<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02159

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFPGGANTNIHLVDGFSNIYWRIYTEEAGIANNPQESPANGYTILKHLSRLKDLEARLRGLNCLASCPRRLGLWVFSPTPEFESLNPLYVRGNDAESNRIVVGTTTLKVSALGSVSSLDLVKGLSSDNQSQLGTQPAGQPRPNQSQPSSRRQDGYSSSAAIYASFISAVAGSIGLQLIRRHAALPLGSRTLFTAVESSGYESPHINNESILSTSCLTTLNIQLTMSGTITVSAQTVSQTGIMRLCSPCEDIAEIIDVQPGTDLWLCPNGTIARLVTANVNSPTVPSLGYPPPGNLSAKRIQWKLDVVQWLRNFGLHVDTIDEEPWVEVEVWEPFFARLAGEAWRQSDDSQSALPLKRMLWPARFCFRRASSSNISSEAQTSLLDEPLDFAERWSTMASSLKLDHIAYTAQNTPITQDPQSKDHEMMSPPKAEPLESIESLSRIAQYPDLQSTNLVYPTPPDGAAAVGLNNPNPSEAFADDSDFGIPHAMQRSSRRNAPGSDISPVQNSGVGIGTGRYDASDEEDLFGEMNERDFGSKGITDADFSFFDDPDFDGMEGDSRVEDADEAHEASHPQSESEAEAMLDAEPSPNQPPGIPTHVEAHEVHASFIQSEAPRLSEEPVAPEEPVHSPMDRAGQTISPPLSPVEVKKILFPGPEADNHQNSTDNRGQGHYHPVAFPKLLGDWDQKYGAAGKFWFSSGGSLDTLNHTSDIPTIGIPHRARSSANALGSSKEHNTTSLSLIQSENSLRSASVSSDSSDDSIEIISEHVPTPAAMPTMPSLKRKRASSESDIISVTSQEKSLPGTETSPAYAAENSTFLGNFLANFSDWTLTGYFSTFPPQQHPVLFRREGQLEIAQLLVDQITQSSLKHPLDEKIGLFDLESESLSLQALDTTLLGETSKLDFKRYTSLHDEFVANQPQQQPQQQPPPPKDSPKSFILKLSAPHIRVRRGKEYLEALPPAVSFWETFGLEPAHGPKNISAYCIHPQAASKAADVFLNRFGLLYQSCSLGTHARGDDSVAFEDGLKPWKSETSSYESMMQVLKRTCEQLGSELSQSPATTDNHVVYIINPFTHAAALADICSAFWHLFQQLVAGSERRQTRISNELVLQIIPLEFIMSSEAMVVPPQTDYLNLALEVYSRCRPNDVDMSPLLCAPPILLADALPRAISFRLAPERSSPLQDGRSLHIAYSKSLDQRWISVAWSDLPGSIQRTMSYCLRYRQSGGARPISEIRNEIWATTKHIMDKFQARWKVQLATTEPIETDEVEAWASLADHHNKLKPGSLELTILAVNTVPDLILEPPVPPISMAMLNILSSSTPVSTPNPSASVASPEQSGNAATPTSAGPAAYSAPTPTETSLETDSEAVLTDICDDSWLAILSHRLNSSPHLTEFRPALSSGYLLRRKGATDGDGVFSITVNLIYSPRPPASHDNVLKDTLSMYRDLSCLARAKGICSVQNNTLPWHVATALRGQELLSYVF
Length1478
PositionKinase
OrganismPenicillium expansum (Blue mold rot fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.07
Grand average of hydropathy-0.362
Instability index60.24
Isoelectric point5.05
Molecular weight161564.74
Publications
PubMed=25338147

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02159
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     359.32|     127|     166|     162|     325|       1
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  150-  298 (179.29/158.02)	S...................rrqdgysssaaIYASFISAVAGSIGLQLIRRHAALPLgSRTLFTA.VESSGYESPHINNESilSTSCL.TTLNI...QLTMSGTITVS..AQTVSQTGIMRlcSPCEDIAEIIDvQPGTDlwlcPNGTIARLvTANVNSPTVPS..LGYP.PPGNLSA
  300-  466 (180.03/159.69)	RiqwkldvvqwlrnfglhvdtideepwveveVWEPFFARLAGEAWRQSDDSQSALPL.KRMLWPArFCFRRASSSNISSEA..QTSLLdEPLDFaerWSTMASSLKLDhiAYTAQNTPITQ..DPQSKDHEMMS.PPKAE....PLESIESL.SRIAQYPDLQStnLVYPtPPDGAAA
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.96|      28|      32|     567|     597|       2
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  567-  597 (46.13/34.01)	EAHE..ASHPQSesEAEAmLDAEP.SPNQPPGIP
  601-  631 (44.83/22.92)	EAHEvhASFIQS..EAPR.LSEEPvAPEEPVHSP
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     152.70|      49|     372|     869|     944|       3
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   95-  148 (72.76/27.66)	DAESNRIvvGTTTLKVSALGSVSSLDLvKGLSS..D....NQSQlgTQPAGQPRPNQSQP
  880-  934 (79.94/80.60)	DLESESL..SLQALDTTLLGETSKLDF.KRYTSlhDefvaNQPQ..QQPQQQPPPPKDSP
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     144.94|      40|     167|     484|     542|       4
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  499-  539 (67.94/51.42)	PGSDISPVQNSGVGIGTGRYDASDEEDLFGEMNERdFGSKG
  654-  693 (77.00/31.30)	PGPEADNHQNSTDNRGQGHYHPVAFPKLLGDWDQK.YGAAG
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.41|      15|     228|     482|     498|       6
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  482-  498 (22.82/18.34)	SD...FGIPHaMQRSSrRNA
  710-  727 (24.59/10.92)	SDiptIGIPH.RARSS.ANA
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     268.73|      82|     433|     942|    1032|       7
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  942- 1032 (128.33/87.24)	SAPHIrvrrgKEYLEALPPAVsFWETFGLEPAHGPKNISAYCIH.PQAASKAADVFLNRFGlLYQSCSLGTHARGDDSVafEDGLKPWKSET
 1384- 1466 (140.40/73.52)	SSPHL.....TEFRPALSSGY.LLRRKGATDGDGVFSITVNLIYsPRPPASHDNVLKDTLS.MYRDLSCLARAKGICSV..QNNTLPWHVAT
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.50|      21|    1269|      66|      86|      11
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   66-   86 (41.55/26.00)	ASCPRRLGLWVFS.PTPEFESL
 1337- 1358 (33.96/19.58)	AATPTSAGPAAYSaPTPTETSL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02159 with Med13 domain of Kingdom Fungi
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