<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02138

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMSTDKMPLLLDSGIGGGLPIVDDLFGDVNTLGLPSGGSGKQLQQRIQALKTRGCQQTIAWSKSGAIASITPDGEQLELRFLRAHPETGVWGLSEPTTCGVVKGTPTIPLVHLEWGLAVISELAVFDAVGRVTIVSFPTTLNHGVATRKWDNDPIEDLNAVVGCHWLSVAPGNQQKPYNVLYGPGKQQGNTFQYENTFVPSGGPHHPHAGKSALFSVTMGGTLKMFWTQNNSRIEESSLELESVSSSDGLLTHAAMASDKKYLNVAMLTASKKLRFAKLEIQWAGPGAVQEKSQLTAASRLNPSLVESHLASVDIKEAFIGIDGIATDLTQLHTLPSVIDQSGTNTSPPLILAIRAESGGAGFTIAQTIIDRWEAIEERQSLNSTFEQLGTRRNSISGDFQLPTVTRLKKLEPVIIDKVVVALHSIRFGKVLVLAMADGSVEYRDRTSFEQIYTTMDTDTVTDLRQVGWTFTDEGSCHQVAFSPTCSSKIQLGEDLRLRWSKLHYPLDGMGDSMQDNAYSHSIAAATIATASAVWYMANFDDLVAVMHPLAEKQKFIQDWVGELIRILKIQVDYVEELHHDSLMRNSQLQSCLSIMNNLGFKGEFAPRSFQSKFASVKLNIRNVVILISLANNTPVSMKEKMNPLDEPEVVLALAGCAKWSLDLLSWITESLFELMTNKNFTDLLTPQRFQEVTPFLYERNEISLHLVLSSCSRSFLTAICRRIAHLEDISSRAINFWRQSAQKEPGAAQRPQSVQLQQAYQKMQKVTSSGLIKVGEFEKLLTVLGADIRGMYHTMLPNVVKNSPNPPQGKAMEFAMKAAQIQLELHMLLAKAPAPTFVGVVRKFFAKELPAFRAQTDPASLFFYNFSLLSEEDDPKSLATRKERHVWVDLFNKTELRLGTNQVLWRRCVRCSAVMEDAAAERPGYRFVLSLQRKCSCGGTWALLAHDKLIP
Length951
PositionTail
OrganismTorrubiella hemipterigena
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Clavicipitaceae> Torrubiella.
Aromaticity0.08
Grand average of hydropathy-0.127
Instability index39.58
Isoelectric point6.78
Molecular weight105159.34
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02138
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     478.62|     155|     167|     587|     751|       1
---------------------------------------------------------------------------
  587-  751 (243.75/191.67)	QLQSCLSIMNNLGFKGEFAPRSFQSKFASVKLNIRNV..VILISLANNTPvsmkekmNPLDEPEVVLALAGcAKWSLD...LLSWITESLFELMTNKNFTDLLTPQRFQEVTPFLYERNeISLhLVLSSCSRSFLTAICRRI.AHLEDISSRAIN....FWRQ....SAQKEPGAAQRP
  755-  923 (234.86/157.42)	QLQQAYQKMQKVTSSGLIKVGEFEKLLTVLGADIRGMyhTMLPNVVKNSP.......NPPQGKAMEFAMKA.AQIQLElhmLLAKAPAPTFVGVVRKFFAKELPAFRAQTDPASLFFYN.FSL.LSEEDDPKSLATRKERHVwVDLFNKTELRLGtnqvLWRRcvrcSAVMEDAAAERP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     226.34|      53|     168|      25|      77|       3
---------------------------------------------------------------------------
   25-   75 (81.13/62.90)	................FGDVNTLGLPS....GGSGKQLQ.QRIQAL..KT.RGCQQTIAWSKSGAIASITPDGEQ
  129-  174 (45.84/31.56)	.................GRVTIVSFPTtlnhGVATRKWDnDPIEDL..NAvVGCH....W......LSVAPGNQQ
  177-  239 (65.14/48.70)	YN..vlygpgkqqgntFQYENTF.VPS....GGPHHPHA.GK.SALfsVT.MGGTLKMFWTQNN..SRIEESSLE
  240-  288 (34.23/21.25)	LEsvsssdgllthaamASDKKYLNVAM....LTASKKL...RFAKL..........EIQWAGPGAV.........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     137.62|      43|     169|     330|     372|       4
---------------------------------------------------------------------------
  330-  372 (74.66/44.33)	QLH.TLPSVIDQSGTNTSPPLILAIRAESGGAGFTIA...............QTIIDRW
  501-  559 (62.96/36.36)	KLHyPLDGMGDSMQDNAYSHSIAAATIATASAVWYMAnfddlvavmhplaekQKFIQDW
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02138 with Med16 domain of Kingdom Fungi
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