<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02153

Description "Mediator complex, subunit Med15, fungi"
SequenceMNPGEFPNPGAGPGRPAPNTAMRMNANMQVPKNDSVQSMMTYVAQMLQNQGPYGGWKAEVLIKTRATNVYQMITSLRLIQPRIDLHQAAQAAMSFELKAFTKANEKIEYEKECTEKLLHIRNTRERQAAVAYQSGMMPQTGAGQNQIPGAFPQHINQSMQGSPVSGQQQMAMGMNGQNQQAAIQQQRQQQQSQAMLQQQQQQQQQQQQQQQQQQQRSQQRPGNGIPMVDDLSTLSAQDLDHVSRLANEMLNKTNPEDMEKIKLNLSNMTPEQRQYLARKNLEPMTYFFRSQALNQIRRHRRARLEMGGRAPNAGVDANGNMMGDPMMNSQHQRQMLQSMLNLQRNSAFPGNPGQTMEPPNFIGNVENIQGQQADGLRSQEAGQLVVPASSSQMNQAPFPNNNNNMFPQQMGQNGQANMNANNTNAQAQFLAQQHLQGGSNTPQDRMQFQAQQSQAQAQAQARAQAAQKAQMAMSGHGGQVAPQSQPQLNGQSPVMPMLNQPMAPGQMSPVQVPAQARPPSRPANMGQHPAGVAGKAGMQGPLQIPSNIPPHIQEQLARMPPEQARVFIMQQRRAALNNMARANPGQQPQPQPGQAQSMMNNQMGNAMMRGPMSAPQDLNSGGIPQGQQMTQQQRQQRQNEGYKLQLLRQQNNGVEMTPEQGKQMDRVSFPPSILNMNGTSMQVPNNIKSWGQLKQWASSNPQVASPNDLPRLMMLQKLHLGQLIAASTNQVNQNGQGPAATPFQSTQAPFTNTSGFPSGQQPSAINMASMRPISAQDIQLARQKLGHQASNFTDEQIREILYRNRQKQMMQAAQNRAMQLEGNTQPGQLSQPAAQPPAPAAQPILQMKQQHPQAPQSTPQAANAKPQTGAAAKGAKGATGKQASKKRPSTDDITEARPAATPQMSQPVAVPGAPGTAPQRPGLPFTPEQLAQMTPQQRAQVEAHMRRQQSQSRGQVLSRAAADEAWNRNLPPQVMEVYNDIAKNAPPAKPMPVSPEQKAAMTKQLREALDVLGRLDALVQWFAKMQGQEKNVKNLLAMRIQLMRQFKPSQDWVVNEHFTVTSDYLTGAILFMRKLFAVMISRMQQGQRPNAPQPASSNAQTMQGNMPALNATNLQQLQAQEEALQRARRASSQSVANAPAAPFAAPSPRGVPQYAPGGLAPENLKLPPPKKRKQSHGVASSPIQATAAPGAAAKYNKAVADATSNAAAMAGAFKCSVIECQHHYQGFPTQAALDKHVEESHQPEEEEIIEDYLKYYHESISMGLGLNPNDSPETQQTATLGPSTKLSATASPAKQSIATPLIANNAPMVRVTSQFGAKTASPAAASTQLLTPQLSSVKGMKPADKDVKKEVIKLEDSDTKDPWAECPTSLDTIHDTFSNLASKDLPHLGYDSLEDFDINEATPVDDDWAAFASLTPPDEAEEAAFLEKFYEPWDEESITRTAEWLRIPPEIQVKGIGPMGQLEVDWDAVARYDREGIRISMPK
Length1483
PositionTail
OrganismPenicillium expansum (Blue mold rot fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.04
Grand average of hydropathy-0.765
Instability index59.64
Isoelectric point9.43
Molecular weight162414.37
Publications
PubMed=25338147

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02153
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|    1565.79|     375|     396|     146|     539|       1
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    1-  137 (68.54/ 9.58)	...........................................................................................................................................................................................................................................................................................MNP..............GEFPNPGAG..PGRPAPNTAM.RM.NANmqvpkNDSVQsmmtyvAQMLQNQGP.YGGWKAEvliKTRAT...NVYQMITSLRLIQPRIDLHQAAQAAMS................FELKAFTKANE................KIEYEKECTEKllhI......RNTRERQAAVAYQSGMM
  146-  539 (638.75/195.69)	QIPGAFPQHINQ..SMQGSPVSGQQQMAMGMNGQNQQAAIQQQRqqqqsQAMLQQQQQQQQQQQQQQQQQQQRSQqrPGNGIPMVDDLSTlSAQDLDHVSRLANEMLN..KTNPEDMEKIKLNLS.......NM..TPEQRQYLARKNLEpmtyfFRSQALNQirrhRRARLEMGGRAPNAGVDANGNMMGDPmMNSQHQRQM.LQSMLNLQRNSAFPGN....PGQTMEPPNFI...GNVE.....NIQGQQADGL......RSQEAGQ...LVVPASS.SQMNQ..............APFPNNNNNmFPQQMGQNGQA.NM.NAN.....NTNAQ......AQFLAQQHL.QGGSNTP...QDRMQ...FQAQQSQAQAQAQARAQAAQKAQMAMSGHGGQVA.PQSQPQLNGQSPVMPMLNQ.PMAPGQ.....MSPVQVPAQARPPSR...P......ANMGQHPAGVAGKAGMQ
  543-  882 (422.07/112.69)	QIPSNIPPHI.............QEQLAR.MPPEQARVFIMQQR.....RAALNNMARANPGQQPQPQ.........PGQAQSMMNN.............QMGNAMMRgpMSAPQD.....LN.SggipqgqQM..TQQQRQ..QRQNEG.....YKLQLLRQ...............QNNGVE.....M.TP....EQGKQM........DRVS.FPPSilnmNGTSMQVPNNIkswGQLKqwassNPQVASPNDLprlmmlQKLHLGQ...L.IAAST.NQVNQngqgpaatpfqstqAPFTNTSG..FPS..GQQPSAiNMaSMR.....PISAQ......DIQLARQKLgHQASNFT...DEQIReilYRNRQKQMMQAAQNRAM.....QLEGNTQPGQLSqPAAQPPAPAAQPILQMKQQhPQAP.Q.....STP.QA.ANAKPQT..............GAAAKGAKGATGKQ
  896- 1211 (436.43/116.80)	ARPAATPQ.MSQpvAVPGAPGTAPQR..PGLPFTPEQLA..........Q..MTPQQRAQVEAHMRRQQSQSRGQ.........V..LSR.AAADEAWNRNLPPQVME..VYN..DIAKNAPPAK.......PMpvSPEQKAAMTKQ....................LREALDVLGRL.DALVQWFAKMQGQE.KNVKNLLAMrIQLMRQFKPSQDWVVN....EHFTVTSDYLT...GAIL.....FMRKLFAVMI......SRMQQGQrpnAPQPASSnAQTMQ..............GNMPALN.................................................ATNLQ...QLQAQ...EEALQRARRASSQSVANAPAAPFAAPSPRG...V.PQYAP..GGLAPENLKLPP.PKKRKQshgvaSSPIQ..ATAAPGAA...AkynkavADATSNAAAMAG.....
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.95|      19|      30|    1416|    1445|       3
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 1416- 1434 (36.17/31.87)	PPD.EAEEAAFLEKFYEPWD
 1448- 1467 (30.79/ 8.83)	PPEiQVKGIGPMGQLEVDWD
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.00|      23|      37|    1266|    1288|       4
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 1266- 1288 (39.37/21.71)	LNPNDSPETQQTATLGPSTKLSA
 1301- 1323 (38.63/21.15)	LIANNAPMVRVTSQFGAKTASPA
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.56|      13|      37|    1354|    1371|       5
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 1354- 1371 (17.09/27.80)	LEDSDTKDpwaecPTSLD
 1393- 1405 (23.47/15.23)	LEDFDINE.....ATPVD
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02153 with Med15 domain of Kingdom Fungi
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