWEPAQGKPPGQFPIPTFRLIHCKVDMPSNILNINRGPDHSDQSLPFLNSVYSLTRLEIMPGQFDSPAGSTPNPWILAVLSKPLHAIHDYPDQQGPPSVIVRWHLESATQTLHPKFDEVTSKKSNAQAKPKMELRRLEDVYCDKYIVSVDLVEHGTVLAVSHEDSSITCYDTRTMTVLNGLDDSTTVTCLAQAGFHYPLETSGLHIAFSPNACVAVTLDIDGHMQLRVMEHSFGSTEGLYDENNFSAAIAALTLAFSRGCGVDFNTDDILMVALGQLSPEAQITFISEVYRALPINCNFTAEQDKLMSHPYIPRCLSLQAGLGFRGRLKRRNLSSAVPWASLQLRHASVLFAYFFQYNKGGQTESHDPDVLRMVLGNTKWTLDFSHFLLNEIFDMADEFEDVFNDPEAFTQKLKNSFSLPLLILLSSMSRAFLRFICRGLRGVHAGFASANPASLIGDSRIYYTEICQTLESSPVRIDVYEKFLAGVDSAVKHAYQGAGFGDAERPGPEKELLVNARIPPVLTTAVATLLRQTVPALKSEINRMAIYLGDYSWLGFGNDRRTVLYRKQREVDILKKCPLRPPLPLGNDGRVAPLKKRRCARCCEVSGDTNLPRSLLSFKMIAKLGLLRSCLCGGMWVLETDTGDLTVKTGGANGNGNRTSQT
Length932
PositionTail
OrganismPenicillium expansum (Blue mold rot fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.08
Grand average of hydropathy-0.145
Instability index41.60
Isoelectric point6.94
Molecular weight102971.71
Publications
PubMed=25338147

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02163
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     316.19|      90|     265|     297|     387|       1
---------------------------------------------------------------------------
  210-  263 (66.21/45.71)	........................................IYQNPDSKWA......ELPaeLKNTGYS.DRLLTHASMTATQAGILLSTYS.ACQKMCLYRV
  264-  357 (147.13/118.02)	HIgwNPSQWEPAQGKPPGQFPIPTfRLIHCKVDMPSNILNINRGPDHSDQ......SLP..FLNSVYSLTRLEIMPGQFDSPAGSTPNPWIlAVLSKPLHAI
  358-  387 (27.29/12.97)	HD..YPDQQGPPSVIVRWHLESAT.QTLHPKFD.....................................................................
  636-  700 (75.56/53.17)	HD...PDVLRMVLGNTKWTLDFSH.FLLNEIFDMADEFEDVFNDPEAFTQklknsfSLP..LLILLSSMSR...............................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     123.99|      42|     473|      50|     142|       2
---------------------------------------------------------------------------
   50-   96 (61.84/32.72)	IAWSRMGCIA.SISTDG...LRVIvRHlQCRPSDGkwvLGEESSLAPVLEA
  476-  521 (62.15/32.09)	IAFSPNACVAvTLDIDGhmqLRVM.EH.SFGSTEG...LYDENNFSAAIAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.88|      19|      20|     151|     170|       7
---------------------------------------------------------------------------
  151-  170 (33.62/26.32)	QVVGmMWLNS...QRYVHAFHQA
  172-  193 (34.27/21.32)	KVNG.RWAYSpfrRRPVGPFHPA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02163 with Med16 domain of Kingdom Fungi
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