<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02158

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMADSFTLPLRPIPEKRDRPDTLPVEIAQINNQWGSFREVNEDVLRNKIVEEEEKDGLDEVDESDQDATDLDSTERLEQLYKRRAEITQFAMQAHMETMFALDFVSLLLSKQAPRQAETSMSAFLKQVAPLGSLNAEVVNPPPKPESTTKDISAVSRGWRIQNFNAAANKLLQAASRLETEVASETRYWNEVLAVKDKGWKVSRLPREKQALGVQYGFLEATPVFRDRGLASLSRAEDGALLLDEGLIPSKPRFVRVRVIQDGRLSGSSKPTRSTFNGDGSIEDRILQARDTVYEEELFHELVREARAIASFGVTTRQNLIQIPASDDLEILLDLVDTDEDTSEPEHHVSQQGTSLAEGLAHTIRILLAYAHRQNLRRRTLLPPPLTPKMRSVPEHHLIRPALAYIKHMSNVRWLQSLLNDLFGVLQSANLKPPAYTARVFSTGRRKQTSTAPAVETLVGEFLTPLLSTFNGKILTPLGSFSIAIHTNLSSPPFGTTFDVSFNMPKYQDLESPGKLYQREEVEAAITHLLLLDVVFTVSSNSGSSKSESDKDNAKHTWEAIYPQHGELLIPSKSEKRKKMKIALSRHELSLEIYTVRCIDGTGRGNWEKPSHHSMPHTWTSSPIAGSPQEPSLMDYVSKQVSQS
Length643
PositionHead
OrganismPenicillium expansum (Blue mold rot fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.07
Grand average of hydropathy-0.463
Instability index50.01
Isoelectric point6.00
Molecular weight72054.58
Publications
PubMed=25338147

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02158
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     111.40|      37|     179|     241|     278|       1
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  241-  277 (67.35/46.58)	LLDE..GLIPS...KPRFVRVRVIQDGRL.SGSSKPT............RSTFNG
  417-  471 (44.05/23.41)	LLNDlfGVLQSanlKPPAYTARVFSTGRRkQTSTAPAvetlvgefltplLSTFNG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.30|      17|      46|     331|     347|       2
---------------------------------------------------------------------------
  331-  347 (31.14/15.59)	LLDLVDTDEDTSEPEHH
  380-  396 (34.17/17.69)	LLPPPLTPKMRSVPEHH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     147.50|      46|      57|     504|     550|       3
---------------------------------------------------------------------------
  504-  550 (71.41/68.63)	PKYQDLESPGKLYQREEVEAAIT.HLLLLDvVFTVSSNSGSSKSESDK
  562-  608 (76.09/67.40)	PQHGELLIPSKSEKRKKMKIALSrHELSLE.IYTVRCIDGTGRGNWEK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.71|      24|      27|     186|     211|       4
---------------------------------------------------------------------------
  186-  211 (38.19/27.50)	RY.WNEVLAV.KDKGwkVSRLPR.EKQAL
  214-  240 (27.53/12.93)	QYgFLEATPVfRDRG..LASLSRaEDGAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     117.51|      38|     345|     117|     164|       5
---------------------------------------------------------------------------
  117-  164 (61.01/55.22)	ETSMSAFL.........KQVAPLGSLNAEV.VNPPPKPESTTKDISavsrgwriqnFN
  455-  502 (56.50/32.57)	ETLVGEFLtpllstfngKILTPLGSFSIAIhTNLSSPPFGTTFDVS..........FN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.17|      14|      33|     363|     376|       6
---------------------------------------------------------------------------
  363-  376 (25.68/19.93)	IRILLAY.AHRQNLR
  398-  412 (22.48/16.50)	IRPALAYiKHMSNVR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02158 with Med17 domain of Kingdom Fungi
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